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Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Autophagy, 2016-12, Vol.12 (12), p.2467-2483

2016

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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease

Cell reports (Cambridge), 2020-11, Vol.33 (8), p.108420-108420, Article 108420

2020

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Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Nature neuroscience, 2022-06, Vol.25 (6), p.688-701

2022

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mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Cell death & disease, 2019-07, Vol.10 (8), p.563-17, Article 563

2019

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Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function

Science advances, 2022-04, Vol.8 (17), p.eabj5716-eabj5716

2022

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BACE and γ-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

Neurochemical research, 2010-02, Vol.35 (2), p.181-210

2010

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Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders

Neurochemistry international, 2008-01, Vol.52 (1-2), p.184-215

2008

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Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function

Science advances, 2022-04, Vol.8 (17), p.eabj5716

2022

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Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: Consequences to morphology and viability on enzyme suppression in cultured primary neurons

Brain research, 2008-01, Vol.1191, p.136-147

2008

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Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells

Journal of molecular neuroscience, 2001-12, Vol.17 (3), p.351-360

2001

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Activation of caspase-3 and apoptosis in cerebellar granule cells

Journal of neuroscience research, 1998-05, Vol.52 (3), p.334-341

1998

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APP processing enzymes (secretases) as therapeutic targets: insights from the use of transgenics (Tgs) and transfected cells

Neurochemical research, 2003-07, Vol.28 (7), p.1049-1062

2003

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Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons

Neurochemical research, 1999-09, Vol.24 (9), p.1107-1115

1999

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Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte

Neuromolecular medicine, 2003-01, Vol.3 (2), p.95-104

2003

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BACE and g-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

Neurochemical research, 2010-02, Vol.35 (2), p.181-210

2010

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BACE and [gamma]-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

Neurochemical research, 2010-02, Vol.35 (2), p.181

2010

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Opposite effects of lithium on proximal and distal caspases of immature and mature primary neurons correlate with earlier paradoxical actions on viability

Neurochemical research, 2001-12, Vol.26 (12), p.1311-1320

2001

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Recent advances on neuronal caspases in development and neurodegeneration

Neurochemistry International, 1999-09, Vol.35 (3), p.195-220

1999

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APP processing enzymes (secretases) as therapeutic targets: Insights from the use of transgenics (Tgs) and transfected cells : Application of genetically altered mice models and their significance in neurodegenerative disease

Neurochemical research, 2003, Vol.28 (7), p.1049-1062

2003

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The Semisynthetic Glycosphingolipid LIGA20 Potently Protects Neurons Against Apoptosis

Annals of the New York Academy of Sciences, 1998-06, Vol.845 (1), p.253-262

1998

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The Semisynthetic Glycosphingolipid LIGA 20 Potently Protects Neurons Against Apoptosis

Annals of the New York Academy of Sciences, 1998-06, Vol.845 (1), p.253-262

1998

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Composition of white matter bovine brain coated vesicles: evidence that several components influence β-amyloid peptide to form oligomers and aggregates in vitro

Brain research, 1997-03, Vol.752 (1), p.72-80

1997

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Synthetic domains of cystatins linked to enkephalins are novel inhibitors of brain cathepsins L/B

Peptides (New York, N.Y. : 1980), 1990-07, Vol.11 (4), p.679-682

1990

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Met-enkephalin-Arg6-Phe7 metabolism: conversion to Met-enkephalin by brain and kidney dipeptidyl carboxypeptidases

Biochemical and biophysical research communications, 1981-03, Vol.99 (2), p.630-636

1981

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Metabolism of a heptateptide opioid by rat brain and cardiac tissue

Life sciences (1973), 1982-10, Vol.31 (16), p.1845-1848

1982

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Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function

BACE and γ-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function

Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: Consequences to morphology and viability on enzyme suppression in cultured primary neurons

Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells

Activation of caspase-3 and apoptosis in cerebellar granule cells

APP processing enzymes (secretases) as therapeutic targets: insights from the use of transgenics (Tgs) and transfected cells

Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons

Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte

BACE and g-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

BACE and [gamma]-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis

Opposite effects of lithium on proximal and distal caspases of immature and mature primary neurons correlate with earlier paradoxical actions on viability

Recent advances on neuronal caspases in development and neurodegeneration

APP processing enzymes (secretases) as therapeutic targets: Insights from the use of transgenics (Tgs) and transfected cells : Application of genetically altered mice models and their significance in neurodegenerative disease

The Semisynthetic Glycosphingolipid LIGA20 Potently Protects Neurons Against Apoptosis

The Semisynthetic Glycosphingolipid LIGA 20 Potently Protects Neurons Against Apoptosis

Composition of white matter bovine brain coated vesicles: evidence that several components influence β-amyloid peptide to form oligomers and aggregates in vitro

Synthetic domains of cystatins linked to enkephalins are novel inhibitors of brain cathepsins L/B

Met-enkephalin-Arg6-Phe7 metabolism: conversion to Met-enkephalin by brain and kidney dipeptidyl carboxypeptidases

Metabolism of a heptateptide opioid by rat brain and cardiac tissue

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