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A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Science translational medicine, 2019-03, Vol.11 (485)

2019

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Light-controlled modulation of gene expression by chemical optoepigenetic probes

Nature chemical biology, 2016-05, Vol.12 (5), p.317-323

2016

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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia

Scientific reports, 2024-04, Vol.14 (1), p.9064-9064, Article 9064

2024

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TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

Molecular autism, 2020-01, Vol.11 (1), p.2-2, Article 2

2020

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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

Scientific reports, 2021-08, Vol.11 (1), p.17029-17029, Article 17029

2021

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Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Cell chemical biology, 2017-07, Vol.24 (7), p.892-906.e5

2017

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Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

Nature communications, 2017-11, Vol.8 (1), p.1659-17, Article 1659

2017

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In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.7999-8009

2014

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Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Journal of medicinal chemistry, 2019-11, Vol.62 (21), p.9600-9617

2019

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Monoalkoxy BODIPYsA Fluorophore Class for Bioimaging

Bioconjugate chemistry, 2014-06, Vol.25 (6), p.1043-1051

2014

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Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

Bioorganic & medicinal chemistry, 2016-09, Vol.24 (18), p.4008-4015

2016

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Dissecting structure–activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (4), p.1265-1271

2016

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Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Neuropharmacology, 2013-01, Vol.64, p.81-96

2013

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Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling

Translational psychiatry, 2018-07, Vol.8 (1), p.135-14, Article 135

2018

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An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration

Cells (Basel, Switzerland), 2019-11, Vol.8 (12), p.1531

2019

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Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

ACS medicinal chemistry letters, 2011-01, Vol.2 (1), p.39-42

2011

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An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Journal of the American Chemical Society, 2010-12, Vol.132 (47), p.16962-16976

2010

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Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis

Human molecular genetics, 2011-06, Vol.20 (12), p.2344-2355

2011

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The Fragile X Syndrome Protein FMRP Associates with BC1 RNA and Regulates the Translation of Specific mRNAs at Synapses

Cell, 2003-02, Vol.112 (3), p.317-327

2003

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Isolation of mouse neuritic mRNAs

Journal of Molecular Histology, 2006-01, Vol.37 (1-2), p.79-86

2006

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Prospects of TAT-mediated protein therapy for fragile X syndrome

Journal of molecular histology, 2004-05, Vol.35 (4), p.389-395

2004

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The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome

Human molecular genetics, 2003-05, Vol.12 (9), p.949-959

2003

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Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo

Human molecular genetics, 2004-07, Vol.13 (13), p.1291-1302

2004

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Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells

Experimental neurology, 2004-10, Vol.189 (2), p.343-353

2004

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Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin

ACS medicinal chemistry letters, 2010-10, Vol.2 (1), p.39-42

2010

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A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Light-controlled modulation of gene expression by chemical optoepigenetic probes

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Monoalkoxy BODIPYsA Fluorophore Class for Bioimaging

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

Dissecting structure–activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling

An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis

The Fragile X Syndrome Protein FMRP Associates with BC1 RNA and Regulates the Translation of Specific mRNAs at Synapses

Isolation of mouse neuritic mRNAs

Prospects of TAT-mediated protein therapy for fragile X syndrome

The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome

Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo

Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin

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