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Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens

Structure (London), 2016-06, Vol.24 (6), p.965-976

2016

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Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism

Nature communications, 2019-09, Vol.10 (1), p.1-12, Article 4175

2019

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The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria

The Journal of biological chemistry, 2017-11, Vol.292 (44), p.17981-17990

2017

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Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG

Nature communications, 2017-08, Vol.8 (1), p.1-11, Article 222

2017

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Binding and transport of LPS occurs through the coordinated combination of an array of sites across the entire Escherichia coli LPS transport protein LptA

Protein science, 2023-08, Vol.32 (8), p.e4724-n/a

2023

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Linking dual mode of action of host defense antimicrobial peptide thanatin: Structures, lipopolysaccharide and LptAm binding of designed analogs

Biochimica et biophysica acta. Biomembranes, 2022-03, Vol.1864 (3), p.183839-183839, Article 183839

2022

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Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Nature communications, 2022-04, Vol.13 (1), p.1826-10, Article 1826

2022

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LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry

Nature communications, 2023-10, Vol.14 (1), p.6368-6368, Article 6368

2023

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A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membrane

Molecular microbiology, 2023-06, Vol.119 (6), p.752-767

2023

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Thanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC–LptA Interaction and Decreasing LptA Stability

Frontiers in microbiology, 2020-05, Vol.11, p.909-909

2020

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Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development

Developmental biology, 2022-10, Vol.490, p.53-65

2022

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Residues within the LptC transmembrane helix are critical for Escherichia coli LptB2FG ATPase regulation

Protein science, 2024-02, Vol.33 (2), p.n/a

2024

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Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

Antimicrobial agents and chemotherapy, 2019-09, Vol.63 (9)

2019

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In silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD

Scientific reports, 2024-03, Vol.14 (1), p.7278-7278, Article 7278

2024

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The transmembrane α‐helix of LptC participates in LPS extraction by the LptB2FGC transporter

Molecular microbiology, 2022-07, Vol.118 (1-2), p.61-76

2022

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Residues within the LptC transmembrane helix are critical for Escherichia coli LptB 2 FG ATPase regulation

Protein science, 2024-02, Vol.33 (2)

2024

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Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis

Journal of bacteriology, 2016-02, Vol.198 (4), p.731-741

2016

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Early Molecular Insights into Thanatin Analogues Binding to A. baumannii LptA

Molecules (Basel, Switzerland), 2023-05, Vol.28 (11), p.4335

2023

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LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (26), p.9467-9472

2014

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The lipopolysaccharide-transporter complex LptB2FG also displays adenylate kinase activity in vitro dependent on the binding partners LptC/LptA

The Journal of biological chemistry, 2021-12, Vol.297 (6), p.101313-101313, Article 101313

2021

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The Prediction of LptA and LptC Protein-Protein Interactions and Virtual Screening for Potential Inhibitors

Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1827

2024

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Mutation and Suppressor Analysis of the Essential Lipopolysaccharide Transport Protein LptA Reveals Strategies To Overcome Severe Outer Membrane Permeability Defects in Escherichia coli

Journal of bacteriology, 2018-01, Vol.200 (2)

2018

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Lipopolysaccharide is Inserted into the Outer Membrane through An Intramembrane Hole, A Lumen Gate, and the Lateral Opening of LptD

Structure (London), 2015-03, Vol.23 (3), p.496-504

2015

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Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

Journal of Bacteriology, 2013-03, Vol.195 (5), p.1100-1108

2013

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Characterizing the interactions between the LPS transport protein LptC and the ABC transporter LptB2FG

Biophysical journal, 2023-02, Vol.122 (3), p.56a-56a

2023

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Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens

Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism

The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria

Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG

Binding and transport of LPS occurs through the coordinated combination of an array of sites across the entire Escherichia coli LPS transport protein LptA

Linking dual mode of action of host defense antimicrobial peptide thanatin: Structures, lipopolysaccharide and LptAm binding of designed analogs

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry

A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membrane

Thanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC–LptA Interaction and Decreasing LptA Stability

Lpt, trr, and Hcf regulate histone mono- and dimethylation that are essential for Drosophila heart development

Residues within the LptC transmembrane helix are critical for Escherichia coli LptB2FG ATPase regulation

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

In silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD

The transmembrane α‐helix of LptC participates in LPS extraction by the LptB2FGC transporter

Residues within the LptC transmembrane helix are critical for Escherichia coli LptB 2 FG ATPase regulation

Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis

Early Molecular Insights into Thanatin Analogues Binding to A. baumannii LptA

LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface

The lipopolysaccharide-transporter complex LptB2FG also displays adenylate kinase activity in vitro dependent on the binding partners LptC/LptA

The Prediction of LptA and LptC Protein-Protein Interactions and Virtual Screening for Potential Inhibitors

Mutation and Suppressor Analysis of the Essential Lipopolysaccharide Transport Protein LptA Reveals Strategies To Overcome Severe Outer Membrane Permeability Defects in Escherichia coli

Lipopolysaccharide is Inserted into the Outer Membrane through An Intramembrane Hole, A Lumen Gate, and the Lateral Opening of LptD

Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

Characterizing the interactions between the LPS transport protein LptC and the ABC transporter LptB2FG

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