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Optimization of benzenesulfonyl derivatives as anti-Trypanosomatidae agents: Structural design, synthesis, and pharmacological assessment against Trypanosoma cruzi and Leishmania infantum

Bioorganic & medicinal chemistry, 2024-05, Vol.105, p.117736-117736, Article 117736

2024

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Design, synthesis, evaluation and optimization of novel azole analogues as potent antifungal agents

Bioorganic & medicinal chemistry, 2024-01, Vol.97, p.117543-117543, Article 117543

2024

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Novel xanthone antibacterials: Semi-synthesis, biological evaluation, and the action mechanisms

Bioorganic & medicinal chemistry, 2023-04, Vol.83, p.117232-117232, Article 117232

2023

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Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors

Bioorganic & medicinal chemistry, 2023-02, Vol.80, p.117187-117187, Article 117187

2023

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Synthesis and evaluation of enantiomers of hydroxychloroquine against SARS-CoV-2 in vitro

Bioorganic & medicinal chemistry, 2022-01, Vol.53, p.116523-116523, Article 116523

2022

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Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors

Bioorganic & medicinal chemistry, 2021-12, Vol.51, p.116507-116507, Article 116507

2021

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Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies

Bioorganic & medicinal chemistry, 2021-11, Vol.50, p.116458-116458, Article 116458

2021

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Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents

Bioorganic & medicinal chemistry, 2021-11, Vol.49, p.116426-116426, Article 116426

2021

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Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors

Bioorganic & medicinal chemistry, 2021-10, Vol.48, p.116418-116418, Article 116418

2021

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In vitro, ex vivo and in vivo short-term screening of DHEA nitrate derivatives activity over Trypanosoma cruzi Ninoa and TH strains from Oaxaca State, México

Bioorganic & medicinal chemistry, 2021-10, Vol.48, p.116417-116417, Article 116417

2021

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Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2

Bioorganic & medicinal chemistry, 2021-09, Vol.46, p.116364-116364, Article 116364

2021

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Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome

Bioorganic & medicinal chemistry, 2021-05, Vol.38, p.116138, Article 116138

2021

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Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents

Bioorganic & medicinal chemistry, 2020-07, Vol.28 (13), p.115574, Article 115574

2020

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Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

Bioorganic & medicinal chemistry, 2020-07, Vol.28 (13), p.115530-115530, Article 115530

2020

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Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir – resistant herpes simplex virus 1 infection

Bioorganic & medicinal chemistry, 2020-02, Vol.28 (4), p.115304, Article 115304

2020

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Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria

Bioorganic & medicinal chemistry, 2020-02, Vol.28 (3), p.115282-115282, Article 115282

Chbib, Christiane

2020

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Superior inhibition of influenza virus hemagglutinin-mediated fusion by indole-substituted spirothiazolidinones

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115130, Article 115130

2020

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Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115185, Article 115185

2020

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Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115213, Article 115213

2020

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Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The ‘fluorine-walk’ analysis

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115187, Article 115187

2020

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Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115232-115232, Article 115232

2020

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Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity

Bioorganic & medicinal chemistry, 2019-05, Vol.27 (10), p.2052-2065

2019

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Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria

Bioorganic & medicinal chemistry, 2019-05, Vol.27 (9), p.1776-1788

2019

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Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors

Bioorganic & medicinal chemistry, 2019-05, Vol.27 (9), p.1804-1817

2019

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Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus

Bioorganic & medicinal chemistry, 2019-05, Vol.27 (9), p.1845-1854

2019

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Optimization of benzenesulfonyl derivatives as anti-Trypanosomatidae agents: Structural design, synthesis, and pharmacological assessment against Trypanosoma cruzi and Leishmania infantum

Design, synthesis, evaluation and optimization of novel azole analogues as potent antifungal agents

Novel xanthone antibacterials: Semi-synthesis, biological evaluation, and the action mechanisms

Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors

Synthesis and evaluation of enantiomers of hydroxychloroquine against SARS-CoV-2 in vitro

Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors

Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies

Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents

Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors

In vitro, ex vivo and in vivo short-term screening of DHEA nitrate derivatives activity over Trypanosoma cruzi Ninoa and TH strains from Oaxaca State, México

Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2

Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome

Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents

Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir – resistant herpes simplex virus 1 infection

Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria

Superior inhibition of influenza virus hemagglutinin-mediated fusion by indole-substituted spirothiazolidinones

Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives

Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology

Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The ‘fluorine-walk’ analysis

Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria

Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors

Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus

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