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Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit

Antimicrobial agents and chemotherapy, 2015-03, Vol.59 (3), p.1569-1582

2015

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Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

eLife, 2020-11, Vol.9

2020

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Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs

PloS one, 2013-09, Vol.8 (9), p.e75351

2013

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Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model

ACS medicinal chemistry letters, 2019-11, Vol.10 (11), p.1579-1585

2019

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Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ

Journal of medicinal chemistry, 2015-07, Vol.58 (14), p.5684-5688

2015

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Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (9), p.1990-1994

2015

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Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

Science advances, 2022-07, Vol.8 (27), p.eabj5633-eabj5633

2022

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Novel 2‑Substituted 7‑Azaindole and 7‑Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.261-265

2017

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Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6668-6678

2014

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Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones

Journal of organic chemistry, 1996-05, Vol.61 (9), p.3214-3217

1996

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Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C

Journal of the American Chemical Society, 1999-12, Vol.121 (49), p.11375-11383

1999

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Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.256-260

2017

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Total Synthesis of Quinoxapeptin A-C: Establishment of Absolute Stereochemistry

Angewandte Chemie International Edition, 1999-08, Vol.38 (16), p.2424-2426

1999

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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.153-156

2010

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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7938-7941

2009

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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7195-7216

2015

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Total Synthesis of Luzopeptins A−C

Journal of the American Chemical Society, 1999-02, Vol.121 (5), p.1098-1099

1999

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Vicarious calibration experiment in support of the Multi-angle Imaging SpectroRadiometer

IEEE transactions on geoscience and remote sensing, 2002-07, Vol.40 (7), p.1500-1511

2002

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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6529-6533

2009

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The Airborne Multi-angle Imaging SpectroRadiometer (AirMISR): instrument description and first results

IEEE transactions on geoscience and remote sensing, 1998-07, Vol.36 (4), p.1339-1349

1998

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Vicarious calibration: A reflectance-based experiment with AirMISR

Remote sensing of environment, 2001-09, Vol.77 (3), p.338-353

2001

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Corrigendum to “Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors” [Bioorg. Med. Chem. Lett. 25 (2015) 1990–1994]

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (1), p.240-240

2016

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Corrigendum to “A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 153]

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2684-2684

2010

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Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs: e75351

PloS one, 2013-09, Vol.8 (9)

2013

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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors T.W. would like to dedicate this Letter to his PhD mentor, Professor Zhengming Li of Nankai University, Tianjin, China, in honor of his more than 50 years of teaching and research in organic chemistry

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (1), p.153-156

2010

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Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs

Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model

Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ

Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors

Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

Novel 2‑Substituted 7‑Azaindole and 7‑Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones

Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C

Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2

Total Synthesis of Quinoxapeptin A-C: Establishment of Absolute Stereochemistry

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases

Total Synthesis of Luzopeptins A−C

Vicarious calibration experiment in support of the Multi-angle Imaging SpectroRadiometer

2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2

The Airborne Multi-angle Imaging SpectroRadiometer (AirMISR): instrument description and first results

Vicarious calibration: A reflectance-based experiment with AirMISR

Corrigendum to “Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors” [Bioorg. Med. Chem. Lett. 25 (2015) 1990–1994]

Corrigendum to “A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 153]

Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs: e75351

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