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Noncoding RNA actions through IGFs and IGF binding proteins in cancer

Oncogene, 2022-06, Vol.41 (25), p.3385-3393

2022

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Insulin and IGF receptor signalling in neural-stem-cell homeostasis

Nature reviews. Endocrinology, 2015-03, Vol.11 (3), p.161

2015

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Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

Gene therapy, 2014-09, Vol.21 (9), p.811-819

2014

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CHK1 inhibition exacerbates replication stress induced by IGF blockade

Oncogene, 2022-01, Vol.41 (4), p.476-488

2022

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TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Nature communications, 2015-08, Vol.6 (1), p.7951-7951, Article 7951

2015

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Determinants of IGF-II influencing stability, receptor binding and activation

Scientific reports, 2022-03, Vol.12 (1), p.4695-4695, Article 4695

2022

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Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Nature communications, 2022-07, Vol.13 (1), p.4434-4434, Article 4434

2022

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Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration

Cell death and differentiation, 2020-08, Vol.27 (8), p.2344-2362

2020

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A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS Fli1-regulated microRNAs

Oncogene, 2011-12, Vol.30 (49), p.4910-4920

2011

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rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

Gene therapy, 2016-03, Vol.23 (3), p.247-255

2016

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IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR

Oncogene, 2011-05, Vol.30 (20), p.2345-2355

2011

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Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Nature communications, 2023-10, Vol.14 (1), p.6271-6271, Article 6271

2023

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Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

British journal of cancer, 2020-03, Vol.122 (5), p.624-629

2020

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ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

Cell death and differentiation, 2014-08, Vol.21 (8), p.1262-1274

2014

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A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk

British journal of cancer, 2005-04, Vol.92 (7), p.1283-1287

2005

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Vitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study

Scientific reports, 2018-01, Vol.8 (1), p.100, Article 100

2018

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VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

Cell discovery, 2023-08, Vol.9 (1), p.83-83, Article 83

2023

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Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours

British journal of cancer, 2020-04, Vol.122 (9), p.1324-1332

2020

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Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

Gene therapy, 2020-02, Vol.27 (1-2), p.62-73

2020

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GLP-1 and IGF-I levels are elevated in late infancy in low birth weight infants, independently of GLP-1 receptor polymorphisms and neonatal nutrition

International Journal of Obesity, 2018-04, Vol.42 (4), p.915-918

2018

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Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial

European journal of clinical nutrition, 2003-09, Vol.57 (9), p.1079-1088

2003

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Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells

British journal of cancer, 2014-06, Vol.110 (12), p.2865-2873

2014

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growth hormone--IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania

International Journal of Obesity, 2011-03, Vol.35 (3), p.364-372

2011

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IGF-I and IGFBP-3 concentrations at 2 years: associations with anthropometry and milk consumption in an Indian cohort

European journal of clinical nutrition, 2018-04, Vol.72 (4), p.564-571

2018

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Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Noncoding RNA actions through IGFs and IGF binding proteins in cancer

Insulin and IGF receptor signalling in neural-stem-cell homeostasis

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo

CHK1 inhibition exacerbates replication stress induced by IGF blockade

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Determinants of IGF-II influencing stability, receptor binding and activation

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex

Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS Fli1-regulated microRNAs

rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair

IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR

Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma

ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation

A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk

Vitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study

VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours

Human umbilical cord perivascular cells-derived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice

GLP-1 and IGF-I levels are elevated in late infancy in low birth weight infants, independently of GLP-1 receptor polymorphisms and neonatal nutrition

Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial

Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells

growth hormone--IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania

IGF-I and IGFBP-3 concentrations at 2 years: associations with anthropometry and milk consumption in an Indian cohort

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