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Competition between target sites of regulators shapes post-transcriptional gene regulation

Nature reviews. Genetics, 2015-02, Vol.16 (2), p.113-126

2015

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Drug–target residence time and its implications for lead optimization

Nature reviews. Drug discovery, 2006-08, Vol.5 (9), p.730-739

2006

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Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry

Pharmacological research, 2021-10, Vol.172, p.105820-105820, Article 105820

2021

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Markov state modeling reveals alternative unbinding pathways for peptide–MHC complexes

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (48), p.30610-30618

2020

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Studies of eosin Y – DNA interaction using a competitive binding assay

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021-02, Vol.247, p.119114, Article 119114

2021

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Linking Transthyretin-Binding Chemicals and Free Thyroid Hormones: In Vitro to In Vivo Extrapolation Based on a Competitive Binding Model

Environmental science & technology, 2023-06, Vol.57 (25), p.9130-9139

2023

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Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL

Archives of biochemistry and biophysics, 2022-06, Vol.722, p.109236-109236, Article 109236

2022

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Argyrin B, a non‐competitive inhibitor of the human immunoproteasome exhibiting preference for β1i

Chemical biology & drug design, 2019-08, Vol.94 (2), p.1556-1567

2019

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Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Nature communications, 2021-11, Vol.12 (1), p.6321-6321, Article 6321

2021

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Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

Brain (London, England : 1878), 2013-07, Vol.136 (Pt 7), p.2217-2227

2013

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NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors

The Journal of pharmacology and experimental therapeutics, 2013-10, Vol.347 (1), p.69-79

2013

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Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.113, Article 113

2022

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Down‐regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin‐like growth factor 1 via microRNA‐130a

Journal of cellular and molecular medicine, 2020-01, Vol.24 (1), p.451-464

2020

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Direct Evidence Revealing Structural Elements Essential for the High Binding Ability of Bisphenol A to Human Estrogen-Related Receptor-γ

Environmental health perspectives, 2008-01, Vol.116 (1), p.32-38

2008

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Rapid generation of microRNA sponges for microRNA inhibition

PloS one, 2012-01, Vol.7 (1), p.e29275-e29275

2012

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A novel method for the study of molecular interaction by using microscale thermophoresis

Talanta (Oxford), 2015-01, Vol.132, p.894-901

2015

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The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors

Neuropharmacology, 2016-09, Vol.108, p.220-228

2016

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RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents

The Journal of pharmacology and experimental therapeutics, 2011-01, Vol.336 (1), p.242-253

2011

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Sex pheromone recognition and immunolocalization of three pheromone binding proteins in the black cutworm moth Agrotis ipsilon

Insect biochemistry and molecular biology, 2013-03, Vol.43 (3), p.237-251

2013

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Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

Journal of neurochemistry, 2009-09, Vol.110 (6), p.1942-1954

2009

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Biochemical mechanisms of drug action: what does it take for success?

Nature reviews. Drug discovery, 2004-09, Vol.3 (9), p.801-808

Swinney, David C

2004

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Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11 C]PHNO, and a Selective D3 Receptor Antagonist

Biological psychiatry (1969), 2010-08, Vol.68 (4), p.392-399

2010

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2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations

PloS one, 2011-02, Vol.6 (2), p.e16812-e16812

2011

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Dose-Response Analysis When There Is a Correlation between Affinity and Efficacy

Molecular pharmacology, 2016-02, Vol.89 (2), p.297-302

Auerbach, Anthony

2016

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Transcription factor target site search and gene regulation in a background of unspecific binding sites

Journal of theoretical biology, 2018-10, Vol.454, p.91-101

2018

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Competition between target sites of regulators shapes post-transcriptional gene regulation

Drug–target residence time and its implications for lead optimization

Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry

Markov state modeling reveals alternative unbinding pathways for peptide–MHC complexes

Studies of eosin Y – DNA interaction using a competitive binding assay

Linking Transthyretin-Binding Chemicals and Free Thyroid Hormones: In Vitro to In Vivo Extrapolation Based on a Competitive Binding Model

Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL

Argyrin B, a non‐competitive inhibitor of the human immunoproteasome exhibiting preference for β1i

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors

Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Down‐regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin‐like growth factor 1 via microRNA‐130a

Direct Evidence Revealing Structural Elements Essential for the High Binding Ability of Bisphenol A to Human Estrogen-Related Receptor-γ

Rapid generation of microRNA sponges for microRNA inhibition

A novel method for the study of molecular interaction by using microscale thermophoresis

The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT3 receptors

RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents

Sex pheromone recognition and immunolocalization of three pheromone binding proteins in the black cutworm moth Agrotis ipsilon

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

Biochemical mechanisms of drug action: what does it take for success?

Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11 C]PHNO, and a Selective D3 Receptor Antagonist

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations

Dose-Response Analysis When There Is a Correlation between Affinity and Efficacy

Transcription factor target site search and gene regulation in a background of unspecific binding sites

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