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Muscarinic receptors in the bladder: from basic research to therapeutics

British journal of pharmacology, 2006-02, Vol.147 (S2), p.S80-S87

Hegde, Sharath S.

2006

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Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against Gram-Positive Bacteria, in a Neutropenic Murine Thigh Model

Antimicrobial Agents and Chemotherapy, 2012-03, Vol.56 (3), p.1578-1583

2012

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Pharmacodynamics of Telavancin (TD-6424), a Novel Bactericidal Agent, against Gram-Positive Bacteria

Antimicrobial Agents and Chemotherapy, 2004-08, Vol.48 (8), p.3043-3050

2004

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Efficacy of Telavancin (TD-6424), a Rapidly Bactericidal Lipoglycopeptide with Multiple Mechanisms of Action, in a Murine Model of Pneumonia Induced by Methicillin-Resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4344-4346

2005

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Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite

Drug metabolism and disposition, 2020-12, Vol.48 (12), p.1312-1320

2020

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Are blood vessels a target to treat lower urinary tract dysfunction?

Naunyn-Schmiedeberg's archives of pharmacology, 2015-07, Vol.388 (7), p.687-694

2015

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Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers

Journal of antibiotics, 2008-10, Vol.61 (10), p.603-614

2008

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A Multivalent Approach to Drug Discovery for Novel Antibiotics

Journal of antibiotics, 2008-10, Vol.61 (10), p.595-602

2008

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Discovery of (R)‑1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β2 Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2609-2622

2015

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Efficacy of telavancin, a lipoglycopeptide antibiotic, in experimental models of Gram-positive infection

Expert review of anti-infective therapy, 2014-12, Vol.12 (12), p.1463-1475

2014

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Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation in the Rat

Journal of cardiovascular pharmacology, 2011-04, Vol.57 (4), p.495-504

2011

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Discovery of TD-0212, an Orally Active Dual Pharmacology AT 1 Antagonist and Neprilysin Inhibitor (ARNI)

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.86-91

2019

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Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

The Journal of pharmacology and experimental therapeutics, 2014-10, Vol.351 (1), p.190

2014

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Pharmacological properties of revefenacin (TD‐4208), a novel, nebulized long‐acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues

Pharmacology research & perspectives, 2018-06, Vol.6 (3), p.e00400-n/a

2018

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Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI)

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.86-91

2019

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Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus

Journal of antimicrobial chemotherapy, 2006-08, Vol.58 (2), p.462-465

2006

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Efficacy of telavancin in a murine model of pneumonia induced by methicillin-susceptible Staphylococcus aureus

Journal of antimicrobial chemotherapy, 2008-01, Vol.61 (1), p.169-172

2008

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Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO‐K1 cells

British journal of pharmacology, 1999-05, Vol.127 (2), p.590-596

1999

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A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.939-943

2013

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Activity of telavancin against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) in vitro and in an in vivo mouse model of bacteraemia

Journal of antimicrobial chemotherapy, 2010-04, Vol.65 (4), p.725-728

2010

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Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β2 -adrenoceptor agonist (MABA)

Pulmonary pharmacology & therapeutics, 2012-10, Vol.25 (5), p.357-363

2012

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The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity

Naunyn-Schmiedeberg's archives of pharmacology, 2013-06, Vol.386 (6), p.471-478

2013

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Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

Pulmonary pharmacology & therapeutics, 2012-10, Vol.25 (5), p.357-363

2012

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Efficacy of telavancin against glycopeptide-intermediate Staphylococcus aureus in the neutropenic mouse bacteraemia model

Journal of antimicrobial chemotherapy, 2009-04, Vol.63 (4), p.763-766

2009

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Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?

Naunyn-Schmiedeberg's archives of pharmacology, 2006-11, Vol.374 (2), p.79-85

2006

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Muscarinic receptors in the bladder: from basic research to therapeutics

Pharmacodynamics of TD-1792, a Novel Glycopeptide-Cephalosporin Heterodimer Antibiotic Used against Gram-Positive Bacteria, in a Neutropenic Murine Thigh Model

Pharmacodynamics of Telavancin (TD-6424), a Novel Bactericidal Agent, against Gram-Positive Bacteria

Efficacy of Telavancin (TD-6424), a Rapidly Bactericidal Lipoglycopeptide with Multiple Mechanisms of Action, in a Murine Model of Pneumonia Induced by Methicillin-Resistant Staphylococcus aureus

Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite

Are blood vessels a target to treat lower urinary tract dysfunction?

Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers

A Multivalent Approach to Drug Discovery for Novel Antibiotics

Efficacy of telavancin, a lipoglycopeptide antibiotic, in experimental models of Gram-positive infection

Concomitant Angiotensin AT1 Receptor Antagonism and Neprilysin Inhibition Produces Omapatrilat-like Antihypertensive Effects Without Promoting Tracheal Plasma Extravasation in the Rat

Discovery of TD-0212, an Orally Active Dual Pharmacology AT 1 Antagonist and Neprilysin Inhibitor (ARNI)

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

Pharmacological properties of revefenacin (TD‐4208), a novel, nebulized long‐acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissues

Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI)

Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus

Efficacy of telavancin in a murine model of pneumonia induced by methicillin-susceptible Staphylococcus aureus

Comparative pharmacology of recombinant human M3 and M5 muscarinic receptors expressed in CHO‐K1 cells

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

Activity of telavancin against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) in vitro and in an in vivo mouse model of bacteraemia

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β2 -adrenoceptor agonist (MABA)

The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

Efficacy of telavancin against glycopeptide-intermediate Staphylococcus aureus in the neutropenic mouse bacteraemia model

Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?

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