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Measurement and meaning of cellular thiol:disufhide redox status

Free radical research, 2016-02, Vol.50 (2), p.246-271

Comini, Marcelo A.

2016

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Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

Journal of molecular biology, 2019-05, Vol.431 (11), p.2143-2162

2019

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The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

Current medicinal chemistry, 2019-01, Vol.26 (36), p.6614-6635

2019

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Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Molecules (Basel, Switzerland), 2023-01, Vol.28 (3), p.1276

2023

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Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

European journal of medicinal chemistry, 2020-03, Vol.189, p.112043, Article 112043

2020

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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Biochimica et biophysica acta, 2008-11, Vol.1780 (11), p.1236-1248

2008

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Alternative Thiol-Based Redox Systems

Antioxidants & redox signaling, 2018-02, Vol.28 (6), p.407-409

2018

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A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes

Drug development research, 2022-04, Vol.83 (2), p.253-263

2022

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Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

Sensors (Basel, Switzerland), 2022-02, Vol.22 (4), p.1324

2022

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Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

Biochemical and biophysical research communications, 2022-12, Vol.637, p.308-313

2022

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Organocatalytic Synthesis and Anti‐Trypanosomal Activity Evaluation of L‐Pentofuranose‐Mimetic Iminosugars

European journal of organic chemistry, 2022-09, Vol.2022 (34), p.n/a

2022

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The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

PloS one, 2023-11, Vol.18 (11), p.e0292946-e0292946

2023

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Molecules (Basel, Switzerland), 2021-01, Vol.26 (2), p.358

2021

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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

PLoS neglected tropical diseases, 2016-04, Vol.10 (4), p.e0004617-e0004617

2016

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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

PLoS pathogens, 2019-09, Vol.15 (9), p.e1008065-e1008065

2019

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Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions

Antioxidants & redox signaling, 2018-02, Vol.28 (6), p.463-486

2018

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Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules (Basel, Switzerland), 2016-03, Vol.21 (3), p.368

2016

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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.912-929

2022

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Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Frontiers in cellular and infection microbiology, 2023-03, Vol.13, p.1082524-1082524

2023

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Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes

Antioxidants & redox signaling, 2013-09, Vol.19 (7), p.708-722

2013

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Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Biochemical journal, 2007-02, Vol.402 (1), p.43-49

2007

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Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

PLoS pathogens, 2014-04, Vol.10 (4), p.e1004075-e1004075

2014

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In vitro activity and mode of action of distamycin analogues against African trypanosomes

European journal of medicinal chemistry, 2017-01, Vol.126, p.776-788

2017

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Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

European journal of medicinal chemistry, 2023-01, Vol.246, p.114926-114926, Article 114926

2023

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Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International journal for parasitology -- drugs and drug resistance, 2024-04, Vol.24, p.100529-100529, Article 100529

2024

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Measurement and meaning of cellular thiol:disufhide redox status

Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Alternative Thiol-Based Redox Systems

A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes

Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

Organocatalytic Synthesis and Anti‐Trypanosomal Activity Evaluation of L‐Pentofuranose‐Mimetic Iminosugars

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes

Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

In vitro activity and mode of action of distamycin analogues against African trypanosomes

Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

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