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Duvelisib for the treatment of chronic lymphocytic leukemia

Expert opinion on pharmacotherapy, 2020-07, Vol.21 (11), p.1299-1309

2020

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Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)/AKT pathway

Bioengineered, 2022-03, Vol.13 (3), p.6794-6806

2022

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Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

Bioengineered, 2022-04, Vol.13 (4), p.11192-11201

2022

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Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway

Bioengineered, 2022-05, Vol.13 (5), p.12625-12636

2022

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Curcumin alleviates rheumatoid arthritis progression through the phosphatidylinositol 3-kinase/protein kinase B pathway: an in vitro and in vivo study

Bioengineered, 2022-05, Vol.13 (5), p.12899-12911

2022

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Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway

Bioengineered, 2021-12, Vol.12 (2), p.11909-11921

2021

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Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma

Cancer biology & therapy, 2015-01, Vol.16 (4), p.602-609

2015

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Resveratrol inhibits basic fibroblast growth factor-induced macrophage colony-stimulating factor synthesis via the PI3-kinase/Akt pathway in osteoblasts

Bioscience, biotechnology, and biochemistry, 2023-11, Vol.87 (12), p.1462-1469

2023

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Sequential conversion of PtdIns3P to PtdIns(3,5)P 2 via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy

Autophagy, 2023-04, Vol.19 (4), p.1365-1367

2023

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MicroRNA-631 deriving from bone marrow mesenchymal stem cell exosomes facilitates the malignant behavior of non-small cell lung cancer via modulating the E2F family of transcription factor 2/phosphatidylinositol 3-kinase/Akt signaling pathway

Bioengineered, 2022-04, Vol.13 (4), p.8382-8395

2022

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MicroRNA miR-23b-3p promotes osteosarcoma by targeting ventricular zone expressed PH domain-containing 1 (VEPH1)/phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway

Bioengineered, 2021-12, Vol.12 (2), p.12568-12582

2021

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Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway

Bioengineered, 2022-04, Vol.13 (4), p.11310-11320

2022

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Quercetin alleviates chronic renal failure by targeting the PI3k/Akt pathway

Bioengineered, 2021-01, Vol.12 (1), p.6538-6558

2021

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LEM domain containing 1 (LEMD1) transcriptionally activated by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by upregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

Bioengineered, 2022-04, Vol.13 (4), p.8087-8100

2022

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Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway

Bioengineered, 2021-12, Vol.12 (2), p.12227-12235

2021

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Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway

Pharmaceutical biology, 2021-01, Vol.59 (1), p.1104-1114

2021

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Up-regulation of LINC00619 promotes apoptosis and inhibits proliferation, migration and invasion while promoting apoptosis of osteosarcoma cells through inactivation of the HGF-mediated PI3K-Akt signalling pathway

Epigenetics, 2022-02, Vol.17 (2), p.147-160

2022

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Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

Gut microbes, 2021-01, Vol.13 (1), p.1-17

2021

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Targeting phosphatidylinositol 3-kinase signaling in acute myelogenous leukemia

Expert opinion on therapeutic targets, 2013-08, Vol.17 (8), p.921-936

2013

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Network pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke

Pharmaceutical biology, 2022-12, Vol.60 (1), p.119-130

2022

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Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis

Pharmaceutical biology, 2022-12, Vol.60 (1), p.417-426

2022

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miR-451 suppresses EMT and metastasis in glioma cells

Cell cycle (Georgetown, Tex.), 2021-07, Vol.20 (13), p.1270-1278

2021

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Vitexin suppresses the proliferation, angiogenesis and stemness of endometrial cancer through the PI3K/AKT pathway

Pharmaceutical biology, 2023-12, Vol.61 (1), p.581-589

2023

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An update on PTEN modulators - a patent review

Expert opinion on therapeutic patents, 2019-11, Vol.29 (11), p.881-889

2019

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Taxifolin, a novel food, attenuates acute alcohol-induced liver injury in mice through regulating the NF-κB-mediated inflammation and PI3K/Akt signalling pathways

Pharmaceutical biology, 2021-01, Vol.59 (1), p.866-877

2021

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Duvelisib for the treatment of chronic lymphocytic leukemia

Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)/AKT pathway

Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway

Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway

Curcumin alleviates rheumatoid arthritis progression through the phosphatidylinositol 3-kinase/protein kinase B pathway: an in vitro and in vivo study

Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway

Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma

Resveratrol inhibits basic fibroblast growth factor-induced macrophage colony-stimulating factor synthesis via the PI3-kinase/Akt pathway in osteoblasts

Sequential conversion of PtdIns3P to PtdIns(3,5)P 2 via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy

MicroRNA-631 deriving from bone marrow mesenchymal stem cell exosomes facilitates the malignant behavior of non-small cell lung cancer via modulating the E2F family of transcription factor 2/phosphatidylinositol 3-kinase/Akt signaling pathway

MicroRNA miR-23b-3p promotes osteosarcoma by targeting ventricular zone expressed PH domain-containing 1 (VEPH1)/phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway

Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway

Quercetin alleviates chronic renal failure by targeting the PI3k/Akt pathway

LEM domain containing 1 (LEMD1) transcriptionally activated by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by upregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway

Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway

Up-regulation of LINC00619 promotes apoptosis and inhibits proliferation, migration and invasion while promoting apoptosis of osteosarcoma cells through inactivation of the HGF-mediated PI3K-Akt signalling pathway

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

Targeting phosphatidylinositol 3-kinase signaling in acute myelogenous leukemia

Network pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke

Osthole exhibits an antitumor effect in retinoblastoma through inhibiting the PI3K/AKT/mTOR pathway via regulating the hsa_circ_0007534/miR-214-3p axis

miR-451 suppresses EMT and metastasis in glioma cells

Vitexin suppresses the proliferation, angiogenesis and stemness of endometrial cancer through the PI3K/AKT pathway

An update on PTEN modulators - a patent review

Taxifolin, a novel food, attenuates acute alcohol-induced liver injury in mice through regulating the NF-κB-mediated inflammation and PI3K/Akt signalling pathways

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