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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Nature communications, 2020-10, Vol.11 (1), p.5370-5370, Article 5370

2020

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Potential function for the Huntingtin protein as a scaffold for selective autophagy

Proceedings of the National Academy of Sciences - PNAS, 2014-11, Vol.111 (47), p.16889-16894

2014

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Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

Neuron (Cambridge, Mass.), 2009-12, Vol.64 (6), p.828-840

2009

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Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

The Journal of neuroscience, 2008-11, Vol.28 (45), p.11500-11510

2008

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Human molecular genetics, 2008-12, Vol.17 (23), p.3767-3775

2008

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Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Nature communications, 2023-03, Vol.14 (1), p.1194-1194, Article 1194

2023

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Serine 421 regulates mutant huntingtin toxicity and clearance in mice

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3585-3597

2016

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A cause for childhood ataxia

eLife, 2016-03, Vol.5

Steffan, Joan S

2016

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APOE4 dysregulates autophagy in cultured cells

Autophagy reports, 2022-01, Vol.1 (1), p.29-33

2022

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Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.2041-2046

2003

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The Huntington's Disease Protein Interacts with p53 and CREB-Binding Protein and Represses Transcription

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (12), p.6763-6768

2000

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Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

Matrix biology plus, 2021-12, Vol.12, p.100089-100089, Article 100089

2021

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Normal-Repeat-Length Polyglutamine Peptides Accelerate Aggregation Nucleation and Cytotoxicity of Expanded Polyglutamine Proteins

Proceedings of the National Academy of Sciences - PNAS, 2006-09, Vol.103 (39), p.14367-14372

2006

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Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Experimental neurology, 2021-04, Vol.338, p.113463, Article 113463

2021

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Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

Journal of cell science, 2022-01, Vol.135 (2)

2022

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PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease

Proceedings of the National Academy of Sciences - PNAS, 2021-01, Vol.118 (4)

2021

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IKKβ slows Huntington’s disease progression in R6/1 mice

Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (22), p.10952-10961

2019

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Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Journal of Huntington's disease, 2022-01, Vol.11 (1), p.25

2022

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Autophagy researchers

Autophagy, 2014-02, Vol.10 (2), p.188-191

2014

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Histone Deacetylase Inhibitors Reduce Polyglutamine Toxicity

Proceedings of the National Academy of Sciences - PNAS, 2001-12, Vol.98 (26), p.15179-15184

2001

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Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

Stem cells translational medicine, 2017-06, Vol.6 (6), p.1477-1490

2017

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Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models

Journal of Huntington's disease, 2018-01, Vol.7 (2), p.137

2018

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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Nature genetics, 2002-04, Vol.30 (4), p.367-376

2002

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Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

Journal of Huntington's disease, 2018-01, Vol.7 (4), p.321

2018

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Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Potential function for the Huntingtin protein as a scaffold for selective autophagy

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

A cause for childhood ataxia

APOE4 dysregulates autophagy in cultured cells

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease

The Huntington's Disease Protein Interacts with p53 and CREB-Binding Protein and Represses Transcription

Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

Normal-Repeat-Length Polyglutamine Peptides Accelerate Aggregation Nucleation and Cytotoxicity of Expanded Polyglutamine Proteins

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease

IKKβ slows Huntington’s disease progression in R6/1 mice

Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Autophagy researchers

Histone Deacetylase Inhibitors Reduce Polyglutamine Toxicity

Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

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