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Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling

Journal of lipid research, 2022-06, Vol.63 (6), p.100225-100225, Article 100225

2022

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Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes

The Journal of experimental medicine, 2019-07, Vol.216 (7), p.1582-1598

2019

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SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis

The FASEB journal, 2023-05, Vol.37 (5), p.e22919-n/a

2023

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CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (13), p.E1614-E1623

2015

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Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis

Journal of lipid research, 2023-12, Vol.64 (12), p.100463-100463, Article 100463

2023

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Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration

The Journal of biological chemistry, 2004-04, Vol.279 (15), p.15396-15401

2004

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In Memoriam: Roscoe Owen Brady (1923–2016)

Journal of lipid research, 2016-10, Vol.57 (10), p.1749-1750

2016

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Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis

eLife, 2022-10, Vol.11

2022

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Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis

Molecular genetics and metabolism reports, 2019-12, Vol.21, p.100513-100513, Article 100513

2019

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Autophagy regulates sphingolipid levels in the liver[S]

Journal of lipid research, 2014-12, Vol.55 (12), p.2521-2531

2014

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S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells

International journal of molecular sciences, 2018-04, Vol.19 (5), p.1279

2018

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Deletion of Macrophage-Inflammatory Protein 1α Retards Neurodegeneration in Sandhoff Disease Mice

Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (22), p.8425-8430

2004

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Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

Molecular metabolism (Germany), 2024-01, Vol.79, p.101851-101851, Article 101851

2024

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Deafness and Stria Vascularis Defects in S1P2 Receptor-null Mice

The Journal of biological chemistry, 2007-04, Vol.282 (14), p.10690-10696

2007

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Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

Frontiers in molecular neuroscience, 2017-10, Vol.10, p.317-317

2017

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The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina Light Responses

Biomolecules (Basel, Switzerland), 2023-11, Vol.13 (12), p.1691

2023

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Subcellular Origin of Sphingosine 1-Phosphate Is Essential for Its Toxic Effect in Lyase-deficient Neurons

The Journal of biological chemistry, 2009-04, Vol.284 (17), p.11346-11353

2009

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The Complement Regulator Susd4 Influences Nervous-System Function and Neuronal Morphology in Mice

iScience, 2020-03, Vol.23 (3), p.100957-100957, Article 100957

2020

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HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation

Science signaling, 2015-08, Vol.8 (389), p.ra79

2015

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Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development

The Journal of clinical investigation, 2014-11, Vol.124 (11), p.4823-4828

2014

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Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Cells (Basel, Switzerland), 2022-09, Vol.11 (18), p.2914

2022

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Essential Requirement for Sphingosine Kinase 2 in a Sphingolipid Apoptosis Pathway Activated by FTY720 Analogues

The Journal of biological chemistry, 2007-05, Vol.282 (21), p.15833-15842

2007

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Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo

Frontiers in cellular neuroscience, 2016-11, Vol.10, p.258-258

2016

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The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR

Nature immunology, 2009-07, Vol.10 (7), p.769-777

2009

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Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice

International journal of biological sciences, 2007-01, Vol.3 (2), p.120-128

2007

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Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling

Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes

SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis

Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration

In Memoriam: Roscoe Owen Brady (1923–2016)

Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis

Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis

Autophagy regulates sphingolipid levels in the liver[S]

S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells

Deletion of Macrophage-Inflammatory Protein 1α Retards Neurodegeneration in Sandhoff Disease Mice

Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

Deafness and Stria Vascularis Defects in S1P2 Receptor-null Mice

Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina Light Responses

Subcellular Origin of Sphingosine 1-Phosphate Is Essential for Its Toxic Effect in Lyase-deficient Neurons

The Complement Regulator Susd4 Influences Nervous-System Function and Neuronal Morphology in Mice

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation

Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Essential Requirement for Sphingosine Kinase 2 in a Sphingolipid Apoptosis Pathway Activated by FTY720 Analogues

Ablation of Sphingosine 1-Phosphate Receptor Subtype 3 Impairs Hippocampal Neuron Excitability In vitro and Spatial Working Memory In vivo

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR

Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice

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