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Should the incorporation of structural alerts be restricted in drug design? An analysis of structure-toxicity trends with aniline-based drugs

Current medicinal chemistry, 2015-01, Vol.22 (4), p.438-464

Kalgutkar, A S

2015

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Transporter‐Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug–Drug Interactions of Montelukast

Clinical pharmacology and therapeutics, 2017-03, Vol.101 (3), p.406-415

2017

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Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2860-2870

2000

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Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors

Chemical research in toxicology, 2001-09, Vol.14 (9), p.1139-1162

2001

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Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

Science (American Association for the Advancement of Science), 1998-05, Vol.280 (5367), p.1268-1270

1998

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A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385

The Journal of biological chemistry, 2003-11, Vol.278 (46), p.45763-45769

2003

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A Semiquantitative Method for the Determination of Reactive Metabolite Conjugate Levels in Vitro Utilizing Liquid Chromatography−Tandem Mass Spectrometry and Novel Quaternary Ammonium Glutathione Analogues

Chemical research in toxicology, 2006-03, Vol.19 (3), p.480-490

2006

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A comprehensive listing of bioactivation pathways of organic functional groups

Current drug metabolism, 2005-06, Vol.6 (3), p.161-225

2005

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Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

Trends in Pharmacological Sciences, 1999-11, Vol.20 (11), p.465-469

1999

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Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

Xenobiotica, 2010-06, Vol.40 (6), p.369-380

2010

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Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

The Journal of biological chemistry, 1999-08, Vol.274 (33), p.22903

1999

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Biochemically Based Design of Cyclooxygenase-2 (COX-2) Inhibitors: Facile Conversion of Nonsteroidal Antiinflammatory Drugs to Potent and Highly Selective COX-2 Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2000-01, Vol.97 (2), p.925-930

2000

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Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators

Journal of medicinal chemistry, 1998-11, Vol.41 (24), p.4800-4818

1998

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Utility of multivariate analysis in support of in vitro metabolite identification studies: retrospective analysis using the antidepressant drug nefazodone

Xenobiotica, 2010-04, Vol.40 (4), p.262-274

2010

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Reactive Drug Metabolites

1, 2012

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Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents

Current drug targets, 2001-03, Vol.2 (1), p.79-106

2001

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On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics

Current drug metabolism, 2002-08, Vol.3 (4), p.379-424

2002

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Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates

Annual review of pharmacology and toxicology, 2015-01, Vol.55 (1), p.35-54

2015

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Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway

Drug metabolism and disposition, 2003-03, Vol.31 (3), p.243-249

2003

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Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor α agonist in preclinical species and human

Xenobiotica, 2009-10, Vol.39 (10), p.766-781

2009

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Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents

Current opinion in chemical biology, 1998-08, Vol.2 (4), p.482-490

1998

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Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species

Xenobiotica, 2004-08, Vol.34 (8), p.755-770

2004

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Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans

Drug metabolism and disposition, 2016-02, Vol.44 (2), p.209-219

2016

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Selective inhibitors of monoamine oxidase (MAO-A and MAO-B) as probes of its catalytic site and mechanism

Medicinal research reviews, 1995-07, Vol.15 (4), p.325-388

1995

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The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.692-699

2016

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Should the incorporation of structural alerts be restricted in drug design? An analysis of structure-toxicity trends with aniline-based drugs

Transporter‐Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug–Drug Interactions of Montelukast

Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors

Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2

A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385

A Semiquantitative Method for the Determination of Reactive Metabolite Conjugate Levels in Vitro Utilizing Liquid Chromatography−Tandem Mass Spectrometry and Novel Quaternary Ammonium Glutathione Analogues

A comprehensive listing of bioactivation pathways of organic functional groups

Cyclooxygenase 2 inhibitors: discovery, selectivity and the future

Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

Biochemically Based Design of Cyclooxygenase-2 (COX-2) Inhibitors: Facile Conversion of Nonsteroidal Antiinflammatory Drugs to Potent and Highly Selective COX-2 Inhibitors

Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators

Utility of multivariate analysis in support of in vitro metabolite identification studies: retrospective analysis using the antidepressant drug nefazodone

Reactive Drug Metabolites

Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents

On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics

Predicting Toxicities of Reactive Metabolite-Positive Drug Candidates

Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway

Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor α agonist in preclinical species and human

Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents

Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species

Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans

Selective inhibitors of monoamine oxidase (MAO-A and MAO-B) as probes of its catalytic site and mechanism

The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy

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