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Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

Neurobiology of disease, 2013-03, Vol.51, p.35-42

2013

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role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease

Journal of bioenergetics and biomembranes, 2009-12, Vol.41 (6), p.469-472

Hastings, Teresa G

2009

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LRRK2 activation in idiopathic Parkinson's disease

Science translational medicine, 2018-07, Vol.10 (451)

2018

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α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

Science translational medicine, 2016-06, Vol.8 (342), p.342ra78

2016

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LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

Neurobiology of disease, 2020-02, Vol.134, p.104626-104626, Article 104626

2020

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Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

Nature chemical biology, 2021-04, Vol.17 (4), p.465-476

2021

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NADPH oxidase 2 activity in Parkinson's disease

Neurobiology of disease, 2022-08, Vol.170, p.105754-105754, Article 105754

2022

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Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

Free radical biology & medicine, 2013-12, Vol.65, p.419-427

2013

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shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model

The Journal of clinical investigation, 2015-07, Vol.125 (7), p.2721-2735

2015

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Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone

Neurobiology of disease, 2016-07, Vol.91, p.247-261

2016

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Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells

Neurobiology of disease, 2009-06, Vol.34 (3), p.487-500

2009

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Parkinson's: Divergent Causes, Convergent Mechanisms

Science (American Association for the Advancement of Science), 2004-05, Vol.304 (5674), p.1120-1122

2004

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α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Redox biology, 2020-10, Vol.37, p.101695-101695, Article 101695

2020

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LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease

Science translational medicine, 2024-10, Vol.16 (767), p.eadl3438

2024

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Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity

Experimental neurology, 2004-05, Vol.187 (1), p.47-57

2004

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Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: Implications for Parkinson disease

Neurobiology of disease, 2008-03, Vol.29 (3), p.477-489

2008

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Potential Role of Mic60/Mitofilin in Parkinson's Disease

Frontiers in neuroscience, 2019-01, Vol.12, p.898-898

2019

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Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

NPJ Parkinson's Disease, 2023-08, Vol.9 (1), p.121-121, Article 121

2023

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Could a loss of α‐synuclein function put dopaminergic neurons at risk?

Journal of neurochemistry, 2004-06, Vol.89 (6), p.1318-1324

2004

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Leptin Protects against 6-Hydroxydopamine-induced Dopaminergic Cell Death via Mitogen-activated Protein Kinase Signaling

The Journal of biological chemistry, 2007-11, Vol.282 (47), p.34479-34491

2007

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Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson’s disease

NPJ Parkinson's Disease, 2020-11, Vol.6 (1), p.34, Article 34

2020

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Alpha‐synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells

Journal of neurochemistry, 2006-11, Vol.99 (4), p.1188-1196

2006

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Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine

Journal of neurochemistry, 2008-07, Vol.106 (1), p.333-346

2008

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comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation

Journal of neurochemistry, 2007-09, Vol.102 (6), p.2118-2131

2007

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Role of Oxidation in the Neurotoxic Effects of Intrastriatal Dopamine Injections

Proceedings of the National Academy of Sciences - PNAS, 1996-03, Vol.93 (5), p.1956-1961

1996

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Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson's disease

LRRK2 activation in idiopathic Parkinson's disease

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease

LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

NADPH oxidase 2 activity in Parkinson's disease

Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model

Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone

Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells

Parkinson's: Divergent Causes, Convergent Mechanisms

α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease

Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity

Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: Implications for Parkinson disease

Potential Role of Mic60/Mitofilin in Parkinson's Disease

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

Could a loss of α‐synuclein function put dopaminergic neurons at risk?

Leptin Protects against 6-Hydroxydopamine-induced Dopaminergic Cell Death via Mitogen-activated Protein Kinase Signaling

Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson’s disease

Alpha‐synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells

Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine

comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation

Role of Oxidation in the Neurotoxic Effects of Intrastriatal Dopamine Injections

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