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Targeting CDK4 and CDK6: From Discovery to Therapy

Cancer discovery, 2016-04, Vol.6 (4), p.353-367

2016

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Overactivation of IL6 cis‑signaling in leukocytes is an inflammatory hallmark of deep vein thrombosis

Molecular medicine reports, 2022-04, Vol.25 (4), Article 136

2022

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Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis

Oncotarget, 2017-04, Vol.8 (17), p.28683-28695

2017

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hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells

International journal of oncology, 2018-11, Vol.53 (5), p.2200-2212

2018

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Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation

World journal of gastroenterology : WJG, 2017-02, Vol.23 (6), p.986-998

2017

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Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma

Oncology reports, 2020-09, Vol.44 (3), p.987-1002

2020

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DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis

Molecular medicine reports, 2020-09, Vol.22 (3), p.2273-2282

2020

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MicroRNA-146a Ameliorates Inflammation via TRAF6/NF-κB Pathway in Intervertebral Disc Cells

Medical science monitor, 2017-02, Vol.23, p.659-664

2017

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Fragment-Based Drug Design of Selective HDAC6 Inhibitors

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2266, p.155

2021

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CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Oncotarget, 2014-08, Vol.5 (15), p.6512-6525

2014

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Analysis of Expression and Functions of Histone Deacetylase 6 (HDAC6)

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1436, p.85

2016

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Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

Oncotarget, 2016-11, Vol.7 (48), p.79557-79571

2016

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Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

Oncotarget, 2017-09, Vol.8 (43), p.73745-73756

2017

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Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis

International journal of molecular medicine, 2019-02, Vol.43 (2), p.1049

2019

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CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Cancer discovery, 2018-02, Vol.8 (2), p.216-233

2018

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Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

Oncotarget, 2016-06, Vol.7 (26), p.39595-39608

2016

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Esophageal carcinoma: Towards targeted therapies

Cellular oncology (Dordrecht), 2020-04, Vol.43 (2), p.195-209

2020

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A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer

Oncotarget, 2016-09, Vol.7 (42), p.68012-68022

2016

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Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Oncotarget, 2015-06, Vol.6 (18), p.15788-15801

2015

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Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Oncotarget, 2015-10, Vol.6 (30), p.30178-30193

2015

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The effects of TRAF6 on proliferation, apoptosis and invasion in osteosarcoma are regulated by miR-124

International journal of molecular medicine, 2018-05, Vol.41 (5), p.2968-2976

2018

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Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases

Oncology reports, 2021-04, Vol.45 (4), p.1, Article 2

2021

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HDAC6: A unique HDAC family member as a cancer target

Cellular oncology (Dordrecht), 2022-10, Vol.45 (5), p.779-829

2022

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Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus Nephritis

Medical science monitor, 2017-05, Vol.23, p.2550-2557

2017

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Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice

Oncotarget, 2016-05, Vol.7 (19), p.27527-27537

2016

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Targeting CDK4 and CDK6: From Discovery to Therapy

Overactivation of IL6 cis‑signaling in leukocytes is an inflammatory hallmark of deep vein thrombosis

Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis

hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells

Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation

Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma

DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis

MicroRNA-146a Ameliorates Inflammation via TRAF6/NF-κB Pathway in Intervertebral Disc Cells

Fragment-Based Drug Design of Selective HDAC6 Inhibitors

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Analysis of Expression and Functions of Histone Deacetylase 6 (HDAC6)

Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity

Reciprocal expression of INSM1 and YAP1 defines subgroups in small cell lung cancer

Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

Esophageal carcinoma: Towards targeted therapies

A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

The effects of TRAF6 on proliferation, apoptosis and invasion in osteosarcoma are regulated by miR-124

Combination of miR‑143 and miR‑506 reduces lung and pancreatic cancer cell growth through the downregulation of cyclin‑dependent kinases

HDAC6: A unique HDAC family member as a cancer target

Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus Nephritis

Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice

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