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Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

Frontiers in pharmacology, 2019-07, Vol.10, p.749-749

2019

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Metabolism and disposition of dasatinib after oral administration to humans

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1357-1364

2008

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Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.219-226

2012

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Lacteal secretion, fetal and maternal tissue distribution of dasatinib in rats

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2564-2570

2008

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In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1658-1667

2011

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Physiologically‐based pharmacokinetic modelling of a CYP2C19 substrate, BMS‐823778, utilizing pharmacogenetic data

British journal of clinical pharmacology, 2018-06, Vol.84 (6), p.1335-1345

2018

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Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1341-1356

2008

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Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.617-623

2016

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Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro

Drug metabolism and disposition, 2016-03, Vol.44 (3), p.320-328

2016

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Quantitative Analysis of Polyethylene Glycol (PEG) and PEGylated Proteins in Animal Tissues by LC-MS/MS Coupled with In-Source CID

Analytical chemistry (Washington), 2014-08, Vol.86 (15), p.7642-7649

2014

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Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans

Xenobiotica, 2016-01, Vol.46 (1), p.52-64

2016

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Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human

Drug metabolism and disposition, 2012-07, Vol.40 (7), p.1345-1356

2012

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Metabolism of [14C]gemopatrilat after oral administration to rats, dogs, and humans

Drug metabolism and disposition, 2006-06, Vol.34 (6), p.961-970

2006

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In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1093-1103

2012

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Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology

Drug metabolism and disposition, 2012-12, Vol.40 (12), p.2374-2380

2012

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Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans

Drug metabolism and disposition, 2011-05, Vol.39 (5), p.891-903

2011

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Comparative biotransformation of radiolabeled [(14)C]omapatrilat and stable-labeled [(13)C(2)]omapatrilat after oral administration to rats, dogs, and humans

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.67-75

2003

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Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans

Drug metabolism and disposition, 2010-11, Vol.38 (11), p.2049-2059

2010

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Metabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats

Xenobiotica, 2011-04, Vol.41 (4), p.312-319

2011

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Metabolism of [(14)C]omapatrilat, a sulfhydryl-containing vasopeptidase inhibitor in humans

Drug metabolism and disposition, 2001-01, Vol.29 (1), p.60

2001

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Mechanistic Studies on a P450-Mediated Rearrangement of BMS-690514: Conversion of a Pyrrolotriazine to a Hydroxypyridotriazine

Chemical research in toxicology, 2011-01, Vol.24 (1), p.125-134

2011

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Disposition of [1'-(14)C]stavudine after oral administration to humans

Drug metabolism and disposition, 2010-04, Vol.38 (4), p.655-666

2010

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Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs

Drug metabolism and disposition, 2010-07, Vol.38 (7), p.1189-1201

2010

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Acivicin-induced alterations in renal and hepatic glutathione concentrations and in γ-glutamyltransferase activities

Biochemical pharmacology, 2004-04, Vol.67 (7), p.1421-1426

2004

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Cysteine conjugate β-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in Human subjects anesthetized with Sevoflurane and in rats given compound A

Anesthesiology (Philadelphia), 1998-03, Vol.88 (3), p.611-618

1998

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Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

Metabolism and disposition of dasatinib after oral administration to humans

Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib

Lacteal secretion, fetal and maternal tissue distribution of dasatinib in rats

In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor

Physiologically‐based pharmacokinetic modelling of a CYP2C19 substrate, BMS‐823778, utilizing pharmacogenetic data

Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys

Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro

Quantitative Analysis of Polyethylene Glycol (PEG) and PEGylated Proteins in Animal Tissues by LC-MS/MS Coupled with In-Source CID

Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans

Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human

Metabolism of [14C]gemopatrilat after oral administration to rats, dogs, and humans

In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist

Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology

Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans

Comparative biotransformation of radiolabeled [(14)C]omapatrilat and stable-labeled [(13)C(2)]omapatrilat after oral administration to rats, dogs, and humans

Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans

Metabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats

Metabolism of [(14)C]omapatrilat, a sulfhydryl-containing vasopeptidase inhibitor in humans

Mechanistic Studies on a P450-Mediated Rearrangement of BMS-690514: Conversion of a Pyrrolotriazine to a Hydroxypyridotriazine

Disposition of [1'-(14)C]stavudine after oral administration to humans

Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs

Acivicin-induced alterations in renal and hepatic glutathione concentrations and in γ-glutamyltransferase activities

Cysteine conjugate β-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in Human subjects anesthetized with Sevoflurane and in rats given compound A

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