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Using Nature’s “Tricks” To Rationally Tune the Binding Properties of Biomolecular Receptors

Accounts of chemical research, 2016-09, Vol.49 (9), p.1884-1892

2016

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Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (42), p.15048-15053

2014

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Chiral Electronic Transitions in Fluorescent Silver Clusters Stabilized by DNA

ACS nano, 2014-07, Vol.8 (7), p.6883-6892

2014

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Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure

Chemical science (Cambridge), 2016-01, Vol.7 (2), p.1200-1204

2016

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Effects of Crowding on the Stability of a Surface-Tethered Biopolymer: An Experimental Study of Folding in a Highly Crowded Regime

Journal of the American Chemical Society, 2014-06, Vol.136 (25), p.8923-8927

2014

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Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (21), p.6631-6636

2015

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Synthetic evolution

Nature biotechnology, 2019-07, Vol.37 (7), p.730-743

2019

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Retrons and their applications in genome engineering

Nucleic acids research, 2019-12, Vol.47 (21), p.11007-11019

2019

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Recent advances in synthetic biosafety

F1000 research, 2016, Vol.5, p.2118

2016

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Supercharging enables organized assembly of synthetic biomolecules

Nature chemistry, 2019-03, Vol.11 (3), p.204-212

2019

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Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel

Analyst (London), 2018-06, Vol.143 (11), p.2531-2538

2018

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Retroelement-Based Genome Editing and Evolution

ACS synthetic biology, 2018-11, Vol.7 (11), p.2600-2611

2018

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Using the Population-Shift Mechanism to Rationally Introduce "Hill-type" Cooperativity into a Normally Non-Cooperative Receptor

Angewandte Chemie International Edition, 2014-09, Vol.53 (36), p.9471-9475

International ed. in English, 2014

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Simultaneous Measurement of the Dissolution Kinetics of Responsive DNA Hydrogels at Multiple Length Scales

ACS nano, 2017-01, Vol.11 (1), p.461-468

2017

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Optimizing the Specificity Window of Biomolecular Receptors Using Structure-Switching and Allostery

ACS sensors, 2020-07, Vol.5 (7), p.1937-1942

2020

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Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors

ACS synthetic biology, 2019-09, Vol.8 (9), p.2017-2024

2019

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Real Time in Vitro Regulation of DNA Methylation Using a 5‑Fluorouracil Conjugated DNA-Based Stimuli-Responsive Platform

ACS applied materials & interfaces, 2013-04, Vol.5 (7), p.2604-2609

2013

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Culture and Human Rights: The Wroclaw Commentaries

1st edition., 2016

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Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogelElectronic supplementary information (ESI) available: Materials, methods, figures and code. See DOI: 10.1039/c8an00337h

2018-05

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Using the Population-Shift Mechanism to Rationally Introduce "Hill-type" Cooperativity into a Normally Non-Cooperative Receptor

Angewandte Chemie, 2014-09, Vol.126 (36), p.9625-9629

2014

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A Disorder-Based Strategy for the Introduction of Allosteric, “Hill-Type” Cooperativity into Artificial Receptors

Biophysical journal, 2015-01, Vol.108 (2), p.115a-115a

2015

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Principles for the Rational Design of Allosterically Cooperative Biomolecular Receptors

Biophysical journal, 2014-01, Vol.106 (2), p.614a-614a

2014

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Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructureElectronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03705k

2016-01

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Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03705k

Chemical science (Cambridge), 2015-10, Vol.7 (2), p.1200-1204

2015

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Abstract 2731: STX-001, a locally administered LNP-formulated self-replicating mRNA that encodes the therapeutic payload IL-12, induces deep systemic immune responses to solid tumors

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2731-2731

2023

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Using Nature’s “Tricks” To Rationally Tune the Binding Properties of Biomolecular Receptors

Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors

Chiral Electronic Transitions in Fluorescent Silver Clusters Stabilized by DNA

Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure

Effects of Crowding on the Stability of a Surface-Tethered Biopolymer: An Experimental Study of Folding in a Highly Crowded Regime

Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions

Synthetic evolution

Retrons and their applications in genome engineering

Recent advances in synthetic biosafety

Supercharging enables organized assembly of synthetic biomolecules

Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel

Retroelement-Based Genome Editing and Evolution

Using the Population-Shift Mechanism to Rationally Introduce "Hill-type" Cooperativity into a Normally Non-Cooperative Receptor

Simultaneous Measurement of the Dissolution Kinetics of Responsive DNA Hydrogels at Multiple Length Scales

Optimizing the Specificity Window of Biomolecular Receptors Using Structure-Switching and Allostery

Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors

Real Time in Vitro Regulation of DNA Methylation Using a 5‑Fluorouracil Conjugated DNA-Based Stimuli-Responsive Platform

Culture and Human Rights: The Wroclaw Commentaries

Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogelElectronic supplementary information (ESI) available: Materials, methods, figures and code. See DOI: 10.1039/c8an00337h

Using the Population-Shift Mechanism to Rationally Introduce "Hill-type" Cooperativity into a Normally Non-Cooperative Receptor

A Disorder-Based Strategy for the Introduction of Allosteric, “Hill-Type” Cooperativity into Artificial Receptors

Principles for the Rational Design of Allosterically Cooperative Biomolecular Receptors

Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructureElectronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03705k

Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03705k

Abstract 2731: STX-001, a locally administered LNP-formulated self-replicating mRNA that encodes the therapeutic payload IL-12, induces deep systemic immune responses to solid tumors

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