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Genetic architecture of human thinness compared to severe obesity

PLoS genetics, 2019-01, Vol.15 (1), p.e1007603-e1007603

2019

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TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

Nature genetics, 2009-03, Vol.41 (3), p.354-358

2009

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Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse

PLoS biology, 2014-09, Vol.12 (9), p.e1001952

2014

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Fat: an evolving issue

Disease models & mechanisms, 2012-09, Vol.5 (5), p.569-573

2012

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Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Molecular metabolism (Germany), 2017-10, Vol.6 (10), p.1321-1329

2017

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The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15

Scientific reports, 2024-01, Vol.14 (1), p.1899-1899, Article 1899

2024

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Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity

PLoS genetics, 2020-09, Vol.16 (9), p.e1008916-e1008916

2020

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Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function

PLoS biology, 2013-04, Vol.11 (4), p.e1001532

2013

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The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion

Scientific reports, 2017-12, Vol.7 (1), p.17593-12, Article 17593

2017

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Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis

PLoS biology, 2013-03, Vol.11 (3), p.e1001506-e1001506

2013

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Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

Molecular metabolism (Germany), 2017-05, Vol.6 (5), p.383-392

2017

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AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles

Molecular metabolism (Germany), 2017-04, Vol.6 (4), p.315-316

2017

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Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

PLoS genetics, 2013-01, Vol.9 (1), p.e1003166-e1003166

2013

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Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

PloS one, 2010-01, Vol.5 (1), p.e8771-e8771

2010

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Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

PLoS biology, 2011-01, Vol.9 (1), p.e1000575-e1000575

2011

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Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion

Scientific reports, 2019-10, Vol.9 (1), p.15574-20, Article 15574

2019

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Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion

Cell reports (Cambridge), 2021-03, Vol.34 (10), p.108810-108810, Article 108810

2021

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Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity

Disease models & mechanisms, 2011-11, Vol.4 (6), p.733-745

2011

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Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

Molecular metabolism (Germany), 2022-11, Vol.65, p.101589-101589, Article 101589

2022

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Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

Molecular metabolism (Germany), 2015-03, Vol.4 (3), p.199-209

2015

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Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure

Molecular metabolism (Germany), 2020-10, Vol.40, p.101020-101020, Article 101020

2020

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Influence of leptin on arterial distensibility: A novel link between obesity and cardiovascular disease?

Circulation (New York, N.Y.), 2002-10, Vol.106 (15), p.1919-1924

2002

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Leptin Predicts a Worsening of the Features of the Metabolic Syndrome Independently of Obesity

Obesity (Silver Spring, Md.), 2005-08, Vol.13 (8), p.1476-1484

2005

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Genetic architecture of human thinness compared to severe obesity

Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse

Fat: an evolving issue

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15

Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion

Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion

Phenotypic characterization of Adig null mice suggests roles for adipogenin in the regulation of fat mass accrual and leptin secretion

Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity

Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure

Influence of leptin on arterial distensibility: A novel link between obesity and cardiovascular disease?

Leptin Predicts a Worsening of the Features of the Metabolic Syndrome Independently of Obesity

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