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AOP Report: An Upstream Network for Reduced Androgen Signaling Leading to Altered Gene Expression of Androgen Receptor–Responsive Genes in Target Tissues

Environmental toxicology and chemistry, 2024-11, Vol.43 (11), p.2329-2337

2024

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Schisandra chinensis lignans improve insulin resistance by targeting TLR4 and activating IRS-1/PI3K/AKT and NF-κB signaling pathways

International immunopharmacology, 2024-12, Vol.142 (Pt A), p.113069, Article 113069

2024

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Effect of Mifepristone on Migration and Proliferation of Oral Cancer Cells

International journal of molecular sciences, 2024-08, Vol.25 (16), p.8777

2024

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An in silico molecular docking and simulation study to identify potential anticancer phytochemicals targeting the RAS signaling pathway

PloS one, 2024-09, Vol.19 (9), p.e0310637

2024

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Unraveling TRPV1's Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin

Molecules (Basel, Switzerland), 2024-10, Vol.29 (19), p.4729

2024

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An Ingenane-Type Diterpene from Euphorbia kansui Promoted Cell Apoptosis and Macrophage Polarization via the Regulation of PKC Signaling Pathways

International journal of molecular sciences, 2024-09, Vol.25 (18), p.10123

2024

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Advances in the application and mechanism of bioactive peptides in the treatment of inflammation

Frontiers in immunology, 2024, Vol.15, p.1413179

2024

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Atmospheric pressure plasma preconditioning reduces oxygen and glucose deprivation induced human neuronal SH-SY5Y cells apoptosis by activating protective autophagy and ROS/AMPK/mTOR pathway

Cellular signalling, 2024-11, Vol.123, p.111350, Article 111350

2024

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Clinical applications of STING agonists in cancer immunotherapy: current progress and future prospects

Frontiers in immunology, 2024-10, Vol.15, p.1485546

2024

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Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view

Chemico-biological interactions, 2024-10, Vol.402, p.111218, Article 111218

2024

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Sulfated Chinese yam polysaccharide exert anti‐inflammatory potential via MAPK/NF‐κB signaling pathways in a co‐culture system and LPS‐induced acute inflammatory mice model

Journal of food science, 2024-10, Vol.89 (10), p.6720-6732

2024

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WYC-209 suppresses gastric cancer by down-regulating FGF18 via inactivating the STAT3 signaling pathway

European journal of pharmacology, 2024-11, Vol.983, p.176957, Article 176957

2024

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Adipocyte-conditioned medium induces tamoxifen resistance by activating PI3K/Akt/mTOR pathway in estrogen receptor-positive breast cancer cells

Biochimica et biophysica acta. Molecular cell research, 2024-10, Vol.1871 (7), p.119821, Article 119821

2024

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Downregulation of SSR2 Enhances Hepatocellular Carcinoma Cisplatin Sensitivity via the Hippo Pathway

Frontiers in bioscience (Landmark. Print), 2024-08, Vol.29 (8), p.299

2024

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Targeting Molecular Signaling Pathways and Cytokine Responses to Modulate c-MYC in Acute Myeloid Leukemia

Frontiers in bioscience (Scholar edition), 2024-09, Vol.16 (3), p.15

2024

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Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction

Scientific reports, 2024-09, Vol.14 (1), p.22103-16, Article 22103

2024

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Osteogenic mechanism of deciduous teeth periodontal ligament stem cells in inflammatory environment

Brazilian journal of medical and biological research, 2024, Vol.57, p.e13606

2024

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Gypenoside inhibits gastric cancer proliferation by suppressing glycolysis via the Hippo pathway

Scientific reports, 2024-08, Vol.14 (1), p.19003-13

2024

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Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer

Molecular medicine (Cambridge, Mass.), 2024-09, Vol.30 (1), p.166-21, Article 166

2024

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Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway

Molecular medicine (Cambridge, Mass.), 2024-09, Vol.30 (1), p.160-16, Article 160

2024

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Zhimu-Huangbai herb-pair ameliorates hepatic steatosis in mice by regulating IRE1α/XBP1s pathway to inhibit SREBP-1c

Phytomedicine (Stuttgart), 2024-11, Vol.134, p.156017, Article 156017

2024

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Synthesis and Anti-Liver Fibrosis Research of Aspartic Acid Derivatives

Molecules (Basel, Switzerland), 2024-10, Vol.29 (19), p.4774

2024

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α-linolenic acid mitigates microglia-mediated neuroinflammation of schizophrenia in mice by suppressing the NF-κB/NLRP3 pathway via binding GPR120-β-arrestin 2

International immunopharmacology, 2024-12, Vol.142 (Pt A), p.113047, Article 113047

2024

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Design, Synthesis, and Anticancer Activity of Novel Enmein-Type Diterpenoid Derivatives Targeting the PI3K/Akt/mTOR Signaling Pathway

Molecules (Basel, Switzerland), 2024-08, Vol.29 (17), p.4066

2024

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Inhibitors of the mTOR signaling pathway can play an important role in breast cancer immunopathogenesis

Cell biology international, 2024-11, Vol.48 (11), p.1601-1611

2024

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AOP Report: An Upstream Network for Reduced Androgen Signaling Leading to Altered Gene Expression of Androgen Receptor–Responsive Genes in Target Tissues

Schisandra chinensis lignans improve insulin resistance by targeting TLR4 and activating IRS-1/PI3K/AKT and NF-κB signaling pathways

Effect of Mifepristone on Migration and Proliferation of Oral Cancer Cells

An in silico molecular docking and simulation study to identify potential anticancer phytochemicals targeting the RAS signaling pathway

Unraveling TRPV1's Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin

An Ingenane-Type Diterpene from Euphorbia kansui Promoted Cell Apoptosis and Macrophage Polarization via the Regulation of PKC Signaling Pathways

Advances in the application and mechanism of bioactive peptides in the treatment of inflammation

Atmospheric pressure plasma preconditioning reduces oxygen and glucose deprivation induced human neuronal SH-SY5Y cells apoptosis by activating protective autophagy and ROS/AMPK/mTOR pathway

Clinical applications of STING agonists in cancer immunotherapy: current progress and future prospects

Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view

Sulfated Chinese yam polysaccharide exert anti‐inflammatory potential via MAPK/NF‐κB signaling pathways in a co‐culture system and LPS‐induced acute inflammatory mice model

WYC-209 suppresses gastric cancer by down-regulating FGF18 via inactivating the STAT3 signaling pathway

Adipocyte-conditioned medium induces tamoxifen resistance by activating PI3K/Akt/mTOR pathway in estrogen receptor-positive breast cancer cells

Downregulation of SSR2 Enhances Hepatocellular Carcinoma Cisplatin Sensitivity via the Hippo Pathway

Targeting Molecular Signaling Pathways and Cytokine Responses to Modulate c-MYC in Acute Myeloid Leukemia

Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction

Osteogenic mechanism of deciduous teeth periodontal ligament stem cells in inflammatory environment

Gypenoside inhibits gastric cancer proliferation by suppressing glycolysis via the Hippo pathway

Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer

Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway

Zhimu-Huangbai herb-pair ameliorates hepatic steatosis in mice by regulating IRE1α/XBP1s pathway to inhibit SREBP-1c

Synthesis and Anti-Liver Fibrosis Research of Aspartic Acid Derivatives

α-linolenic acid mitigates microglia-mediated neuroinflammation of schizophrenia in mice by suppressing the NF-κB/NLRP3 pathway via binding GPR120-β-arrestin 2

Design, Synthesis, and Anticancer Activity of Novel Enmein-Type Diterpenoid Derivatives Targeting the PI3K/Akt/mTOR Signaling Pathway

Inhibitors of the mTOR signaling pathway can play an important role in breast cancer immunopathogenesis

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