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Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7591

2020

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Regulation of platelet membrane protein shedding in health and disease

Platelets (Edinburgh), 2017-05, Vol.28 (4), p.342-353

2017

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Platelet intrinsic apoptosis

Thrombosis research, 2023-11, Vol.231, p.206-213

Josefsson, Emma C.

2023

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The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Cell death & disease, 2021-01, Vol.12 (1), p.133-133, Article 133

2021

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Regulation of platelet lifespan by apoptosis

Platelets (Edinburgh), 2016-09, Vol.27 (6), p.497-504

2016

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Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (7), p.2599-2604

2013

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A model for studying the hemostatic consumption or destruction of platelets

PloS one, 2013-03, Vol.8 (3), p.e57783-e57783

2013

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Membrane budding is a major mechanism of in vivo platelet biogenesis

The Journal of experimental medicine, 2020-09, Vol.217 (9)

2020

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Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice

Blood, 2012-02, Vol.119 (5), p.1263-1273

2012

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Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Science translational medicine, 2017-09, Vol.9 (409)

2017

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Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Blood, 2011-08, Vol.118 (6), p.1663-1674

2011

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Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation

Blood, 2022-04, Vol.139 (17), p.2673-2690

2022

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Platelets disrupt vasculogenic mimicry by cancer cells

Scientific reports, 2020-04, Vol.10 (1), p.5869-5869, Article 5869

2020

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The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production

Blood, 2022-03, Vol.139 (9), p.1359-1373

2022

Volltextzugriff (PDF)

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor–induced thrombocytopenia

Blood, 2011-03, Vol.117 (13), p.3658-3668

2011

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Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

The Journal of experimental medicine, 2011-09, Vol.208 (10), p.2017-2031

2011

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Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes

Arteriosclerosis, thrombosis, and vascular biology, 2021-03, Vol.41 (3), p.1167

2021

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The origin and function of platelet glycosyltransferases

Blood, 2012-07, Vol.120 (3), p.626-635

2012

Volltextzugriff (PDF)

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Blood, 2018-07, Vol.132 (2), p.197-209

2018

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Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Blood, 2012-05, Vol.119 (18), p.4283-4290

2012

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Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL

Blood, 2015-08, Vol.126 (6), p.807-816

2015

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Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma

Oncogene, 2020-07, Vol.39 (29), p.5177-5186

2020

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Undercover Agents: Targeting Tumours with Modified Platelets

Trends in cancer, 2017-03, Vol.3 (3), p.235-246

2017

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Platelet senescence is regulated by an internal timer, not damage inflicted by hits

Blood, 2010-09, Vol.116 (10), p.1776-1778

2010

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Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

Regulation of platelet membrane protein shedding in health and disease

Platelet intrinsic apoptosis

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Regulation of platelet lifespan by apoptosis

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

A model for studying the hemostatic consumption or destruction of platelets

Membrane budding is a major mechanism of in vivo platelet biogenesis

Consensus report on markers to distinguish procoagulant platelets from apoptotic platelets: communication from the Scientific and Standardization Committee of the ISTH

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation

Platelets disrupt vasculogenic mimicry by cancer cells

The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor–induced thrombocytopenia

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes

The origin and function of platelet glycosyltransferases

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma

Undercover Agents: Targeting Tumours with Modified Platelets

Platelet senescence is regulated by an internal timer, not damage inflicted by hits

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