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Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S]

Journal of lipid research, 2016-12, Vol.57 (12), p.2130-2137

2016

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Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy

Clinical cancer research, 2018-05, Vol.24 (9), p.2138-2147

2018

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Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling

British journal of cancer, 2021-11, Vol.125 (11), p.1552-1560

2021

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Aryl hydrocarbon receptor is required for optimal B‐cell proliferation

The EMBO journal, 2017-01, Vol.36 (1), p.116-128

2017

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Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

British journal of cancer, 2016-12, Vol.115 (12), p.1530-1539

2016

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Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Proceedings of the National Academy of Sciences - PNAS, 2007-12, Vol.104 (49), p.19589-19594

2007

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Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

Toxicological sciences, 2014-08, Vol.140 (2), p.259-270

2014

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Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents

Cancer research (Chicago, Ill.), 2006-11, Vol.66 (22), p.10983-10994

2006

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In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents

Cancer research (Chicago, Ill.), 2014-08, Vol.74 (16), p.4378-4387

2014

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Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes

Molecular pharmacology, 2019-01, Vol.95 (1), p.97-105

2019

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NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

Drug metabolism and disposition, 2013-01, Vol.41 (1), p.12-23

2013

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Generation and utility of genetically humanized mouse models

Drug discovery today, 2013-12, Vol.18 (23-24), p.1200-1211

2013

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A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

The Journal of clinical investigation, 2008-09, Vol.118 (9), p.3228-3239

2008

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Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

The Journal of physiology, 2018-01, Vol.596 (1), p.105-127

2018

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HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

PloS one, 2014-11, Vol.9 (11), p.e114055

2014

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Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism [version 2; peer review: 2 approved]

F1000 research, 2022-01, Vol.11, p.1081-1081

2022

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Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies [version 1; peer review: 2 approved]

F1000 research, 2022, Vol.11, p.1164

2022

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Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models

Cancer research (Chicago, Ill.), 2015-11, Vol.75 (21), p.4573-4581

2015

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Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line

Molecular pharmacology, 2011-09, Vol.80 (3), p.518-528

2011

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Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines

Molecular pharmacology, 2012-01, Vol.81 (1), p.63-72

2012

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Xenobiotic receptor humanized mice and their utility

Drug metabolism reviews, 2013-02, Vol.45 (1), p.110-121

2013

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Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines

Molecular pharmacology, 2012-12, Vol.82 (6), p.1022-1029

2012

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Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

Molecular neurobiology, 2012-06, Vol.45 (3), p.466-477

2012

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Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

PloS one, 2018-02, Vol.13 (2), p.e0192223-e0192223

2018

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Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

Toxicology (Amsterdam), 2014-04, Vol.318, p.1-12

2014

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Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S]

Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy

Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling

Aryl hydrocarbon receptor is required for optimal B‐cell proliferation

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents

In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents

Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes

NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology

Generation and utility of genetically humanized mouse models

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism [version 2; peer review: 2 approved]

Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies [version 1; peer review: 2 approved]

Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines

Xenobiotic receptor humanized mice and their utility

Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines

Glutathione S-Transferase pi Mediates MPTP-Induced c-Jun N-Terminal Kinase Activation in the Nigrostriatal Pathway

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions

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