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Advances in Antibody Design

Annual review of biomedical engineering, 2015-12, Vol.17 (1), p.191-216

2015

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Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility

Biochemical engineering journal, 2018-09, Vol.137, p.365-374

2018

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Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Nature communications, 2022-07, Vol.13 (1), p.3788-3788, Article 3788

2022

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Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods

mAbs, 2021-01, Vol.13 (1), p.1895540

2021

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Toward Drug-Like Multispecific Antibodies by Design

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7496

2020

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Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability

Scientific reports, 2017-03, Vol.7 (1), p.45259-45259, Article 45259

2017

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Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs

The Journal of biological chemistry, 2017-10, Vol.292 (40), p.16638-16652

2017

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Net charge of antibody complementarity-determining regions is a key predictor of specificity

Protein engineering, design and selection, 2018-11, Vol.31 (11), p.409-418

2018

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Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape

PLoS computational biology, 2022-05, Vol.18 (5), p.e1010160-e1010160

2022

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Structure-based design of conformation- and sequence-specific antibodies against amyloid β

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (1), p.84-89

2012

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An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Nature communications, 2019-11, Vol.10 (1), p.5031-11, Article 5031

2019

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Assessing developability early in the discovery process for novel biologics

mAbs, 2023, Vol.15 (1), p.2171248

2023

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Prion recognition elements govern nucleation, strain specificity and species barriers

Nature, 2007-05, Vol.447 (7144), p.556-561

2007

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Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions

Proteins, structure, function, and bioinformatics, 2011-09, Vol.79 (9), p.2637-2647

2011

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Engineered Autonomous Human Variable Domains

Current pharmaceutical design, 2016-01, Vol.22 (43), p.6527-6537

2016

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A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain

PloS one, 2021-10, Vol.16 (10), p.e0252558-e0252558

2021

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Unraveling infectious structures, strain variants and species barriers for the yeast prion [ PSI + ]

Nature structural & molecular biology, 2009-06, Vol.16 (6), p.598-605

2009

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Engineering Aggregation-Resistant Antibodies

Annual review of chemical and biomolecular engineering, 2012-07, Vol.3 (1), p.263-286

2012

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High-Throughput Analysis of Concentration-Dependent Antibody Self-Association

Biophysical journal, 2011-10, Vol.101 (7), p.1749-1757

2011

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Rational design of potent domain antibody inhibitors of amyloid fibril assembly

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (49), p.19965-19970

2012

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Highly sensitive detection of antibody nonspecific interactions using flow cytometry

mAbs, 2021-01, Vol.13 (1), p.1951426

2021

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Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

Scientific reports, 2021-10, Vol.11 (1), p.20738-20738, Article 20738

2021

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Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis

Frontiers in immunology, 2017-09, Vol.8, p.986-986

2017

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Reduction of monoclonal antibody viscosity using interpretable machine learning

mAbs, 2024, Vol.16 (1), p.2303781-2303781

2024

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Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

Frontiers in immunology, 2023-08, Vol.14, p.1164080-1164080

2023

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Advances in Antibody Design

Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods

Toward Drug-Like Multispecific Antibodies by Design

Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability

Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs

Net charge of antibody complementarity-determining regions is a key predictor of specificity

Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape

Structure-based design of conformation- and sequence-specific antibodies against amyloid β

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Assessing developability early in the discovery process for novel biologics

Prion recognition elements govern nucleation, strain specificity and species barriers

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions

Engineered Autonomous Human Variable Domains

A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain

Unraveling infectious structures, strain variants and species barriers for the yeast prion [ PSI + ]

Engineering Aggregation-Resistant Antibodies

High-Throughput Analysis of Concentration-Dependent Antibody Self-Association

Rational design of potent domain antibody inhibitors of amyloid fibril assembly

Highly sensitive detection of antibody nonspecific interactions using flow cytometry

Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening

Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis

Reduction of monoclonal antibody viscosity using interpretable machine learning

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

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