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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PloS one, 2018-11, Vol.13 (11), p.e0206279-e0206279

2018

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Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

PloS one, 2012-04, Vol.7 (4), p.e34822

2012

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In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Drug metabolism and disposition, 2003-08, Vol.31 (8), p.1005-1015

2003

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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.243-253

2005

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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1616-1620

2014

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Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3555-3560

1998

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.625-634

2012

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Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

Journal of the American Chemical Society, 2000-03, Vol.122 (12), p.2677-2686

2000

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IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Drug metabolism and disposition, 2003-10, Vol.31 (10), p.1240-1250

2003

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Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7446-7457

2009

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On the Mechanism of Action of Cytochrome P450: Evaluation of Hydrogen Abstraction in Oxygen-Dependent Alcohol Oxidation

Biochemistry (Easton), 1994-05, Vol.33 (21), p.6442-6449

1994

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Discrete Species of Activated Oxygen Yield Different Cytochrome P450 Heme Adducts from Aldehydes

Biochemistry (Easton), 1999-08, Vol.38 (32), p.10511-10518

1999

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Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4644-4648

1996

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Journal of the American Chemical Society, 1991-07, Vol.113 (15), p.5886-5887

1991

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Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Biochemistry (Easton), 1995-04, Vol.34 (13), p.4246-4256

1995

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Aromatization of a Bicyclic Steroid Analog, 3-Oxodecalin-4-ene-10-carboxaldehyde, by Liver Microsomal Cytochrome P450 2B4

Biochemistry (Easton), 1994-11, Vol.33 (46), p.13651-13661

1994

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Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Journal of the American Chemical Society, 1998-09, Vol.120 (37), p.9718-9719

1998

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Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

Biochemistry (Easton), 1997-04, Vol.36 (16), p.4895-4902

1997

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1,2,3-Thiadiazole: A Novel Heterocyclic Heme Ligand for the Design of Cytochrome P450 Inhibitors

Biochemistry (Easton), 1997-06, Vol.36 (23), p.7209-7216

1997

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Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (9), p.3764-3768

1995

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Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

Biochemical pharmacology, 2001-06, Vol.61 (12), p.1463-1470

2001

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Significance of Glycine 478 in the Metabolism of N-Benzyl-1-aminobenzotriazole to Reactive Intermediates by Cytochrome P450 2B1

Biochemistry (Easton), 1997-09, Vol.36 (39), p.11707-11716

1997

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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

Chemico-biological interactions, 2005-06, Vol.155 (1), p.10-20

2005

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MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

Biochimica et biophysica acta, 2005-04, Vol.1707 (2), p.157-169

2005

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Cytochrome P450: progress and predictions

The FASEB journal, 1992-01, Vol.6 (2), p.669-673

1992

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

On the Mechanism of Action of Cytochrome P450: Evaluation of Hydrogen Abstraction in Oxygen-Dependent Alcohol Oxidation

Discrete Species of Activated Oxygen Yield Different Cytochrome P450 Heme Adducts from Aldehydes

Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Aromatization of a Bicyclic Steroid Analog, 3-Oxodecalin-4-ene-10-carboxaldehyde, by Liver Microsomal Cytochrome P450 2B4

Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

1,2,3-Thiadiazole: A Novel Heterocyclic Heme Ligand for the Design of Cytochrome P450 Inhibitors

Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

Significance of Glycine 478 in the Metabolism of N-Benzyl-1-aminobenzotriazole to Reactive Intermediates by Cytochrome P450 2B1

Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

Cytochrome P450: progress and predictions

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