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Structural insights into G-protein-coupled receptor allostery

Nature (London), 2018-07, Vol.559 (7712), p.45-53

2018

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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Nature (London), 2017-06, Vol.546 (7656), p.118-123

2017

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Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

PLoS biology, 2021-06, Vol.19 (6), p.e3001295

2021

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Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Cell, 2017-02, Vol.168 (5), p.867-877.e13

2017

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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Nature (London), 2016-03, Vol.531 (7594), p.335-340

2016

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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Nature (London), 2018-03, Vol.555 (7694), p.121-125

2018

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Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges

Neuropharmacology, 2024-11, Vol.258, p.110092, Article 110092

2024

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Structural insights into the human P2X1 receptor and ligand interactions

Nature communications, 2024-09, Vol.15 (1), p.8418-14, Article 8418

2024

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Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Nature (London), 2018-06, Vol.558 (7711), p.559-563

2018

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Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

The Journal of general physiology, 2018-10, Vol.150 (10), p.1360-1372

2018

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Recent advances in the determination of G protein-coupled receptor structures

Current opinion in structural biology, 2018-08, Vol.51, p.28-34

2018

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Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Nature (London), 2021-09, Vol.597 (7877), p.571-576

2021

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Discovery of 2-Methyl-5-(1 H -pyrazol-4-yl)pyridines and Related Heterocycles as Promising M 4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Journal of medicinal chemistry, 2024-08, Vol.67 (15), p.13286-13304

2024

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The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors

Current opinion in structural biology, 2023-04, Vol.79, p.102560-102560, Article 102560

2023

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Importance of receptor expression in the classification of novel ligands at the M 2 muscarinic acetylcholine receptor

British journal of pharmacology, 2024-07, Vol.181 (14), p.2338-2350

2024

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Selective G protein signaling driven by substance P-neurokinin receptor dynamics

Nature chemical biology, 2022-01, Vol.18 (1), p.109-115

2022

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Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor

British journal of pharmacology, 2024-07, Vol.181 (14), p.2338-2350

2024

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Role of Conserved Tyrosine Lid Residues in the Activation of the M 2 Muscarinic Acetylcholine Receptor

Molecular pharmacology, 2023-09, Vol.104 (3), p.92-104

2023

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The Design, Synthesis, and Evaluation of Novel 9‑Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.12367-12385

2022

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Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors

Molecular pharmacology, 2011-08, Vol.80 (2), p.294-303

2011

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Structural basis of efficacy-driven ligand selectivity at GPCRs

Nature chemical biology, 2023-07, Vol.19 (7), p.805-814

2023

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Discovery of 2‑Methyl-5-(1H‑pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Journal of medicinal chemistry, 2024-08, Vol.67 (15), p.13286-13304

2024

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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

Nature communications, 2023-09, Vol.14 (1), p.5440-11, Article 5440

2023

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Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor

Molecular pharmacology, 2023-09, Vol.104 (3), p.92-104

2023

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Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

ACS chemical biology, 2012-11, Vol.7 (11), p.1830-1839

2012

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Structural insights into G-protein-coupled receptor allostery

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges

Structural insights into the human P2X1 receptor and ligand interactions

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

Recent advances in the determination of G protein-coupled receptor structures

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Discovery of 2-Methyl-5-(1 H -pyrazol-4-yl)pyridines and Related Heterocycles as Promising M 4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors

Importance of receptor expression in the classification of novel ligands at the M 2 muscarinic acetylcholine receptor

Selective G protein signaling driven by substance P-neurokinin receptor dynamics

Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor

Role of Conserved Tyrosine Lid Residues in the Activation of the M 2 Muscarinic Acetylcholine Receptor

The Design, Synthesis, and Evaluation of Novel 9‑Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors

Structural basis of efficacy-driven ligand selectivity at GPCRs

Discovery of 2‑Methyl-5-(1H‑pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

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