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Largazole: from discovery to broad-spectrum therapy

Natural product reports, 2012-01, Vol.29 (4), p.449-456

2012

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N-Heterocyclic Carbene Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide

Angewandte Chemie (International ed.), 2012-06, Vol.51 (23), p.5735-5738

International ed. in English, 2012

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Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

Journal of the American Chemical Society, 2008-07, Vol.130 (26), p.8455-8459

2008

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Total Synthesis of Cyanolide A and Confirmation of Its Absolute Configuration

Organic letters, 2010-06, Vol.12 (12), p.2880-2883

2010

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An overview of naturally occurring histone deacetylase inhibitors

Current topics in medicinal chemistry, 2015-01, Vol.14 (24), p.2759

2015

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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

Science (American Association for the Advancement of Science), 2013-08, Vol.341 (6149), p.1012-1016

2013

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Chemical logic of MraY inhibition by antibacterial nucleoside natural products

Nature communications, 2019-07, Vol.10 (1), p.2917-12, Article 2917

2019

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Role of natural product diversity in chemical biology

Current opinion in chemical biology, 2011-06, Vol.15 (3), p.350-354

Hong, Jiyong

2011

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Stereoselective Synthesis of 2,6-cis-Tetrahydropyrans through a Tandem Allylic Oxidation/Oxa-Michael Reaction Promoted by the gem-Disubstituent Effect: Synthesis of (+)-Neopeltolide Macrolactone

Angewandte Chemie (International ed.), 2009-09, Vol.48 (41), p.7577-7581

2009

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Stereoselective Synthesis of 2,6-cis- and 2,6-trans-Piperidines through Organocatalytic Aza-Michael Reactions: A Facile Synthesis of (+)-Myrtine and (−)-Epimyrtine

Organic letters, 2011-02, Vol.13 (4), p.796-799

2011

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REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (46), p.28918-28921

2020

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Natural Product Synthesis at the Interface of Chemistry and Biology

Chemistry : a European journal, 2014-08, Vol.20 (33), p.10204-10212

Hong, Jiyong

2014

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Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria

Accounts of chemical research, 2021-04, Vol.54 (7), p.1623-1634

2021

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A Facile and Efficient Synthesis of 4-Hydroxy-2,6-cis-tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2′ Reaction: Protecting-Group-Free Synthesis of (±)-Diospongin A

Organic letters, 2009-11, Vol.11 (22), p.5202-5205

2009

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A Stereoselective Formal Synthesis of Leucascandrolide A

Organic letters, 2011-05, Vol.13 (10), p.2722-2725

2011

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Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans

mBio, 2023-10, Vol.14 (5), p.e0181023-e0181023

2023

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Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor

The Journal of pharmacology and experimental therapeutics, 2010-11, Vol.335 (2), p.351

2010

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Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

mBio, 2022-06, Vol.13 (3), p.e0104922-e0104922

2022

Volltextzugriff (PDF)

Stereoselective Synthesis of Tetrahydropyrans through Tandem and Organocatalytic Oxa-Michael Reactions: Synthesis of the Tetrahydropyran Cores of ent-(+)-Sorangicin A

European Journal of Organic Chemistry, 2012-02, Vol.2012 (5), p.1025-1032

2012

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Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements

Journal of proteome research, 2016-08, Vol.15 (8), p.2688-2696

2016

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Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A

Natural product reports, 2016-11, Vol.33 (12), p.1393-1424

2016

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A Small Interfering RNA Screen for Modulators of Tumor Cell Motility Identifies MAP4K4 as a Promigratory Kinase

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (10), p.3775-3780

2006

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Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

eLife, 2014-07, Vol.3, p.e03604

2014

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REV1 Inhibition Enhances Radioresistance and Autophagy

Cancers, 2021-10, Vol.13 (21), p.5290

2021

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Asymmetric Total Synthesis of ent-(−)-Roseophilin: Assignment of Absolute Configuration

Journal of the American Chemical Society, 2001-09, Vol.123 (35), p.8515-8519

2001

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Largazole: from discovery to broad-spectrum therapy

N-Heterocyclic Carbene Catalyzed Oxidative Macrolactonization: Total Synthesis of (+)-Dactylolide

Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

Total Synthesis of Cyanolide A and Confirmation of Its Absolute Configuration

An overview of naturally occurring histone deacetylase inhibitors

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

Chemical logic of MraY inhibition by antibacterial nucleoside natural products

Role of natural product diversity in chemical biology

Stereoselective Synthesis of 2,6-cis-Tetrahydropyrans through a Tandem Allylic Oxidation/Oxa-Michael Reaction Promoted by the gem-Disubstituent Effect: Synthesis of (+)-Neopeltolide Macrolactone

Stereoselective Synthesis of 2,6-cis- and 2,6-trans-Piperidines through Organocatalytic Aza-Michael Reactions: A Facile Synthesis of (+)-Myrtine and (−)-Epimyrtine

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

Natural Product Synthesis at the Interface of Chemistry and Biology

Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria

A Facile and Efficient Synthesis of 4-Hydroxy-2,6-cis-tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2′ Reaction: Protecting-Group-Free Synthesis of (±)-Diospongin A

A Stereoselective Formal Synthesis of Leucascandrolide A

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans

Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

Stereoselective Synthesis of Tetrahydropyrans through Tandem and Organocatalytic Oxa-Michael Reactions: Synthesis of the Tetrahydropyran Cores of ent-(+)-Sorangicin A

Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements

Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A

A Small Interfering RNA Screen for Modulators of Tumor Cell Motility Identifies MAP4K4 as a Promigratory Kinase

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

REV1 Inhibition Enhances Radioresistance and Autophagy

Asymmetric Total Synthesis of ent-(−)-Roseophilin: Assignment of Absolute Configuration

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