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Efficacy of MEK inhibition in patients with histiocytic neoplasms

Nature (London), 2019-03, Vol.567 (7749), p.521-524

2019

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Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling

Cancer research (Chicago, Ill.), 2018-06, Vol.78 (11), p.3041-3053

2018

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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Nature genetics, 2012-02, Vol.44 (2), p.133-139

2012

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The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2

The Journal of biological chemistry, 2017-05, Vol.292 (21), p.8750-8761

2017

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Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells

Science signaling, 2011-03, Vol.4 (166), p.ra17

2011

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Direct Phosphorylation and Regulation of Poly(ADP-Ribose) Polymerase-1 by Extracellular Signal-Regulated Kinases 1/2

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.7136-7141

2006

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Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation

The Journal of biological chemistry, 2016-02, Vol.291 (7), p.3569-3580

2016

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Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells

The Journal of biological chemistry, 2014-12, Vol.289 (49), p.34366-34377

2014

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Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

The Journal of biological chemistry, 2013-11, Vol.288 (47), p.33966-33977

2013

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Germline Mutations in Genes within the MAPK Pathway Cause Cardio-Facio-Cutaneous Syndrome

Science (American Association for the Advancement of Science), 2006-03, Vol.311 (5765), p.1287-1290

2006

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A Novel MEK-ERK-AMPK Signaling Axis Controls Chemokine Receptor CCR7-dependent Survival in Human Mature Dendritic Cells

The Journal of biological chemistry, 2015-01, Vol.290 (2), p.827-840

2015

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p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner

The Journal of biological chemistry, 2013-07, Vol.288 (27), p.20093-20099

2013

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Sp1 and AP-1 Regulate Expression of the Human Gene VIL2 in Esophageal Carcinoma Cells

The Journal of biological chemistry, 2009-03, Vol.284 (12), p.7995-8004

2009

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The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

Blood, 2008-01, Vol.111 (2), p.846-855

2008

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Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy

Nucleic acids research, 2016-12, Vol.44 (21), p.10150

2016

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Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

The Journal of biological chemistry, 2011-10, Vol.286 (41), p.35763-35769

2011

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Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells

Blood, 2012-01, Vol.119 (1), p.170-179

2012

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Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation

The Journal of biological chemistry, 2017-10, Vol.292 (43), p.17919-17927

2017

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Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone

The Journal of immunology (1950), 2012-05, Vol.188 (9), p.4621-4630

2012

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Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin

The FASEB journal, 2015-09, Vol.29 (9), p.3762-3772

2015

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Crucial requirement of ERK/MAPK signaling in respiratory tract development

Development (Cambridge), 2014-08, Vol.141 (16), p.3197-3211

2014

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Ras/Mitogen-activated Protein Kinase (MAPK) Signaling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI

The Journal of biological chemistry, 2011-07, Vol.286 (26), p.23077-23092

2011

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MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome

American journal of respiratory cell and molecular biology, 2022-05, Vol.66 (5), p.555-563

2022

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Helicobacter pylori Lipopolysaccharides Upregulate Toll-Like Receptor 4 Expression and Proliferation of Gastric Epithelial Cells via the MEK1/2-ERK1/2 Mitogen-Activated Protein Kinase Pathway

Infection and Immunity, 2010-01, Vol.78 (1), p.468-476

2010

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Efficacy of MEK inhibition in patients with histiocytic neoplasms

Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia

The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells

Direct Phosphorylation and Regulation of Poly(ADP-Ribose) Polymerase-1 by Extracellular Signal-Regulated Kinases 1/2

Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation

Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells

Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

Germline Mutations in Genes within the MAPK Pathway Cause Cardio-Facio-Cutaneous Syndrome

A Novel MEK-ERK-AMPK Signaling Axis Controls Chemokine Receptor CCR7-dependent Survival in Human Mature Dendritic Cells

p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner

Sp1 and AP-1 Regulate Expression of the Human Gene VIL2 in Esophageal Carcinoma Cells

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy

Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells

Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation

Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone

Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin

Crucial requirement of ERK/MAPK signaling in respiratory tract development

Ras/Mitogen-activated Protein Kinase (MAPK) Signaling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI

MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with Acute Respiratory Distress Syndrome Outcome

Helicobacter pylori Lipopolysaccharides Upregulate Toll-Like Receptor 4 Expression and Proliferation of Gastric Epithelial Cells via the MEK1/2-ERK1/2 Mitogen-Activated Protein Kinase Pathway

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