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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Aging cell, 2014-06, Vol.13 (3), p.468-477

2014

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Nature (London), 2009-07, Vol.460 (7253), p.392-395

2009

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Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Aging cell, 2010-02, Vol.9 (1), p.92-95

2010

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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Aging cell, 2008-10, Vol.7 (5), p.641-650

2008

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Fat maintenance is a predictor of the murine lifespan response to dietary restriction

Aging cell, 2011-08, Vol.10 (4), p.629-639

2011

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Hyperadrenocorticism of calorie restriction contributes to its anti‐inflammatory action in mice

Aging cell, 2019-06, Vol.18 (3), p.e12944-n/a

2019

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Probing the relationship between insulin sensitivity and longevity using genetically modified mice

The journals of gerontology. Series A, Biological sciences and medical sciences, 2012-12, Vol.67 (12), p.1332-1338

2012

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Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension

Experimental gerontology, 2010-09, Vol.45 (9), p.691-701

2010

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An aging Interventions Testing Program: study design and interim report

Aging cell, 2007-08, Vol.6 (4), p.565-575

2007

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Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Aging cell, 2014-04, Vol.13 (2), p.273-282

2014

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Intra-organ variation in age-related mutation accumulation in the mouse

PloS one, 2007-09, Vol.2 (9), p.e876

2007

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Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice

Aging cell, 2023-08, Vol.22 (8), p.e13891-n/a

2023

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

The journals of gerontology. Series A, Biological sciences and medical sciences, 2011-02, Vol.66 (2), p.191-201

2011

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Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects

Aging cell, 2020-11, Vol.19 (11), p.e13269-n/a

2020

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Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

The journals of gerontology. Series A, Biological sciences and medical sciences, 2013-01, Vol.68 (1), p.6-16

2013

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Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Science (American Association for the Advancement of Science), 2022-09, Vol.377 (6614), p.eabo3191-eabo3191

2022

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Genetically heterogeneous mice exhibit a female survival advantage that is age‐ and site‐specific: Results from a large multi‐site study

Aging cell, 2019-06, Vol.18 (3), p.e12905-n/a

2019

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Acarbose improves health and lifespan in aging HET3 mice

Aging cell, 2019-04, Vol.18 (2), p.e12898-n/a

2019

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The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride

GeroScience, 2024-04, Vol.46 (5), p.4533-4541

2024

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Genetic cartography of longevity in humans and mice: Current landscape and horizons

Biochimica et biophysica acta. Molecular basis of disease, 2018-09, Vol.1864 (9), p.2718-2732

2018

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Castration reduces mortality and increases resilience in male mice: what is next?

GeroScience, 2024-04, Vol.46 (2), p.2787-2790

2024

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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Fat maintenance is a predictor of the murine lifespan response to dietary restriction

Hyperadrenocorticism of calorie restriction contributes to its anti‐inflammatory action in mice

Probing the relationship between insulin sensitivity and longevity using genetically modified mice

Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension

An aging Interventions Testing Program: study design and interim report

Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an [alpha]-glucosidase inhibitor or a Nrf2-inducer

Intra-organ variation in age-related mutation accumulation in the mouse

Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Genetically heterogeneous mice exhibit a female survival advantage that is age‐ and site‐specific: Results from a large multi‐site study

Acarbose improves health and lifespan in aging HET3 mice

The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride

Genetic cartography of longevity in humans and mice: Current landscape and horizons

Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice

Castration reduces mortality and increases resilience in male mice: what is next?

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