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The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

Annual review of biochemistry, 2016-06, Vol.85 (1), p.375-404

2016

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Nature chemical biology, 2011-05, Vol.7 (5), p.285-295

2011

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Targeting a neoantigen derived from a common TP53 mutation

Science (American Association for the Advancement of Science), 2021-03, Vol.371 (6533)

2021

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Why are there hotspot mutations in the TP53 gene in human cancers?

Cell death and differentiation, 2018-01, Vol.25 (1), p.154-160

2018

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MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

Cancer research (Chicago, Ill.), 2019-01, Vol.79 (1), p.251-262

2019

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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Nature (London), 2016-01, Vol.529 (7587), p.541-545

2016

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Mechanisms of transcriptional regulation by p53

Cell death and differentiation, 2018-01, Vol.25 (1), p.133-143

2018

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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Nature communications, 2021-02, Vol.12 (1), p.986-11, Article 986

2021

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Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

Nature (London), 2016-10, Vol.538 (7623), p.118-122

2016

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Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

Cell death and differentiation, 2017-02, Vol.24 (2), p.357-370

2017

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Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

Nature (London), 2017-05, Vol.545 (7653), p.229-233

2017

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Drugging the p53 pathway: understanding the route to clinical efficacy

Nature reviews. Drug discovery, 2014-03, Vol.13 (3), p.217-236

2014

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DAXX represents a new type of protein-folding enabler

Nature (London), 2021-09, Vol.597 (7874), p.132-137

2021

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53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

Molecular cell, 2016-10, Vol.64 (1), p.51-64

2016

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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Nature communications, 2021-06, Vol.12 (1), p.3962-24, Article 3962

2021

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PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins

Nucleic acids research, 2021-01, Vol.49 (D1), p.D404-D411

2021

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Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains

Scientific reports, 2020-01, Vol.10 (1), p.580-580, Article 580

2020

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TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

Human mutation, 2016-09, Vol.37 (9), p.865-876

2016

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Discoveries and controversies in BCL‐2 protein‐mediated apoptosis

The FEBS journal, 2016-07, Vol.283 (14), p.2690-2700

2016

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p53 β-hydroxybutyrylation attenuates p53 activity

Cell death & disease, 2019-03, Vol.10 (3), p.243, Article 243

2019

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The role of p53 in cancer drug resistance and targeted chemotherapy

Oncotarget, 2017-01, Vol.8 (5), p.8921-8946

2017

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p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept

International journal of molecular sciences, 2016-11, Vol.17 (11), p.1874-1874

Uversky, Vladimir N

2016

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Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (48), p.E11302-E11310

2018

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Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis

Cancer science, 2018-11, Vol.109 (11), p.3376-3382

2018

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Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

Nucleic acids research, 2014-07, Vol.42 (12), p.7666-7680

2014

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The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Targeting a neoantigen derived from a common TP53 mutation

Why are there hotspot mutations in the TP53 gene in human cancers?

MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Mechanisms of transcriptional regulation by p53

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

Drugging the p53 pathway: understanding the route to clinical efficacy

DAXX represents a new type of protein-folding enabler

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins

Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

Discoveries and controversies in BCL‐2 protein‐mediated apoptosis

p53 β-hydroxybutyrylation attenuates p53 activity

The role of p53 in cancer drug resistance and targeted chemotherapy

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept

Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

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