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Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

Nature communications, 2024-03, Vol.15 (1), p.2612-2612

2024

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Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

Nature communications, 2015-01, Vol.6 (1), p.5937-5937, Article 5937

2015

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Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

Scientific reports, 2023-02, Vol.13 (1), p.1889-1889, Article 1889

2023

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At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature reviews. Clinical oncology, 2022-07, Vol.19 (7), p.471-485

2022

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The role of PI3Kγ in the immune system: new insights and translational implications

Nature reviews. Immunology, 2022-11, Vol.22 (11), p.687

2022

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Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency

Mucosal immunology, 2019-09, Vol.12 (5), p.1187-1200

2019

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Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Scientific reports, 2022-04, Vol.12 (1), p.5924-5924, Article 5924

2022

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The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Scientific reports, 2019-08, Vol.9 (1), p.11317-12, Article 11317

2019

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Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

Nature communications, 2018-07, Vol.9 (1), p.2639-13, Article 2639

2018

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TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Nature (London), 2020-02, Vol.578 (7796), p.605-609

2020

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The present and future of PI3K inhibitors for cancer therapy

Nature cancer, 2021-06, Vol.2 (6), p.587

2021

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A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

Nature cell biology, 2015-07, Vol.17 (7), p.930

2015

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A class of highly selective inhibitors bind to an active state of PI3Kγ

Nature chemical biology, 2019-04, Vol.15 (4), p.348

2019

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Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines

Scientific reports, 2018-01, Vol.8 (1), p.1652-12, Article 1652

2018

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p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

Nature communications, 2014-01, Vol.5 (1), p.3146-3146, Article 3146

2014

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A novel lncRNA LNC_000052 leads to the dysfunction of osteoporotic BMSCs via the miR-96-5p-PIK3R1 axis

Cell death & disease, 2020-09, Vol.11 (9), p.795-795, Article 795

2020

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PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Nature (London), 2023-05, Vol.617 (7959), p.139-146

2023

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Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

Oncogene, 2016-06, Vol.35 (22), p.2873-2880

2016

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PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex

Cell death & disease, 2021-03, Vol.12 (3), p.276-276, Article 276

2021

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Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells

Cell death & disease, 2015-12, Vol.6 (12), p.e2020-e2020

2015

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FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

Nature cell biology, 2013-05, Vol.15 (5), p.472

2013

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P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

Acta pharmacologica Sinica, 2022-02, Vol.43 (2), p.457-469

2022

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VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

Nature cell biology, 2011-10, Vol.13 (10), p.1202

2011

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Metabolic drug survey highlights cancer cell dependencies and vulnerabilities

Nature communications, 2021-12, Vol.12 (1), p.7190-7190, Article 7190

2021

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Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Nature communications, 2018-04, Vol.9 (1), p.1513-14, Article 1513

2018

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Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

The role of PI3Kγ in the immune system: new insights and translational implications

Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

The present and future of PI3K inhibitors for cancer therapy

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

A class of highly selective inhibitors bind to an active state of PI3Kγ

Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

A novel lncRNA LNC_000052 leads to the dysfunction of osteoporotic BMSCs via the miR-96-5p-PIK3R1 axis

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex

Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

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