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Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix

Spine (Philadelphia, Pa. 1976), 2004-12, Vol.29 (23), p.2691-2699

Roughley, Peter J

2004

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What is intervertebral disc degeneration, and what causes it?

Spine (Philadelphia, Pa. 1976), 2006-08, Vol.31 (18), p.2151-2161

2006

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The role of aggrecan in normal and osteoarthritic cartilage

Journal of experimental orthopaedics, 2014-12, Vol.1 (1), p.8-11, Article 8

2014

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Cartilage in normal and osteoarthritis conditions

Best practice & research. Clinical rheumatology, 2008-04, Vol.22 (2), p.351-384

2008

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Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

Annals of the rheumatic diseases, 2015-07, Vol.74 (7), p.1432-1440

2015

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TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs

PloS one, 2015-03, Vol.10 (3), p.e0118358-e0118358

2015

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The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration

Arthritis research & therapy, 2011-07, Vol.13 (4), p.R120-R120

2011

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Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains

Journal of structural biology, 2013-03, Vol.181 (3), p.264-273

2013

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SLRP interaction can protect collagen fibrils from cleavage by collagenases

Matrix biology, 2006-10, Vol.25 (8), p.484-491

2006

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Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc

Spine (Philadelphia, Pa. 1976), 2011-10, Vol.36 (22), p.1835-1842

2011

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MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

Matrix biology, 2011-03, Vol.30 (2), p.145-153

2011

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Physiological loading can restore the proteoglycan content in a model of early IVD degeneration

PloS one, 2014-07, Vol.9 (7), p.e101233-e101233

2014

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Limitations of using aggrecan and type X collagen as markers of chondrogenesis in mesenchymal stem cell differentiation

Journal of orthopaedic research, 2006-08, Vol.24 (8), p.1791-1798

2006

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Extracellular matrix composition in COPD

The European respiratory journal, 2012-12, Vol.40 (6), p.1362-1373

2012

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Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis

BMC musculoskeletal disorders, 2016-02, Vol.17 (89), p.89-89, Article 89

2016

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Short Link N promotes disc repair in a rabbit model of disc degeneration

Arthritis research & therapy, 2018-08, Vol.20 (1), p.201-201, Article 201

2018

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Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability

The spine journal, 2015-05, Vol.15 (5), p.1060-1069

2015

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mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (5), p.2054-2059

2010

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In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression

Journal of orthopaedic research, 2009-09, Vol.27 (9), p.1235-1242

2009

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Cortical and Trabecular Bone Density in X-Linked Hypophosphatemic Rickets

The journal of clinical endocrinology and metabolism, 2013-05, Vol.98 (5), p.E954-E961

2013

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Calcification in human intervertebral disc degeneration and scoliosis

Journal of orthopaedic research, 2011-12, Vol.29 (12), p.1888-1895

2011

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The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells

Arthritis research & therapy, 2012-12, Vol.14 (6), p.R267-R267

2012

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Genotype-phenotype correlations in nonlethal osteogenesis imperfecta caused by mutations in the helical domain of collagen type I

European journal of human genetics : EJHG, 2010-06, Vol.18 (6), p.642-647

2010

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Tumor necrosis factorα modulates matrix production and catabolism in nucleus pulposus tissue

Spine (Philadelphia, Pa. 1976), 2005-09, Vol.30 (17), p.1940-1948

2005

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Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix

What is intervertebral disc degeneration, and what causes it?

The role of aggrecan in normal and osteoarthritic cartilage

Cartilage in normal and osteoarthritis conditions

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs

The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration

Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains

SLRP interaction can protect collagen fibrils from cleavage by collagenases

Development of an Organ Culture System for Long-Term Survival of the Intact Human Intervertebral Disc

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

Physiological loading can restore the proteoglycan content in a model of early IVD degeneration

Limitations of using aggrecan and type X collagen as markers of chondrogenesis in mesenchymal stem cell differentiation

Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans

Extracellular matrix composition in COPD

Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis

Short Link N promotes disc repair in a rabbit model of disc degeneration

Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability

mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes

In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression

Cortical and Trabecular Bone Density in X-Linked Hypophosphatemic Rickets

Calcification in human intervertebral disc degeneration and scoliosis

The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells

Genotype-phenotype correlations in nonlethal osteogenesis imperfecta caused by mutations in the helical domain of collagen type I

Tumor necrosis factorα modulates matrix production and catabolism in nucleus pulposus tissue

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