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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (50), p.20224-20229

2013

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Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes

Journal of controlled release, 2018-11, Vol.290, p.75-87

2018

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LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974

Scientific reports, 2017-01, Vol.7 (1), p.41612-41612, Article 41612

2017

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LGK974 suppresses the formation of deep vein thrombosis in mice with sepsis

International immunopharmacology, 2024-01, Vol.127, p.111458-111458, Article 111458

2024

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Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines

International journal of molecular sciences, 2021-04, Vol.22 (8), p.4263

2021

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Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma

BioMed research international, 2020, Vol.2020 (2020), p.1-16

2020

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Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug

Fundamental & clinical pharmacology, 2020-02, Vol.34 (1), p.51-64

2020

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LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways

Experimental and Molecular Medicine, 2021, 53(0), , pp.1-15

2021

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The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling

International journal of oncology, 2017-08, Vol.51 (2), p.545-554

2017

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LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson’s disease by interfering with the WNT/β-CATENIN pathway

Toxicology (Amsterdam), 2018-12, Vol.410, p.65-72

2018

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Porcupine inhibitor LGK‐974 inhibits Wnt/β‐catenin signaling and modifies tumor‐associated macrophages resulting in inhibition of the malignant behaviors of non‐small cell lung cancer cells

Molecular medicine reports, 2021-08, Vol.24 (2), Article 550

2021

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Studies on the retention mechanism of solutes in hydrophilic interaction chromatography using stoichiometric displacement theory I. The linear relationship of lgk' vs. lg[H2O]

Talanta (Oxford), 2018-01, Vol.176, p.499-508

2018

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LGK974 Potentiates the Lethality of TRAIL in Hepatocellular Carcinoma Cells by Inducing Apoptosis via Suppressing NF-κB Signaling Pathway

Indian Journal of Pharmaceutical Sciences, 2022, Vol.83 (s6)

2022

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Multi Variate Feature Extraction and Feature Selection using LGKFS Algorithm for Detecting Alzheimer’s Disease

Indian journal of science and technology, 2023-06, Vol.16 (22), p.1665-1675

2023

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Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone

JBMR plus, 2024-05, Vol.8 (5), p.ziae011-ziae011

2024

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A note on the bicategory of Landau-Ginzburg models (LGK)

Surveys in mathematics and its applications, 2024-02, Vol.19 (2024), p.1-40

Yves Baudelaire Fomatati

2024

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BEV-LGKD: A Unified LiDAR-Guided Knowledge Distillation Framework for Multi-View BEV 3D Object Detection

IEEE transactions on intelligent vehicles, 2024-01, Vol.9 (1), p.2489-2498

2024

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Porcupine inhibitor LGK-974 inhibits Wnt/[beta]-catenin signaling and modifies tumor-associated macrophages resulting in inhibition of the malignant behaviors of non-small cell lung cancer cells

Molecular medicine reports, 2021-08, Vol.24 (2)

2021

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Effect of corneal contact lens wear on healing time and comfort post LGK for treatment of SCCEDs in boxers

Veterinary ophthalmology, 2015-09, Vol.18 (5), p.364-370

2015

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Anmerkung zu OLG Köln, Hinweisbeschl. v. 10.12.2014 und Beschl. v. 2.2.2015 – 5 U 75/14 (LG Köln)

Medizinrecht, 2015-10, Vol.33 (10), p.739-740

Jaeger, Lothar

2015

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Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway

Pharmacological research, 2021-05, Vol.167, p.105532-105532, Article 105532

2021

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Structure and mechanism of LGK: insights into the bioconversion of levoglucosan

Acta crystallographica. Section A, Foundations and advances, 2014-08, Vol.70 (a1), p.C1205-C1205

2014

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Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells

Journal of neuropathology and experimental neurology, 2015-09, Vol.74 (9), p.889-900

2015

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KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway

Cell & bioscience, 2021-04, Vol.11 (1), p.73-73, Article 73

2021

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Modeling and comparison of alternative approaches for sector duration optimization in a dedicated radiosurgery system

Physics in medicine & biology, 2018-07, Vol.63 (15), p.155009-155009

2018

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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes

LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974

LGK974 suppresses the formation of deep vein thrombosis in mice with sepsis

Targeting of Deregulated Wnt/β-Catenin Signaling by PRI-724 and LGK974 Inhibitors in Germ Cell Tumor Cell Lines

Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma

Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug

LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways

The Wnt inhibitor LGK-974 enhances radiosensitivity of HepG2 cells by modulating Nrf2 signaling

LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson’s disease by interfering with the WNT/β-CATENIN pathway

Porcupine inhibitor LGK‐974 inhibits Wnt/β‐catenin signaling and modifies tumor‐associated macrophages resulting in inhibition of the malignant behaviors of non‐small cell lung cancer cells

Studies on the retention mechanism of solutes in hydrophilic interaction chromatography using stoichiometric displacement theory I. The linear relationship of lgk' vs. lg[H2O]

LGK974 Potentiates the Lethality of TRAIL in Hepatocellular Carcinoma Cells by Inducing Apoptosis via Suppressing NF-κB Signaling Pathway

Multi Variate Feature Extraction and Feature Selection using LGKFS Algorithm for Detecting Alzheimer’s Disease

Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone

A note on the bicategory of Landau-Ginzburg models (LGK)

BEV-LGKD: A Unified LiDAR-Guided Knowledge Distillation Framework for Multi-View BEV 3D Object Detection

Porcupine inhibitor LGK-974 inhibits Wnt/[beta]-catenin signaling and modifies tumor-associated macrophages resulting in inhibition of the malignant behaviors of non-small cell lung cancer cells

Effect of corneal contact lens wear on healing time and comfort post LGK for treatment of SCCEDs in boxers

Anmerkung zu OLG Köln, Hinweisbeschl. v. 10.12.2014 und Beschl. v. 2.2.2015 – 5 U 75/14 (LG Köln)

Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway

Structure and mechanism of LGK: insights into the bioconversion of levoglucosan

Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells

KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway

Modeling and comparison of alternative approaches for sector duration optimization in a dedicated radiosurgery system

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