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Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

Pharmaceutical research, 1997-12, Vol.14 (12), p.1655-1658

1997

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Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

Gastroenterology (New York, N.Y. 1943), 1989-03, Vol.96 (3), p.736-749

1989

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The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system

Pharmaceutical research, 1996-04, Vol.13 (4), p.528-534

1996

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Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro

American Journal of Physiology: Cell Physiology, 1996-12, Vol.271 (6), p.C1973-C1980

1996

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Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

Biotechnology and bioengineering, 1995-12, Vol.48 (5), p.490-500

1995

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Optimizing oral absorption of peptides using prodrug strategies

Journal of controlled release, 1999-11, Vol.62 (1-2), p.231-238

Borchardt, Ronald T

1999

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Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway

Pharmaceutical research, 1997-02, Vol.14 (2), p.164-168

1997

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Paracellular Diffusion in Caco-2 Cell Monolayers: Effect of Perturbation on the Transport of Hydrophilic Compounds That Vary in Charge and Size

Journal of pharmaceutical sciences, 1997-10, Vol.86 (10), p.1105-1110

1997

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Orally active peptidomimetic RGD analogs that are glycoprotein IIb/IIIa antagonists

Current medicinal chemistry, 2000-04, Vol.7 (4), p.437-453

2000

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Stability of protein pharmaceuticals

Pharmaceutical research, 1989-11, Vol.6 (11), p.903-918

1989

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In vitro systems for studying intestinal drug absorption

Medicinal research reviews, 1995-03, Vol.15 (2), p.83-109

1995

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How Structural Features Influence the Biomembrane Permeability of Peptides

Journal of pharmaceutical sciences, 1996-12, Vol.85 (12), p.1336-1340

1996

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Mechanistic Roles of Neutral Surfactants on Concurrent Polarized and Passive Membrane Transport of a Model Peptide in Caco-2 Cells

Journal of pharmaceutical sciences, 1997-07, Vol.86 (7), p.813-821

1997

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Kinetics of Diketopiperazine Formation Using Model Peptides

Journal of pharmaceutical sciences, 1998-03, Vol.87 (3), p.283-288

1998

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Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes

Journal of pharmaceutical sciences, 1999-10, Vol.88 (10), p.1073-1080

1999

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VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

American journal of physiology. Heart and circulatory physiology, 2001-01, Vol.280 (1), p.H434-H440

2001

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Prodrug Strategies Based on Intramolecular Cyclization Reactions

Journal of pharmaceutical sciences, 1997-07, Vol.86 (7), p.765-767

1997

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Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain Barrier permeability of peptides

Pharmaceutical research, 1994-03, Vol.11 (3), p.412-419

1994

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The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism

The Journal of pharmacology and experimental therapeutics, 1995-04, Vol.273 (1), p.298

1995

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S-Adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy

Journal of medicinal chemistry, 1991-05, Vol.34 (5), p.1521-1530

1991

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Overexpression, Purification, and Characterization of S-Adenosylhomocysteine Hydrolase from Leishmania donovani

Archives of biochemistry and biophysics, 2000-11, Vol.383 (2), p.272-280

2000

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Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in poly(vinylpyrrolidone)

Journal of pharmaceutical sciences, 1999-10, Vol.88 (10), p.1081-1089

1999

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Chemical pathways of peptide degradation. X: Effect of metal-catalyzed oxidation on the solution structure of a histidine-containing peptide fragment of human relaxin

Pharmaceutical research, 2000-07, Vol.17 (7), p.851-858

2000

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Chemical pathways of peptide degradation : IX. Metal-catalyzed oxidation of histidine in model peptides

Pharmaceutical research, 1998-07, Vol.15 (7), p.1096-1102

1998

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The effect of β-turn structure on the passive diffusion of peptides across Caco-2 cell monolayers

Pharmaceutical research, 1997-10, Vol.14 (10), p.1332-1340

1997

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Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system

Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro

Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

Optimizing oral absorption of peptides using prodrug strategies

Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway

Paracellular Diffusion in Caco-2 Cell Monolayers: Effect of Perturbation on the Transport of Hydrophilic Compounds That Vary in Charge and Size

Orally active peptidomimetic RGD analogs that are glycoprotein IIb/IIIa antagonists

Stability of protein pharmaceuticals

In vitro systems for studying intestinal drug absorption

How Structural Features Influence the Biomembrane Permeability of Peptides

Mechanistic Roles of Neutral Surfactants on Concurrent Polarized and Passive Membrane Transport of a Model Peptide in Caco-2 Cells

Kinetics of Diketopiperazine Formation Using Model Peptides

Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes

VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

Prodrug Strategies Based on Intramolecular Cyclization Reactions

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain Barrier permeability of peptides

The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism

S-Adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy

Overexpression, Purification, and Characterization of S-Adenosylhomocysteine Hydrolase from Leishmania donovani

Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in poly(vinylpyrrolidone)

Chemical pathways of peptide degradation. X: Effect of metal-catalyzed oxidation on the solution structure of a histidine-containing peptide fragment of human relaxin

Chemical pathways of peptide degradation : IX. Metal-catalyzed oxidation of histidine in model peptides

The effect of β-turn structure on the passive diffusion of peptides across Caco-2 cell monolayers

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