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Two Approaches to Discovering and Developing New Drugs for Chagas Disease

Memórias do Instituto Oswaldo Cruz, 2009-07, Vol.104 (s1), p.263-269

2009

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Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity

Biochimica et biophysica acta. Proteins and proteomics, 2021-02, Vol.1869 (2), p.140562-140562, Article 140562

2021

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Engineering of a macromolecular scaffold to develop specific protease inhibitors

Nature biotechnology, 2003-09, Vol.21 (9), p.1063-1068

2003

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Structural determinants of specificity in the cysteine protease cruzain

Protein science, 1997-08, Vol.6 (8), p.1603-1611

1997

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Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions

The Journal of biological chemistry, 1993-06, Vol.268 (16), p.11939-11945

1993

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Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi

The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6115-6118

1993

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The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase

Biochemical journal, 2004-04, Vol.379 (Pt 1), p.107-118

2004

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Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related

The Journal of biological chemistry, 1990-03, Vol.265 (9), p.5113-5120

1990

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The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites

The Journal of biological chemistry, 1994-07, Vol.269 (30), p.19565-19572

1994

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Trypsin specificity increased through substrate-assisted catalysis

Biochemistry (Easton), 1995-09, Vol.34 (36), p.11521-11527

1995

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Cercarial Elastase Is Encoded by a Functionally Conserved Gene Family across Multiple Species of Schistosomes

The Journal of biological chemistry, 2002-07, Vol.277 (27), p.24618-24624

2002

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Papa's got a brand new tag: advances in identification of proteases and their substrates

Trends in biotechnology (Regular ed.), 2005-02, Vol.23 (2), p.59-64

2005

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Engineering Human Immunodeficiency Virus 1 Protease Heterodimers as Macromolecular Inhibitors of Viral Maturation

Proceedings of the National Academy of Sciences - PNAS, 1996-10, Vol.93 (21), p.11477-11482

1996

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A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family

The Journal of biological chemistry, 1988-11, Vol.263 (33), p.17828-17836

1988

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Relocating a Negative Charge in the Binding Pocket of Trypsin

Journal of molecular biology, 1993-04, Vol.230 (3), p.934-949

1993

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Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity

Pharmaceutical research, 1997-02, Vol.14 (2), p.176-180

1997

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Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation

Antimicrobial Agents and Chemotherapy, 1994-10, Vol.38 (10), p.2430-2439

1994

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Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI

Journal of molecular biology, 1993-04, Vol.230 (3), p.919-933

1993

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In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases

The Journal of biological chemistry, 1994-04, Vol.269 (14), p.10691-10698

1994

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

Nature structural & molecular biology, 2000-09, Vol.7 (9), p.762-765

2000

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Isolation and sequence of a rat chymotrypsin B gene

The Journal of biological chemistry, 1984-11, Vol.259 (22), p.14265-14270

1984

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Domain Flexibility in Retroviral Proteases: Structural Implications for Drug Resistant Mutations

Biochemistry (Easton), 1998-02, Vol.37 (8), p.2607-2621

1998

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Introduction of a cysteine protease active site into trypsin

Biochemistry (Easton), 1989-11, Vol.28 (24), p.9256-9263

1989

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Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site

The Journal of biological chemistry, 2003-09, Vol.278 (36), p.34517-34524

2003

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Structure of two related rat pancreatic trypsin genes

The Journal of biological chemistry, 1984-11, Vol.259 (22), p.14255-14264

1984

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Two Approaches to Discovering and Developing New Drugs for Chagas Disease

Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity

Engineering of a macromolecular scaffold to develop specific protease inhibitors

Structural determinants of specificity in the cysteine protease cruzain

Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions

Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi

The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase

Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related

The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites

Trypsin specificity increased through substrate-assisted catalysis

Cercarial Elastase Is Encoded by a Functionally Conserved Gene Family across Multiple Species of Schistosomes

Papa's got a brand new tag: advances in identification of proteases and their substrates

Engineering Human Immunodeficiency Virus 1 Protease Heterodimers as Macromolecular Inhibitors of Viral Maturation

A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family

Relocating a Negative Charge in the Binding Pocket of Trypsin

Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity

Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation

Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI

In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases

The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

Isolation and sequence of a rat chymotrypsin B gene

Domain Flexibility in Retroviral Proteases: Structural Implications for Drug Resistant Mutations

Introduction of a cysteine protease active site into trypsin

Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site

Structure of two related rat pancreatic trypsin genes

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