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Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

Proceedings of the National Academy of Sciences - PNAS, 2018-02, Vol.115 (7), p.E1618-E1626

2018

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TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (38), p.E5655-E5664

2016

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Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease

Proceedings of the National Academy of Sciences - PNAS, 2024-09, Vol.121 (39), p.e2406308121

2024

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Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (10), p.e2114303119-e2114303119

2022

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HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (1), p.E56-E64

2015

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Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington’s disease

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (49), p.24840-24851

2019

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N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (30), p.E7081-E7090

2018

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HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (40), p.15564-15569

2008

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Pharmacological Promotion of Inclusion Formation: A Therapeutic Approach for Huntington's and Parkinson's Diseases

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (11), p.4246-4251

2006

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Genome-Wide Expression Profiling of Human Blood Reveals Biomarkers for Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (31), p.11023-11028

2005

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ESET/SETDB1 Gene Expression and Histone H3 (K9) Trimethylation in Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (50), p.19176-19181

2006

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Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14078-14083

2015

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Minocycline Inhibits Caspase-Independent and -Dependent Mitochondrial Cell Death Pathways in Models of Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2003-09, Vol.100 (18), p.10483-10487

2003

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A Small-Molecule Therapeutic Lead for Huntington's Disease: Preclinical Pharmacology and Efficacy of C2-8 in the R6/2 Transgenic Mouse

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (42), p.16685-16689

2007

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Tauroursodeoxycholic Acid, A Bile Acid, is Neuroprotective in a Transgenic Animal Model of Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10671-10676

2002

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Identification of Combinatorial Drug Regimens for Treatment of Huntington's Disease Using Drosophila

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (10), p.3777-3781

2005

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Identification of Benzothiazoles as Potential Polyglutamine Aggregation Inhibitors of Huntington's Disease by Using an Automated Filter Retardation Assay

Proceedings of the National Academy of Sciences - PNAS, 2002-12, Vol.99 (suppl_4), p.16400-16406

2002

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Inhibitors of metabolism rescue cell death in Huntington's disease models

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (36), p.14525-14530

2007

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Ciliary Neurotrophic Factor Protects Striatal Output Neurons in an Animal Model of Huntington Disease

Proceedings of the National Academy of Sciences - PNAS, 1996-07, Vol.93 (14), p.7346-7351

1996

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Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

Proceedings of the National Academy of Sciences - PNAS, 2018-09, Vol.115 (37), p.E8765-E8774

2018

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Therapeutic Silencing of Mutant Huntingtin with siRNA Attenuates Striatal and Cortical Neuropathology and Behavioral Deficits

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (43), p.17204-17209

2007

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

Proceedings of the National Academy of Sciences - PNAS, 2008-04, Vol.105 (15), p.5868-5873

2008

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Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse

Proceedings of the National Academy of Sciences - PNAS, 2011-10, Vol.108 (41), p.17141-17146

2011

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Clioquinol Down-Regulates Mutant Huntingtin Expression in vitro and Mitigates Pathology in a Huntington's Disease Mouse Model

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (33), p.11840-11845

2005

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FGF-2 Promotes Neurogenesis and Neuroprotection and Prolongs Survival in a Transgenic Mouse Model of Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (50), p.18189-18194

2005

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Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington’s disease

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

Pharmacological Promotion of Inclusion Formation: A Therapeutic Approach for Huntington's and Parkinson's Diseases

Genome-Wide Expression Profiling of Human Blood Reveals Biomarkers for Huntington's Disease

ESET/SETDB1 Gene Expression and Histone H3 (K9) Trimethylation in Huntington's Disease

Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Minocycline Inhibits Caspase-Independent and -Dependent Mitochondrial Cell Death Pathways in Models of Huntington's Disease

A Small-Molecule Therapeutic Lead for Huntington's Disease: Preclinical Pharmacology and Efficacy of C2-8 in the R6/2 Transgenic Mouse

Tauroursodeoxycholic Acid, A Bile Acid, is Neuroprotective in a Transgenic Animal Model of Huntington's Disease

Identification of Combinatorial Drug Regimens for Treatment of Huntington's Disease Using Drosophila

Identification of Benzothiazoles as Potential Polyglutamine Aggregation Inhibitors of Huntington's Disease by Using an Automated Filter Retardation Assay

Inhibitors of metabolism rescue cell death in Huntington's disease models

Ciliary Neurotrophic Factor Protects Striatal Output Neurons in an Animal Model of Huntington Disease

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

Therapeutic Silencing of Mutant Huntingtin with siRNA Attenuates Striatal and Cortical Neuropathology and Behavioral Deficits

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi

Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse

Clioquinol Down-Regulates Mutant Huntingtin Expression in vitro and Mitigates Pathology in a Huntington's Disease Mouse Model

FGF-2 Promotes Neurogenesis and Neuroprotection and Prolongs Survival in a Transgenic Mouse Model of Huntington's Disease

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