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Huntington’s Disease: Latest Frontiers in Therapeutics

Current neurology and neuroscience reports, 2024-08, Vol.24 (8), p.255-264

2024

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New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders

Synapse (New York, N.Y.), 2024-07, Vol.78 (4), p.e22301-n/a

2024

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Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease

Neurology and therapy, 2024-06, Vol.13 (3), p.655-675

2024

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Potential Use of the Cholesterol Transfer Inhibitor U18666A as a Potent Research Tool for the Study of Cholesterol Mechanisms in Neurodegenerative Disorders

Molecular neurobiology, 2024-06, Vol.61 (6), p.3503-3527

2024

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Focused Ultrasound-Mediated Disruption of the Blood–Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington’s Disease

Pharmaceutics, 2024-05, Vol.16 (6), p.710

2024

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3-Hydroxyanthranilic Acid Delays Paralysis in Caenorhabditis elegans Models of Amyloid-Beta and Polyglutamine Proteotoxicity

Biomolecules (Basel, Switzerland), 2024-05, Vol.14 (5), p.599

2024

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Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation

Autophagy, 2024-05, Vol.20 (5), p.1159-1182

2024

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Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats

Neurotoxicology (Park Forest South), 2024-05, Vol.102, p.12-28

2024

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Practical Three-Component Regioselective Synthesis of Drug-Like 3‑Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

ACS chemical neuroscience, 2024-05, Vol.15 (9), p.1828-1881

2024

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Multifunctional Nanocarriers for Alzheimer’s Disease: Befriending the Barriers

Molecular neurobiology, 2024-05, Vol.61 (5), p.3042-3089

2024

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Real-world experience with Deutetrabenazine management in patients with Huntington’s disease using video-based telemedicine

Neurological sciences, 2024-05, Vol.45 (5), p.2047-2055

2024

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Is maintenance therapy warranted for recurrent mania in a woman with a positive family history of Huntington's disease?

Bipolar disorders, 2024-05, Vol.26 (3), p.300-302

2024

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The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ

EBioMedicine, 2024-05, Vol.103, p.105124, Article 105124

2024

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Activation of alpha-7 nicotinic acetylcholine receptor by tropisetron mitigates 3-nitropropionic acid-induced Huntington's disease in rats: Role of PI3K/Akt and JAK2/NF-κB signaling pathways

Chemico-biological interactions, 2024-04, Vol.393, p.110957-110957, Article 110957

2024

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Microglial cytokines poison neuronal autophagy via CCR5, a druggable target

Autophagy, 2024-04, Vol.20 (4), p.949-951

2024

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Optogenetics in chronic neurodegenerative diseases, controlling the brain with light: A systematic review

Journal of neuroscience research, 2024-04, Vol.102 (4), p.e25321-n/a

2024

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Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventions

Chemical biology & drug design, 2024-04, Vol.103 (4), p.e14515-e14515

2024

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Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice

Experimental neurology, 2024-04, Vol.374, p.114675-114675, Article 114675

2024

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Orphan GPR52 as an emerging neurotherapeutic target

Drug discovery today, 2024-04, Vol.29 (4), p.103922-103922, Article 103922

2024

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Neuroinflammation in Neurodegenerative Disorders: Current Knowledge and Therapeutic Implications

International journal of molecular sciences, 2024-04, Vol.25 (7), p.3995

2024

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Glycine transporter-1 inhibition by NFPS promotes neuroprotection against striatal damage models

Neuroscience letters, 2024-03, Vol.826, p.137715-137715, Article 137715

2024

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Lowering mutant huntingtin by small molecules relieves Huntington’s disease symptoms and progression

EMBO molecular medicine, 2024-03, Vol.16 (3), p.523-546

2024

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Levothyroxine attenuates behavioral impairment and improves oxidative stress and histological alteration 3-nitropropionic acid induced experimental Huntington's disease in rats

Behavioural brain research, 2024-03, Vol.461, p.114864-114864, Article 114864

2024

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Emerging antibody-based therapies for Huntington's disease: current status and perspectives for future development

Expert review of neurotherapeutics, 2024-03, Vol.24 (3), p.299-312

2024

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Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target

Biomedicine & pharmacotherapy, 2024-03, Vol.172, p.116204-116204, Article 116204

2024

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