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Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.854

1999

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In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1251

2003

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Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

The Journal of pharmacology and experimental therapeutics, 1999-02, Vol.288 (2), p.791

1999

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Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro

The Journal of pharmacology and experimental therapeutics, 1997-09, Vol.282 (3), p.1465

1997

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Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes

The Journal of pharmacology and experimental therapeutics, 1998-04, Vol.285 (1), p.127

1998

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Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat

The Journal of pharmacology and experimental therapeutics, 1993-01, Vol.264 (1), p.438

1993

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Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P4502E1 in rat kidney

The Journal of pharmacology and experimental therapeutics, 1994-07, Vol.270 (1), p.407

1994

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Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat

The Journal of pharmacology and experimental therapeutics, 1994-07, Vol.270 (1), p.348

1994

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Phencyclidine continuous dosing produces a treatment time-dependent regulation of rat CYP2C11 function, protein expression and mRNA levels

The Journal of pharmacology and experimental therapeutics, 1997-04, Vol.281 (1), p.574

1997

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Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases

The Journal of pharmacology and experimental therapeutics, 1993-11, Vol.267 (2), p.758

1993

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Suppressed expression of phenobarbital-inducible hepatic cytochrome P-450s in Eisai-hyperbilirubinuria rats (EHBR/Eis)

The Journal of pharmacology and experimental therapeutics, 1996-06, Vol.277 (3), p.1676

1996

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Interleukin-1 beta differentially represses drug-metabolizing enzymes in arthritic female rats

The Journal of pharmacology and experimental therapeutics, 1993-02, Vol.264 (2), p.1012

1993

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Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

The Journal of pharmacology and experimental therapeutics, 2007-01, Vol.320 (1), p.72

2007

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Enantiomeric metabolic interactions and stereoselective human methadone metabolism

The Journal of pharmacology and experimental therapeutics, 2007-04, Vol.321 (1), p.389

2007

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20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries

The Journal of pharmacology and experimental therapeutics, 2013-07, Vol.346 (1), p.67

2013

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Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2

The Journal of pharmacology and experimental therapeutics, 2001-12, Vol.299 (3), p.874

2001

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Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.908

2009

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Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil

The Journal of pharmacology and experimental therapeutics, 2004-10, Vol.311 (1), p.228

2004

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A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states

The Journal of pharmacology and experimental therapeutics, 2013-07, Vol.346 (1), p.113

2013

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Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine

The Journal of pharmacology and experimental therapeutics, 2012-11, Vol.343 (2), p.362

2012

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Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide

The Journal of pharmacology and experimental therapeutics, 2011-11, Vol.339 (2), p.451

2011

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Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.549

2002

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Hydrocodone, Oxycodone, and Morphine Metabolism and Drug-Drug Interactions

The Journal of pharmacology and experimental therapeutics, 2023-11, Vol.387 (2), p.150

2023

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Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor

The Journal of pharmacology and experimental therapeutics, 2006-06, Vol.317 (3), p.1200

2006

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Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

The Journal of pharmacology and experimental therapeutics, 2003-01, Vol.304 (1), p.223

2003

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Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities

In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)

Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro

Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes

Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat

Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P4502E1 in rat kidney

Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat

Phencyclidine continuous dosing produces a treatment time-dependent regulation of rat CYP2C11 function, protein expression and mRNA levels

Mechanism-based inactivation of cytochrome P450 1A1 by N-aralkyl-1-aminobenzotriazoles in guinea pig kidney in vivo and in vitro: minimal effects on metabolism of arachidonic acid by renal P450-dependent monooxygenases

Suppressed expression of phenobarbital-inducible hepatic cytochrome P-450s in Eisai-hyperbilirubinuria rats (EHBR/Eis)

Interleukin-1 beta differentially represses drug-metabolizing enzymes in arthritic female rats

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

Enantiomeric metabolic interactions and stereoselective human methadone metabolism

20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries

Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2

Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil

A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states

Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine

Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide

Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

Hydrocodone, Oxycodone, and Morphine Metabolism and Drug-Drug Interactions

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

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