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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4908-4927

2015

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Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

Cell, 2016-08, Vol.166 (5), p.1163-1175.e12

2016

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IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

FEBS letters, 2009-06, Vol.583 (12), p.1817-1824

2009

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The biology of IQGAP proteins: beyond the cytoskeleton

EMBO reports, 2015-04, Vol.16 (4), p.427-446

2015

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Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11381-11386

2011

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Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4472-4484

2018

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RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

The Journal of cell biology, 2013-09, Vol.202 (6), p.917-935

2013

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SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

Science (American Association for the Advancement of Science), 2024-03, Vol.383 (6686), p.eadk1291

2024

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CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Cell death & disease, 2019-11, Vol.10 (12), p.900-14, Article 900

2019

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Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses

Cell, 2012-11, Vol.151 (4), p.709-723

2012

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Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders

Molecular and cellular neuroscience, 2018-09, Vol.91, p.140-150

2018

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SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

eLife, 2020-06, Vol.9

2020

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Tau exacerbates excitotoxic brain damage in an animal model of stroke

Nature communications, 2017-09, Vol.8 (1), p.473-15, Article 473

2017

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Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

European journal of medicinal chemistry, 2023-02, Vol.248, p.115104, Article 115104

2023

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Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Cell death and differentiation, 2017-01, Vol.24 (1), p.15-25

2017

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Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Human molecular genetics, 2015-07, Vol.24 (14), p.4006-4023

2015

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Sar1 GTPase Activity Is Regulated by Membrane Curvature

The Journal of biological chemistry, 2016-01, Vol.291 (3), p.1014-1027

2016

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Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Cancer research (Chicago, Ill.), 2017-08, Vol.77 (16), p.4328-4341

2017

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

The Journal of cell biology, 2024-09, Vol.223 (9)

2024

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The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

Current biology, 2010-09, Vol.20 (18), p.1654-1659

2010

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The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Scientific reports, 2019-06, Vol.9 (1), p.9126-15, Article 9126

2019

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Bile Acids Activate YAP to Promote Liver Carcinogenesis

Cell reports (Cambridge), 2013-11, Vol.5 (4), p.1060-1069

2013

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Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

The Journal of biological chemistry, 2018-03, Vol.293 (10), p.3685-3699

2018

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Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

Structure (London), 2020-03, Vol.28 (3), p.290-300.e4

2020

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Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing

Neuron (Cambridge, Mass.), 2023-05, Vol.111 (10), p.1637-1650.e5

2023

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Phosphorylation of Synaptic GTPase-activating Protein (synGAP) by Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) and Cyclin-dependent Kinase 5 (CDK5) Alters the Ratio of Its GAP Activity toward Ras and Rap GTPases

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

The biology of IQGAP proteins: beyond the cytoskeleton

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex

SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses

Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders

SynGAP isoforms differentially regulate synaptic plasticity and dendritic development

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

Block one, unleash a hundred. Mechanisms of DAB2IP inactivation in cancer

Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

Sar1 GTPase Activity Is Regulated by Membrane Curvature

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Bile Acids Activate YAP to Promote Liver Carcinogenesis

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing

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