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How structure defines affinity in protein-protein interactions

PloS one, 2014-10, Vol.9 (10), p.e110085-e110085

2014

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Cold Spot SCANNER: Colab Notebook for predicting cold spots in protein-protein interfaces

BMC bioinformatics, 2024-04, Vol.25 (1), p.172-172, Article 172

2024

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RAS/Effector Interactions from Structural and Biophysical Perspective

Mini reviews in medicinal chemistry, 2016-03, Vol.16 (5), p.370

2016

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Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization

Nature communications, 2020-01, Vol.11 (1), p.297-297, Article 297

2020

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Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering

Journal of structural biology, 2011-08, Vol.175 (2), p.171-177

2011

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Analysis of Structural Features Contributing to Weak Affinities of Ubiquitin/Protein Interactions

Journal of molecular biology, 2017-11, Vol.429 (22), p.3353-3362

2017

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Tradeoff between stability and multispecificity in the design of promiscuous proteins

PLoS computational biology, 2009-12, Vol.5 (12), p.e1000627

2009

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Predicting affinity- and specificity-enhancing mutations at protein-protein interfaces

Biochemical Society transactions, 2013-10, Vol.41 (5), p.1166

2013

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A single-tube assembly of DNA using the transfer-PCR (TPCR) platform

Methods in molecular biology (Clifton, N.J.), 2014-01, Vol.1116, p.89

2014

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Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) Is Activated by Calmodulin with Two Bound Calciums

Proceedings of the National Academy of Sciences - PNAS, 2006-09, Vol.103 (38), p.13968-13973

2006

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Computational design and experimental optimization of protein binders with prospects for biomedical applications

Protein engineering, design and selection, 2021-08, Vol.34

2021

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Targeting Ras with protein engineering

Oncotarget, 2023-07, Vol.14 (1), p.672-687

2023

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Cold Spots in Protein Binding

Trends in biochemical sciences (Amsterdam. Regular ed.), 2016-09, Vol.41 (9), p.739-745

2016

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Exploring the Origins of Binding Specificity through the Computational Redesign of Calmodulin

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (23), p.13274-13279

2003

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Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

The Journal of biological chemistry, 2017-02, Vol.292 (8), p.3481-3495

2017

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Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (31), p.8705-8710

2016

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Protein Engineering by Combined Computational and In Vitro Evolution Approaches

Trends in biochemical sciences (Amsterdam. Regular ed.), 2016-05, Vol.41 (5), p.421-433

2016

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Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma

The Journal of biological chemistry, 2021-12, Vol.297 (6), p.101353, Article 101353

2021

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Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein–Protein Complexes

Journal of the American Chemical Society, 2021-10, Vol.143 (41), p.17261-17275

2021

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Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor

Journal of molecular biology, 2023-07, Vol.435 (13), p.168095, Article 168095

2023

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Cold spots are universal in protein–protein interactions

Protein science, 2022-10, Vol.31 (10), p.e4435-n/a

2022

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Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14

FEBS letters, 2018-04, Vol.592 (7), p.1122-1134

2018

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Editorial overview: Engineering and design: New trends in designer proteins

Current opinion in structural biology, 2017-08, Vol.45, p.iv-vi

2017

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Multispecific Recognition: Mechanism, Evolution, and Design

Biochemistry (Easton), 2011-02, Vol.50 (5), p.602-611

2011

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Combinatorial and Computational Approaches to Identify Interactions of Macrophage Colony-stimulating Factor (M-CSF) and Its Receptor c-FMS

The Journal of biological chemistry, 2015-10, Vol.290 (43), p.26180-26193

2015

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How structure defines affinity in protein-protein interactions

Cold Spot SCANNER: Colab Notebook for predicting cold spots in protein-protein interfaces

RAS/Effector Interactions from Structural and Biophysical Perspective

Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization

Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering

Analysis of Structural Features Contributing to Weak Affinities of Ubiquitin/Protein Interactions

Tradeoff between stability and multispecificity in the design of promiscuous proteins

Predicting affinity- and specificity-enhancing mutations at protein-protein interfaces

A single-tube assembly of DNA using the transfer-PCR (TPCR) platform

Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) Is Activated by Calmodulin with Two Bound Calciums

Computational design and experimental optimization of protein binders with prospects for biomedical applications

Targeting Ras with protein engineering

Cold Spots in Protein Binding

Exploring the Origins of Binding Specificity through the Computational Redesign of Calmodulin

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21

Protein Engineering by Combined Computational and In Vitro Evolution Approaches

Engineered variants of the Ras effector protein RASSF5 (NORE1A) promote anticancer activities in lung adenocarcinoma

Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein–Protein Complexes

Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix MetalloproteinaseInhibitor

Cold spots are universal in protein–protein interactions

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14

Editorial overview: Engineering and design: New trends in designer proteins

Multispecific Recognition: Mechanism, Evolution, and Design

Combinatorial and Computational Approaches to Identify Interactions of Macrophage Colony-stimulating Factor (M-CSF) and Its Receptor c-FMS

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