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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7818-7839

2016

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Pharmacokinetics and metabolism of [14C]eplerenone after oral administration to humans

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1448-1455

2003

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Dynamic modeling of cytochrome P450 inhibition in vitro: impact of inhibitor depletion on IC₅₀ shift

Drug metabolism and disposition, 2013-07, Vol.41 (7), p.1433

2013

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Species difference in glucuronidation formation kinetics with a selective mTOR inhibitor

Drug metabolism and disposition, 2014-04, Vol.42 (4), p.707-717

2014

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Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators

European journal of medicinal chemistry, 2017-09, Vol.137, p.63-75

2017

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Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5

Drug metabolism and disposition, 2002-12, Vol.30 (12), p.1344-1351

2002

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Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

BMC pharmacology, 2012-05, Vol.12 (1), p.5-5, Article 5

2012

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Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5990-6017

2017

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Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors

Drug metabolism and disposition, 2013-01, Vol.41 (1), p.238-247

2013

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Species Differences in Distribution and Prediction of Human V ss from Preclinical Data

Drug metabolism and disposition, 2011-11, Vol.39 (11), p.2103-2116

2011

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Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

Drug metabolism letters, 2009-04, Vol.3 (2), p.70-77

2009

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Prediction of V ss from In Vitro Tissue-Binding Studies

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.115-121

2010

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Dynamic Modeling of Cytochrome P450 Inhibition In Vitro: Impact of Inhibitor Depletion on IC 50 Shift

Drug metabolism and disposition, 2013-07, Vol.41 (7), p.1433-1441

2013

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An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

Drug metabolism letters, 2008-01, Vol.2 (1), p.51-59

2008

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na V 1.7 Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7818-7839

2016

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Species differences in distribution and prediction of human V(ss) from preclinical data

Drug metabolism and disposition, 2011-11, Vol.39 (11), p.2103

2011

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An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2C9 in human liver microsomes

Drug metabolism letters, 2008-01, Vol.2 (1), p.51

2008

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Esterase activities in the blood, liver and intestine of several preclinical species and humans

Drug metabolism letters, 2009-04, Vol.3 (2), p.70

2009

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Long-acting [kappa] opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

BMC pharmacology, 2012-01, Vol.12 (1)

2012

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Prediction of V(ss) from in vitro tissue-binding studies

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.115

2010

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Leaders in Sales and Sales Management

The Journal of personal selling & sales management, 1981-01, Vol.1 (1), p.90-91

1981

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Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

The Journal of physiology, 2018-12, Vol.596 (23), p.5535-5569

2018

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Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database

Molecular genetics and metabolism, 2016-08, Vol.118 (4), p.272-281

2016

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Comparison of Methods of Initial Ascertainment in 58 Cases of Propionic Acidemia Enrolled in the Inborn Errors of Metabolism Information System Reveals Significant Differences in Time to Evaluation and Symptoms at Presentation

The Journal of pediatrics, 2017-01, Vol.180, p.200-205.e8

2017

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Measuring Pediatric Hospital Readmission Rates to Drive Quality Improvement

Academic pediatrics, 2014-09, Vol.14 (5), p.S39-S46

2014

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Pharmacokinetics and metabolism of [14C]eplerenone after oral administration to humans

Dynamic modeling of cytochrome P450 inhibition in vitro: impact of inhibitor depletion on IC₅₀ shift

Species difference in glucuronidation formation kinetics with a selective mTOR inhibitor

Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators

Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors

Species Differences in Distribution and Prediction of Human V ss from Preclinical Data

Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

Prediction of V ss from In Vitro Tissue-Binding Studies

Dynamic Modeling of Cytochrome P450 Inhibition In Vitro: Impact of Inhibitor Depletion on IC 50 Shift

An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na V 1.7 Inhibitors

Species differences in distribution and prediction of human V(ss) from preclinical data

An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2C9 in human liver microsomes

Esterase activities in the blood, liver and intestine of several preclinical species and humans

Long-acting [kappa] opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

Prediction of V(ss) from in vitro tissue-binding studies

Leaders in Sales and Sales Management

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database

Comparison of Methods of Initial Ascertainment in 58 Cases of Propionic Acidemia Enrolled in the Inborn Errors of Metabolism Information System Reveals Significant Differences in Time to Evaluation and Symptoms at Presentation

Measuring Pediatric Hospital Readmission Rates to Drive Quality Improvement

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