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Perspective on a chemistry classification system for AI-assisted formulation development

Journal of controlled release, 2022-12, Vol.352, p.833-839

Bolger, Michael B.

2022

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Pharmaceutics, 2024-01, Vol.16 (1), p.96

2024

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Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.305-315

2019

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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Pharmaceutics, 2021-08, Vol.13 (9), p.1325

2021

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

The AAPS journal, 2021-06, Vol.23 (4), p.89-89, Article 89

2021

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A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

European journal of pharmaceutical sciences, 2020-12, Vol.155, p.105552-105552, Article 105552

2020

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The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.268-278

2019

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Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary

European journal of pharmaceutics and biopharmaceutics, 2020-10, Vol.155, p.55-68

2020

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Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations

Pharmaceutical research, 2020-12, Vol.37 (12), p.245-245, Article 245

2020

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Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

Journal of chemical education, 2020-08, Vol.97 (8), p.2212-2220

2020

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies

European journal of pharmaceutics and biopharmaceutics, 2020-11, Vol.156, p.50-63

2020

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Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

The AAPS journal, 2019-07, Vol.21 (4), p.65, Article 65

2019

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Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.821-830

2018

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Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.831-839

2018

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Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore

Bioorganic & medicinal chemistry, 2007-07, Vol.15 (14), p.4985-5002

2007

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.626-642

2017

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Applications of supercritical fluids to enhance the dissolution behaviors of Furosemide by generation of microparticles and solid dispersions

European journal of pharmaceutics and biopharmaceutics, 2012-05, Vol.81 (1), p.131-141

2012

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IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.598-609

2017

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Similar or Not? Comparison of Dissolution Profiles of Different Hydroxypropylmethyl Cellulose (HPMC) Capsules

Dissolution technologies, 2018-02, Vol.25 (1), p.6-11

2018

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Provisional Biopharmaceutical Classification of Some Common Herbs Used in Western Medicine

Molecular pharmaceutics, 2012-04, Vol.9 (4), p.815-822

2012

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In silico approach shows good predictability for free fraction in plasma and volume of distribution in human for drugs subjected to lysosomal trapping

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100899, Article 100899

2024

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Modeling of absorption

Methods in molecular biology (Clifton, N.J.), 2012, Vol.929, p.313

2012

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Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

Journal of controlled release, 1999-11, Vol.62 (1-2), p.129-140

1999

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Perspective on a chemistry classification system for AI-assisted formulation development

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary

Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations

Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies

Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension

Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series

Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability

Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Applications of supercritical fluids to enhance the dissolution behaviors of Furosemide by generation of microparticles and solid dispersions

IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Similar or Not? Comparison of Dissolution Profiles of Different Hydroxypropylmethyl Cellulose (HPMC) Capsules

Provisional Biopharmaceutical Classification of Some Common Herbs Used in Western Medicine

In silico approach shows good predictability for free fraction in plasma and volume of distribution in human for drugs subjected to lysosomal trapping

Modeling of absorption

Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

Pathway-Based Predictive Approaches for Non-Animal Assessment of Acute Inhalation Hazard Determination

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