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IGF binding proteins in cancer: mechanistic and clinical insights

Nature reviews. Cancer, 2014-05, Vol.14 (5), p.329-341

Baxter, Robert C

2014

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Insulin and IGF receptor signalling in neural-stem-cell homeostasis

Nature reviews. Endocrinology, 2015-03, Vol.11 (3), p.161-170

2015

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The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nature medicine, 2012-11, Vol.18 (11), p.1643-1650

2012

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Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

Nature communications, 2015-04, Vol.6 (1), p.6780-6780, Article 6780

2015

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A critical role for IGF-II in memory consolidation and enhancement

Nature (London), 2011-01, Vol.469 (7331), p.491-497

2011

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Oxygen-Induced Retinopathy in Mice : Amplification by Neonatal IGF-I Deficit and Attenuation by IGF-I Administration

Pediatric research, 2009-03, Vol.65 (3), p.307-310

2009

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TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Nature communications, 2015-08, Vol.6 (1), p.7951-7951, Article 7951

2015

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IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

Scientific reports, 2016-10, Vol.6 (1), p.34605-34605, Article 34605

2016

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Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Nature communications, 2022-09, Vol.13 (1), p.5415-22, Article 5415

2022

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Determinants of IGF-II influencing stability, receptor binding and activation

Scientific reports, 2022-03, Vol.12 (1), p.4695-4695, Article 4695

2022

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IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

Nature neuroscience, 2006-11, Vol.9 (11), p.1371-1381

2006

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Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes

Nature genetics, 2006-05, Vol.38 (5), p.583-588

2006

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Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Nature communications, 2023-10, Vol.14 (1), p.6271-6271, Article 6271

2023

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rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

Gene therapy, 2016-03, Vol.23 (3), p.247-255

2016

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The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization

Scientific reports, 2024-08, Vol.14 (1), p.20161-13, Article 20161

2024

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ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

Cell death and differentiation, 2014-08, Vol.21 (8), p.1262-1274

2014

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IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts

Scientific reports, 2024-09, Vol.14 (1), p.20699-14, Article 20699

2024

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Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties

Scientific reports, 2018-11, Vol.8 (1), p.17361-13, Article 17361

2018

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p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure

Cell death & disease, 2017-08, Vol.8 (8), p.e2990-e2990

2017

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Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

Gene therapy, 2020-02, Vol.27 (1-2), p.62-73

2020

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IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition

Oncogene, 2001-08, Vol.20 (36), p.4942-4950

2001

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Placental-specific IGF-II is a major modulator of placental and fetal growth

Nature (London), 2002-06, Vol.417 (6892), p.945-948

2002

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Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death

Cell death & disease, 2016-11, Vol.7 (11), p.e2455-e2455

2016

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Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

Gene therapy, 2014-09, Vol.21 (9), p.811-819

2014

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Inhibition of IGF-I-related intracellular signaling pathways by proinflammatory cytokines in growth plate chondrocytes

Pediatric research, 2014-09, Vol.76 (3), p.245-251

2014

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IGF binding proteins in cancer: mechanistic and clinical insights

Insulin and IGF receptor signalling in neural-stem-cell homeostasis

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

A critical role for IGF-II in memory consolidation and enhancement

Oxygen-Induced Retinopathy in Mice : Amplification by Neonatal IGF-I Deficit and Attenuation by IGF-I Administration

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Determinants of IGF-II influencing stability, receptor binding and activation

IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes

Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization

ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts

Enhanced anti-metastatic bioactivity of an IGF-TRAP re-engineered to improve physicochemical properties

p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

IGF-II induces rapid β-catenin relocation to the nucleus during epithelium to mesenchyme transition

Placental-specific IGF-II is a major modulator of placental and fetal growth

Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

Inhibition of IGF-I-related intracellular signaling pathways by proinflammatory cytokines in growth plate chondrocytes

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