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High fat diet causes distinct aberrations in the testicular proteome

International Journal of Obesity, 2020-09, Vol.44 (9), p.1958-1969

2020

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Disruption of IRS-2 causes type 2 diabetes in mice

Nature (London), 1998-02, Vol.391 (6670), p.900-904

1998

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Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

Diabetologia, 2007-06, Vol.50 (6), p.1248-1256

2007

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Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

Nature genetics, 1999-09, Vol.23 (1), p.32-40

1999

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Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes

Endocrinology (Philadelphia), 2000-06, Vol.141 (6), p.1917-1921

2000

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Sex and Death: What Is the Connection?

Cell, 2005-02, Vol.120 (4), p.461-472

2005

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Insulin receptor substrate proteins and neuroendocrine function

Biochemical Society transactions, 2001-08, Vol.29 (Pt 4), p.525-529

Withers, D J

2001

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hypoxia response pathway and β-cell function

Diabetes, obesity & metabolism, 2010-10, Vol.12 (s2), p.159-167

2010

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5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus

Neuroscience, 2009-03, Vol.159 (1), p.83-93

2009

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Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice

The Journal of clinical investigation, 1997-12, Vol.100 (11), p.2729-2736

1997

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Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice

Diabetologia, 2006-03, Vol.49 (3), p.552-561

2006

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Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis

Molecular and Cellular Biology, 2002-01, Vol.22 (1), p.117-126

2002

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

Biochemical journal, 1999-12, Vol.344 (2), p.427-431

1999

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

Biochemical journal, 1998-08, Vol.333 ( Pt 3) (3), p.471-490

1998

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IRS-2 pathways integrate female reproduction and energy homeostasis

Nature (London), 2000-09, Vol.407 (6802), p.377-382

2000

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Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice

American journal of physiology: endocrinology and metabolism, 2012-09, Vol.303 (5), p.E659-E668

2012

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Signalling pathways involved in the mitogenic effects of cAMP

Clinical science (1979), 1997-05, Vol.92 (5), p.445-451

Withers, D J

1997

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Adrenomedullin: receptor and signal transduction

Biochemical Society transactions, 2002-08, Vol.30 (4), p.432-437

2002

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GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Nature (London), 2024-01, Vol.625 (7996), p.760-767

2024

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Regulation of anterior pituitary galanin and vasoactive intestinal peptide by oestrogen and prolactin status

Journal of endocrinology, 1997-02, Vol.152 (2), p.211-219

1997

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Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells

FEBS letters, 1996-01, Vol.378 (1), p.83-87

1996

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Longer Lifespan, Altered Metabolism, and Stress Resistance in Drosophila from Ablation of Cells Making Insulin-Like Ligands

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (8), p.3105-3110

2005

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Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Biochemical and biophysical research communications, 2009-08, Vol.386 (1), p.257-262

2009

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COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

Nature cell biology, 2023-12, Vol.25 (12), p.1804-1820

2023

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Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

Nature (London), 2006-05, Vol.441 (7091), p.366-370

2006

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High fat diet causes distinct aberrations in the testicular proteome

Disruption of IRS-2 causes type 2 diabetes in mice

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes

Sex and Death: What Is the Connection?

Insulin receptor substrate proteins and neuroendocrine function

hypoxia response pathway and β-cell function

5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice

Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

IRS-2 pathways integrate female reproduction and energy homeostasis

Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice

Signalling pathways involved in the mitogenic effects of cAMP

Adrenomedullin: receptor and signal transduction

GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Regulation of anterior pituitary galanin and vasoactive intestinal peptide by oestrogen and prolactin status

Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells

Longer Lifespan, Altered Metabolism, and Stress Resistance in Drosophila from Ablation of Cells Making Insulin-Like Ligands

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells

Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

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