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Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis

Journal of the American Chemical Society, 2020-05, Vol.142 (20), p.9493-9500

2020

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The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement

European journal of nuclear medicine and molecular imaging, 2024-03, Vol.51 (4), p.978-990

2024

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Synthesis of a dual carbon‐14‐labeled calcitonin gene‐related peptide receptor antagonist for use in a human absorption–distribution–metabolism–elimination study

Journal of labelled compounds & radiopharmaceuticals, 2022-05, Vol.65 (5), p.126-139

2022

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Synthesis of carbon‐14 and stable isotope labeled Censavudine

Journal of labelled compounds & radiopharmaceuticals, 2022-04, Vol.65 (4), p.112-122

2022

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Synthesis of stable‐isotope‐labeled N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide and N‐(3‐dimethylaminopropyl)‐N′‐ethylurea

Journal of labelled compounds & radiopharmaceuticals, 2020-11, Vol.63 (13), p.526-530

2020

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Synthesis of tritium labeled 30‐KDa PEG and conjugation to form [3H]Pegbelfermin

Journal of labelled compounds & radiopharmaceuticals, 2021-10, Vol.64 (12), p.477-481

2021

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Metabolism and disposition of dasatinib after oral administration to humans

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1357-1364

2008

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The synthesis and analysis of [phenyl-14C(U)]BMS-770767 and [13C6]BMS-770767 for use in discovery biotransformation, human ADME and bioanalytical studies

Journal of labelled compounds & radiopharmaceuticals, 2016-12, Vol.59 (14), p.657-664

2016

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The syntheses of isotopically labelled CB-1 antagonists for the treatment of obesity

Journal of labelled compounds & radiopharmaceuticals, 2016-12, Vol.59 (14), p.665-672

2016

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Synthesis of isotopically labeled daclatasvir for use in human clinical studies

Journal of labelled compounds & radiopharmaceuticals, 2016-04, Vol.59 (4), p.164-170

2016

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The syntheses of [14C]BMS-823778 for use in a human ADME clinical study and of [13CD3 13CD2]BMT-094817, a stable-isotope labeled standard of a newly detected human metabolite

Journal of labelled compounds & radiopharmaceuticals, 2016-05, Vol.59 (6), p.255-259

2016

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Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human

Drug metabolism and disposition, 2012-07, Vol.40 (7), p.1345-1356

2012

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Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach

Journal of labelled compounds & radiopharmaceuticals, 2015-07, Vol.58 (9), p.361-369

2015

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Synthesis and Preclinical Evaluation of a 68Ga-Labeled Adnectin, 68Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression

The Journal of nuclear medicine (1978), 2021-09, Vol.62 (9), p.1228-1234

2021

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Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates

Journal of labelled compounds & radiopharmaceuticals, 2014-07, Vol.57 (9), p.579-583

2014

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Synthesis of unlabelled and stable‐isotope–labelled glucuronide metabolites of dapagliflozin and synthesis of stable‐isotope–labelled dapagliflozin

Journal of labelled compounds & radiopharmaceuticals, 2017-03, Vol.60 (3), p.150-159

2017

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Distinguishing a phosphate ester prodrug from its isobaric sulfate metabolite by mass spectrometry without the metabolite standard

Rapid communications in mass spectrometry, 2009-10, Vol.23 (19), p.3107-3113

2009

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Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration

Acta pharmaceutica Sinica. B, 2016-09, Vol.6 (5), p.460-467

2016

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An alternative and robust synthesis of [13C4]Baraclude® (entecavir)

Journal of labelled compounds & radiopharmaceuticals, 2013-10, Vol.56 (12), p.632-636

2013

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Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.303-315

2008

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Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1341-1356

2008

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Synthesis and Preclinical Evaluation of a 68 Ga-Labeled Adnectin, 68 Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression

Journal of Nuclear Medicine, 2021-09, Vol.62 (9), p.1228-1234

2021

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Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer

Molecular imaging and biology, 2024-04, Vol.26 (2), p.301-309

2024

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Biotransformation Profiling of [14C]Ixabepilone in Human Plasma, Urine and Feces Samples Using Accelerator Mass Spectrometry (AMS)

DRUG METABOLISM AND PHARMACOKINETICS, 2009-01, Vol.24 (6), p.511-522

2009

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An improved synthesis of [2-14C]2, 5-dichloropyrimidine

Journal of labelled compounds & radiopharmaceuticals, 2012-06, Vol.55 (8), p.300-302

2012

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Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis

The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement

Synthesis of a dual carbon‐14‐labeled calcitonin gene‐related peptide receptor antagonist for use in a human absorption–distribution–metabolism–elimination study

Synthesis of carbon‐14 and stable isotope labeled Censavudine

Synthesis of stable‐isotope‐labeled N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide and N‐(3‐dimethylaminopropyl)‐N′‐ethylurea

Synthesis of tritium labeled 30‐KDa PEG and conjugation to form [3H]Pegbelfermin

Metabolism and disposition of dasatinib after oral administration to humans

The synthesis and analysis of [phenyl-14C(U)]BMS-770767 and [13C6]BMS-770767 for use in discovery biotransformation, human ADME and bioanalytical studies

The syntheses of isotopically labelled CB-1 antagonists for the treatment of obesity

Synthesis of isotopically labeled daclatasvir for use in human clinical studies

The syntheses of [14C]BMS-823778 for use in a human ADME clinical study and of [13CD3 13CD2]BMT-094817, a stable-isotope labeled standard of a newly detected human metabolite

Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human

Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach

Synthesis and Preclinical Evaluation of a 68Ga-Labeled Adnectin, 68Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression

Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates

Synthesis of unlabelled and stable‐isotope–labelled glucuronide metabolites of dapagliflozin and synthesis of stable‐isotope–labelled dapagliflozin

Distinguishing a phosphate ester prodrug from its isobaric sulfate metabolite by mass spectrometry without the metabolite standard

Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration

An alternative and robust synthesis of [13C4]Baraclude® (entecavir)

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs

Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys

Synthesis and Preclinical Evaluation of a 68 Ga-Labeled Adnectin, 68 Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression

Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer

Biotransformation Profiling of [14C]Ixabepilone in Human Plasma, Urine and Feces Samples Using Accelerator Mass Spectrometry (AMS)

An improved synthesis of [2-14C]2, 5-dichloropyrimidine

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