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Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes

Molecular cancer therapeutics, 2019-12, Vol.18 (12), p.2394-2406

2019

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The structure of the ternary Eg5-ADP-ispinesib complex

Acta crystallographica. Section D, Biological crystallography., 2012-10, Vol.68 (10), p.1311-1319

2012

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New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations

Bioorganic & medicinal chemistry, 2016-02, Vol.24 (4), p.721-734

2016

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Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 by an Allosteric Resistance Mechanism

Journal of medicinal chemistry, 2013-08, Vol.56 (16), p.6317-6329

2013

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The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

eLife, 2015-04, Vol.4

2015

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Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

Acta crystallographica. Section D, Biological crystallography., 2013-09, Vol.69 (9), p.1780-1788

2013

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Nimotuzumab and Intensity Modulated Radiation Therapy (IMRT) in the Concurrent Setting of Locally Advanced Head and Neck Cancers: Early Results of a Prospective Trial in India

International journal of radiation oncology, biology, physics, 2016-10, Vol.96 (2), p.E359-E359

2016

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Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Biology open, 2019, Vol.8 (1)

2019

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Modified Peptide Inhibitors of the Keap1–Nrf2 Protein–Protein Interaction Incorporating Unnatural Amino Acids

Chembiochem : a European journal of chemical biology, 2018-09, Vol.19 (17), p.1810-1816

2018

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Comparison of Invasive and Noninvasive Frame for Set-up Error Accuracy in Intracranial Radiation Therapy—An Indian Institute Experience

International journal of radiation oncology, biology, physics, 2016-10, Vol.96 (2), p.E132-E133

2016

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The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation

Journal of cell science, 2019-01, Vol.132 (4)

2019

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Dosimetric and Toxicity Results of Intensity-modulated Radiotherapy for Locally Advanced Pancreatic Cancer from a Single Institute

Clinical oncology (Royal College of Radiologists (Great Britain)), 2017-03, Vol.29 (3), p.e82-e82

2017

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Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

European journal of medicinal chemistry, 2018-08, Vol.156, p.641-651

2018

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Comparison of magnetic resonance imaging-fluorodeoxyglucose positron emission tomography fusion with pathological staging in rectal cancer (Br J Surg 2010; 97: 266-268)

British journal of surgery, 2010-07, Vol.97 (7), p.1151-1151

2010

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Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein

Journal of the American Chemical Society, 2013-02, Vol.135 (6), p.2263-2272

2013

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Design, 3D printing and validation of a novel low‐cost high‐capacity sitting‐drop bridge for protein crystallization

Journal of applied crystallography, 2019-02, Vol.52 (1), p.171-174

2019

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Depsidones from Lichens as Natural Product Inhibitors of M‑Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis

Journal of natural products (Washington, D.C.), 2016-06, Vol.79 (6), p.1576-1585

2016

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The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping

Oncotarget, 2018-01, Vol.9 (3), p.3160-3171

2018

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1224 poster EVALUATION OF AUTOMATED IMAGE REGISTRATION ALGORITHM AND ON-BOARD IMAGER FOR IMAGE GUIDED RADIOTHERAPY (IGRT)

Radiotherapy and oncology, 2011, Vol.99, p.S456-S456

2011

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SU‐GG‐T‐213: Portal Dosimetry for Pre‐Treatment Verification of IMRT Plan: A Comparison with 2D Ion Chamber Array

Medical Physics, 2010-06, Vol.37 (6), p.3234-3234

2010

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Optimized S‑Trityl‑l‑cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models

Journal of medicinal chemistry, 2013-03, Vol.56 (5), p.1878-1893

2013

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Indolobenzazepin-7-ones and 6-, 8-, and 9-Membered Ring Derivatives as Tubulin Polymerization Inhibitors: Synthesis and Structure−Activity Relationship Studies

Journal of medicinal chemistry, 2009-10, Vol.52 (19), p.5916-5925

2009

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Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapy (Br J Surg 2008; 95: 206-213)

British journal of surgery, 2008-06, Vol.95 (6), p.802-803

2008

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PO-0852: Can we ignore Submandibular gland constraints for Xerostomia prevention in Parotid sparing IMRT?

Radiotherapy and oncology, 2020-11, Vol.152, p.S459-S459

2020

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Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil

Journal of cancer research and therapeutics, 2007-07, Vol.3 (3), p.169

2007

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Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes

The structure of the ternary Eg5-ADP-ispinesib complex

New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations

Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 by an Allosteric Resistance Mechanism

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

Nimotuzumab and Intensity Modulated Radiation Therapy (IMRT) in the Concurrent Setting of Locally Advanced Head and Neck Cancers: Early Results of a Prospective Trial in India

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Modified Peptide Inhibitors of the Keap1–Nrf2 Protein–Protein Interaction Incorporating Unnatural Amino Acids

Comparison of Invasive and Noninvasive Frame for Set-up Error Accuracy in Intracranial Radiation Therapy—An Indian Institute Experience

The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation

Dosimetric and Toxicity Results of Intensity-modulated Radiotherapy for Locally Advanced Pancreatic Cancer from a Single Institute

Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

Comparison of magnetic resonance imaging-fluorodeoxyglucose positron emission tomography fusion with pathological staging in rectal cancer (Br J Surg 2010; 97: 266-268)

Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein

Design, 3D printing and validation of a novel low‐cost high‐capacity sitting‐drop bridge for protein crystallization

Depsidones from Lichens as Natural Product Inhibitors of M‑Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis

The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping

1224 poster EVALUATION OF AUTOMATED IMAGE REGISTRATION ALGORITHM AND ON-BOARD IMAGER FOR IMAGE GUIDED RADIOTHERAPY (IGRT)

SU‐GG‐T‐213: Portal Dosimetry for Pre‐Treatment Verification of IMRT Plan: A Comparison with 2D Ion Chamber Array

Optimized S‑Trityl‑l‑cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models

Indolobenzazepin-7-ones and 6-, 8-, and 9-Membered Ring Derivatives as Tubulin Polymerization Inhibitors: Synthesis and Structure−Activity Relationship Studies

Late gastrointestinal disorders after rectal cancer surgery with and without preoperative radiation therapy (Br J Surg 2008; 95: 206-213)

PO-0852: Can we ignore Submandibular gland constraints for Xerostomia prevention in Parotid sparing IMRT?

Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil

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