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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Drug metabolism and disposition, 2009-10, Vol.37 (10), p.2087-2094

2009

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Glucosamine Enhances Paracetamol Bioavailability by Reducing Its Metabolism

Journal of pharmaceutical sciences, 2015-01, Vol.104 (1), p.257-265

2015

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Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

PloS one, 2015-07, Vol.10 (7), p.e0132992

2015

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Computational simulations uncover enantioselective metabolism of chiral triazole fungicides by human CYP450 enzymes: A case study of tebuconazole

Ecotoxicology and environmental safety, 2024-10, Vol.284, p.116865, Article 116865

2024

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snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Nature (London), 2020-11, Vol.587 (7832), p.98-102

2020

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Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes

Toxicology in vitro, 2024-03, Vol.95, p.105739-105739, Article 105739

2024

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Interaction between Changan Granule and its main components in the plasma and CYP450 enzymes

Journal of ethnopharmacology, 2023-05, Vol.308, p.116303-116303, Article 116303

2023

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Four Different Structural Dietary Polyphenols, Especially Dihydromyricetin, Possess Superior Protective Effect on Ethanol-Induced ICE‑6 and AML-12 Cytotoxicity: The Role of CYP2E1 and Keap1-Nrf2 Pathways

Journal of agricultural and food chemistry, 2023-01, Vol.71 (3), p.1518-1530

2023

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Characterisation of cytochrome P450 isoenzyme activity in sheep liver and placental microsomes

Placenta (Eastbourne), 2023-01, Vol.131, p.82-89

2023

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Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

The Journal of biological chemistry, 2019-07, Vol.294 (28), p.10928-10941

2019

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CYP2C19 Plays a Major Role in the Hepatic N -Oxidation of Cotinine

Drug metabolism and disposition, 2023-01, Vol.51 (1), p.29-37

2023

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Absence of receptor interacting protein kinase 3 prevents ethanol‐induced liver injury

Hepatology (Baltimore, Md.), 2013-05, Vol.57 (5), p.1773-1783

2013

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Mechanistic insights into the metabolic pathways of vanillin: unraveling cytochrome P450 interaction mechanisms and implications for food safety

Organic & biomolecular chemistry, 2024-08, Vol.22 (32), p.6561-6574

2024

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Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis

PloS one, 2020-07, Vol.15 (7), p.e0235990

2020

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Antibiotics-Induced Depletion of Rat Microbiota Induces Changes in the Expression of Host Drug-Processing Genes and Pharmacokinetic Behaviors of CYPs Probe Drugs

Drug metabolism and disposition, 2023-04, Vol.51 (4), p.509-520

2023

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MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity

Scientific reports, 2017-09, Vol.7 (1), p.12331-11, Article 12331

2017

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Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in‐vitro inhibition studies

Journal of pharmacy and pharmacology, 2017-12, Vol.69 (12), p.1762-1772

2017

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Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration

Toxicological sciences, 2015-01, Vol.143 (1), p.107-115

2015

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Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress

Clinical nutrition (Edinburgh, Scotland), 2016-12, Vol.35 (6), p.1366-1373

2016

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Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol‐Inducible Cytochrome P450‐2E1–Mediated Oxidative and Nitrative Stress

Hepatology (Baltimore, Md.), 2021-06, Vol.73 (6), p.2180-2195

2021

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Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (2), p.536-541

2015

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Transgenic animal models in toxicology: historical perspectives and future outlook

Toxicological sciences, 2011-06, Vol.121 (2), p.207-233

2011

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Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity

Free radical biology & medicine, 2017-09, Vol.110, p.102-116

2017

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Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s

PloS one, 2014-02, Vol.9 (2), p.e87058-e87058

2014

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Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

PloS one, 2014-04, Vol.9 (4), p.e93261-e93261

2014

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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Glucosamine Enhances Paracetamol Bioavailability by Reducing Its Metabolism

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Computational simulations uncover enantioselective metabolism of chiral triazole fungicides by human CYP450 enzymes: A case study of tebuconazole

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes

Interaction between Changan Granule and its main components in the plasma and CYP450 enzymes

Four Different Structural Dietary Polyphenols, Especially Dihydromyricetin, Possess Superior Protective Effect on Ethanol-Induced ICE‑6 and AML-12 Cytotoxicity: The Role of CYP2E1 and Keap1-Nrf2 Pathways

Characterisation of cytochrome P450 isoenzyme activity in sheep liver and placental microsomes

Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

CYP2C19 Plays a Major Role in the Hepatic N -Oxidation of Cotinine

Absence of receptor interacting protein kinase 3 prevents ethanol‐induced liver injury

Mechanistic insights into the metabolic pathways of vanillin: unraveling cytochrome P450 interaction mechanisms and implications for food safety

Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis

Antibiotics-Induced Depletion of Rat Microbiota Induces Changes in the Expression of Host Drug-Processing Genes and Pharmacokinetic Behaviors of CYPs Probe Drugs

MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity

Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in‐vitro inhibition studies

Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration

Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress

Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol‐Inducible Cytochrome P450‐2E1–Mediated Oxidative and Nitrative Stress

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

Transgenic animal models in toxicology: historical perspectives and future outlook

Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity

Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s

Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

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