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Ni(II) Salts and 2-Propanol Effect Catalytic Reductive Coupling of Epoxides and Alkynes

Organic letters, 2011-08, Vol.13 (15), p.4140-4143

2011

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Erosion of Stereochemical Control with Increasing Nucleophilicity: O-Glycosylation at the Diffusion Limit

Journal of organic chemistry, 2010-02, Vol.75 (4), p.1107-1118

2010

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Desymmetrization of a Propane-1,3-diol to Introduce the Quaternary Chiral Center of an AMG 176 Drug Substance Intermediate

Synthesis (Stuttgart), 2023-08, Vol.55 (15), p.2397-2405

2023

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Stereoelectronic Model To Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates

Angewandte Chemie (International ed.), 2016-01, Vol.55 (5), p.1816-1819

International ed. in English, 2016

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Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead

Organic process research & development, 2020-04, Vol.24 (4), p.490-499

2020

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Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes

Organic process research & development, 2021-03, Vol.25 (3), p.486-499

2021

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Green Chemistry as a Driver for Innovation in the Pharmaceutical Industry

Israel journal of chemistry, 2021-07, Vol.61 (7-8), p.369-379

2021

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Continuous Process Improvement in the Manufacture of Carfilzomib, Part 1: Process Understanding and Improvements in the Commercial Route to Prepare the Epoxyketone Warhead

Organic process research & development, 2020-04, Vol.24 (4), p.481-489

2020

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Crystallization-Induced Dynamic Resolution of a Diarylmethylamine toward the Synthesis of a Potent TRPM8 Inhibitor

Organic process research & development, 2016-07, Vol.20 (7), p.1341-1346

2016

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Stereoelectronic Model To Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates

Angewandte Chemie, 2016-01, Vol.128 (5), p.1848-1851

2016

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Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition

Organic process research & development, 2020-10, Vol.24 (10), p.2139-2146

2020

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Building Complexity and Achieving Selectivity through Catalysis – Case Studies from the Pharmaceutical Pipeline

Synlett, 2021-03

2021

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A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation

Organic process research & development, 2020-10, Vol.24 (10), p.1861-1875

2020

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A Continuous Process for Manufacturing Apremilast. Part II: Process Characterization to Establish a Parametric Control Strategy

Organic process research & development, 2024-05, Vol.28 (5), p.1385-1401

2024

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A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration

Organic process research & development, 2020-10, Vol.24 (10), p.1891-1908

2020

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PAT-Enabled Automated Feedforward Control: An Application to the Continuous Manufacture of Apremilast

Organic process research & development, 2024-07, Vol.28 (7), p.2844-2853

2024

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A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process

Organic process research & development, 2020-10, Vol.24 (10), p.1876-1890

2020

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Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream

Organic process research & development, 2022-09, Vol.26 (9), p.2636-2645

2022

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Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation

Organic process research & development, 2024-04, Vol.28 (4), p.831-846

2024

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A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles

Organic process research & development, 2024-05, Vol.28 (5), p.1369-1384

2024

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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor

Organic process research & development, 2022-11, Vol.26 (11), p.3115-3125

2022

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Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS G12C Inhibitor

Organic process research & development, 2022-11, Vol.26 (11), p.3115-3125

2022

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Nucleophilic Substitution Reactions of 2-Phenylthio-Substituted Carbohydrate Acetals and Related Systems: Episulfonium Ions vs. Oxocarbenium Ions as Reactive Intermediates

European Journal of Organic Chemistry, 2008-02, Vol.2008 (5), p.771-781

2008

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ChemInform Abstract: Ni(II) Salts and 2-Propanol Effect Catalytic Reductive Coupling of Epoxides and Alkynes

ChemInform, 2011-12, Vol.42 (50), p.no-no

2011

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ChemInform Abstract: C-Glycosylation Reactions of Sulfur-Substituted Glycosyl Donors: Evidence Against the Role of Neighboring-Group Participation

ChemInform, 2008-06, Vol.39 (25), p.no-no

2008

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Ni(II) Salts and 2-Propanol Effect Catalytic Reductive Coupling of Epoxides and Alkynes

Erosion of Stereochemical Control with Increasing Nucleophilicity: O-Glycosylation at the Diffusion Limit

Desymmetrization of a Propane-1,3-diol to Introduce the Quaternary Chiral Center of an AMG 176 Drug Substance Intermediate

Stereoelectronic Model To Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates

Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead

Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes

Green Chemistry as a Driver for Innovation in the Pharmaceutical Industry

Continuous Process Improvement in the Manufacture of Carfilzomib, Part 1: Process Understanding and Improvements in the Commercial Route to Prepare the Epoxyketone Warhead

Crystallization-Induced Dynamic Resolution of a Diarylmethylamine toward the Synthesis of a Potent TRPM8 Inhibitor

Stereoelectronic Model To Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates

Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition

Building Complexity and Achieving Selectivity through Catalysis – Case Studies from the Pharmaceutical Pipeline

A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation

A Continuous Process for Manufacturing Apremilast. Part II: Process Characterization to Establish a Parametric Control Strategy

A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration

PAT-Enabled Automated Feedforward Control: An Application to the Continuous Manufacture of Apremilast

A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process

Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream

Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation

A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS G12C Inhibitor

Nucleophilic Substitution Reactions of 2-Phenylthio-Substituted Carbohydrate Acetals and Related Systems: Episulfonium Ions vs. Oxocarbenium Ions as Reactive Intermediates

ChemInform Abstract: Ni(II) Salts and 2-Propanol Effect Catalytic Reductive Coupling of Epoxides and Alkynes

ChemInform Abstract: C-Glycosylation Reactions of Sulfur-Substituted Glycosyl Donors: Evidence Against the Role of Neighboring-Group Participation

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