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The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses

Autophagy, 2021-05, Vol.17 (5), p.1142-1156

2021

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MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

Science (American Association for the Advancement of Science), 2018-04, Vol.360 (6386), p.336-341

2018

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Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

The EMBO journal, 2016-08, Vol.35 (15), p.1677-1693

2016

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MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

Nature (London), 2017-02, Vol.542 (7641), p.372-376

2017

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Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

eLife, 2018-04, Vol.7

2018

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Mfn2 is critical for brown adipose tissue thermogenic function

The EMBO journal, 2017-06, Vol.36 (11), p.1543-1558

2017

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Regulation of ER-mitochondria contacts by Parkin via Mfn2

Pharmacological research, 2018-12, Vol.138, p.43-56

2018

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MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming

British journal of cancer, 2020-01, Vol.122 (2), p.209-220

2020

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Mfn2 modulates the UPR and mitochondrial function via repression of PERK

The EMBO journal, 2013-08, Vol.32 (17), p.2348-2361

2013

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Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling

Cellular and molecular life sciences : CMLS, 2022-11, Vol.79 (11), p.573-573, Article 573

2022

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Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy

Theranostics, 2019-01, Vol.9 (13), p.3687-3706

2019

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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (14), p.5523-5528

2012

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Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis

Environmental research, 2020-09, Vol.188, p.109824, Article 109824

2020

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The Agency Model and MFN Clauses

The Review of economic studies, 2017-07, Vol.84 (3 (300)), p.1151-1185

JOHNSON, JUSTIN P.

2017

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Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis

Theranostics, 2020, Vol.10 (3), p.1415-1432

2020

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Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Journal of agricultural and food chemistry, 2024-04, Vol.72 (13), p.7411-7422

2024

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Data-driven physics-informed constitutive metamodeling of complex fluids: A multifidelity neural network (MFNN) framework

Journal of rheology (New York : 1978), 2021-03, Vol.65 (2), p.179-198

2021

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The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics

Redox biology, 2021-05, Vol.41, p.101910-101910, Article 101910

2021

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MFN2 mutations in Charcot–Marie–Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics

Human molecular genetics, 2019-06, Vol.28 (11), p.1782-1800

2019

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MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

Biochimica et biophysica acta. Molecular basis of disease, 2018-09, Vol.1864 (9), p.2859-2870

2018

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Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease

Free radical biology & medicine, 2020-06, Vol.153, p.89-102

2020

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MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis

Osteoarthritis and cartilage, 2020-08, Vol.28 (8), p.1079-1091

2020

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Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway

Free radical biology & medicine, 2022-04, Vol.183, p.75-88

2022

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MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

Scientific reports, 2017-02, Vol.7 (1), p.41718-41718, Article 41718

2017

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Mfn2 is involved in intervertebral disc degeneration through autophagy modulation

Osteoarthritis and cartilage, 2020-03, Vol.28 (3), p.363-374

2020

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The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Mfn2 is critical for brown adipose tissue thermogenic function

Regulation of ER-mitochondria contacts by Parkin via Mfn2

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling

Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis

The Agency Model and MFN Clauses

Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis

Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Data-driven physics-informed constitutive metamodeling of complex fluids: A multifidelity neural network (MFNN) framework

The lncRNA Malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics

MFN2 mutations in Charcot–Marie–Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease

MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis

Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

Mfn2 is involved in intervertebral disc degeneration through autophagy modulation

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