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Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application

Mini reviews in medicinal chemistry, 2023-01, Vol.23 (8), p.941-952

2023

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Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

Frontiers in neuroendocrinology, 2009-01, Vol.30 (1), p.65-91

2009

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Androgens and bone

Steroids, 2009-03, Vol.74 (3), p.296-305

2009

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The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α 1 β 3 γ 2L GABA A Receptor by Stabilizing a Novel Nonconducting State

Molecular pharmacology, 2022-02, Vol.101 (2), p.68-77

2022

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18β-Glycyrrhetinic acid synergizes with enzalutamide to counteract castration-resistant prostate cancer by inhibiting OATP2B1 uptake of dehydroepiandrosterone sulfate

European journal of pharmacology, 2024-11, Vol.983, p.176995, Article 176995

2024

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Partial Agonistic Actions of Sex Hormone Steroids on TRPM3 Function

International journal of molecular sciences, 2021-12, Vol.22 (24), p.13652

2021

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The effect of dehydroepiandrosterone sulfate and allopregnanolone sulfate on the binding of [ 3H]ifenprodil to the N-methyl- d-aspartate receptor in rat frontal cortex membrane

Journal of steroid biochemistry and molecular biology, 2005-02, Vol.94 (1), p.263-266

2005

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Dehydroepiandrosterone-sulfate is associated with cardiovascular reactivity to stress in women

Psychoneuroendocrinology, 2016-07, Vol.69, p.116-122

2016

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In vitro modulatory effect of dehydroepiandrosterone sulfate on apoptosis and expression of apoptosis‐related genes in patients with systemic lupus erythematosus

Journal of cellular physiology, 2019-08, Vol.234 (8), p.12676-12684

2019

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ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells

Cancer science, 2017-10, Vol.108 (10), p.2011-2021

2017

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Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor

Steroids, 2016-01, Vol.105, p.50-58

2016

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Insulin and Metformin Regulate Circulating and Adipose Tissue Chemerin

Diabetes (New York, N.Y.), 2009-09, Vol.58 (9), p.1971-1977

2009

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Dehydroepiandrosterone (DHEA), DHEA Sulfate, and Aging: Contribution of the DHEAge Study to a Sociobiomedical Issue

Proceedings of the National Academy of Sciences - PNAS, 2000-04, Vol.97 (8), p.4279-4284

2000

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Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus

Endocrinology (Philadelphia), 2015-07, Vol.156 (7), p.2704-2712

2015

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DHEAS prevents pro-metastatic and proliferative effects of 17ß-estradiol on MCF-7 breast cancer cells

Biochimica et biophysica acta. Molecular cell research, 2020-02, Vol.1867 (2), p.118600-118600, Article 118600

2020

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Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis

The European respiratory journal, 2013-11, Vol.42 (5), p.1309-1321

2013

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Effect of Dehydroepiandrosterone on Muscle Strength and Physical Function in Older Adults: A Systematic Review

Journal of the American Geriatrics Society (JAGS), 2011-06, Vol.59 (6), p.997-1002

2011

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Neurosteroid‐mediated regulation of brain innate immunity in HIV/AIDS: DHEA‐S suppresses neurovirulence

The FASEB journal, 2013-02, Vol.27 (2), p.725-737

2013

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Modulation of neurotransmitter systems by dehydroepiandrosterone and dehydroepiandrosterone sulfate: Mechanism of action and relevance to psychiatric disorders

Progress in neuro-psychopharmacology & biological psychiatry, 2008-07, Vol.32 (5), p.1118-1130

2008

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Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice

Behavioural brain research, 2011-08, Vol.221 (1), p.75-82

2011

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Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ25–35 peptide-induced toxicity in vitro and in vivo in mice

Psychopharmacology, 2014-09, Vol.231 (17), p.3293-3312

2014

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Organic Anion Transporter 4-Mediated Transport of Olmesartan at Basal Plasma Membrane of Human Placental Barrier

Journal of pharmaceutical sciences, 2015-09, Vol.104 (9), p.3128-3135

2015

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Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase

Molecular and cellular endocrinology, 2013-08, Vol.376 (1-2), p.148-155

2013

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Impairment of the Gnα11-controlled expression of claudin-1 and MMP-9 and collective migration of human breast cancer MCF-7 cells by DHEAS

The Journal of steroid biochemistry and molecular biology, 2018-09, Vol.182, p.50-61

2018

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Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors

British journal of pharmacology, 2009-06, Vol.157 (4), p.666-673

2009

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Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

Androgens and bone

The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α 1 β 3 γ 2L GABA A Receptor by Stabilizing a Novel Nonconducting State

18β-Glycyrrhetinic acid synergizes with enzalutamide to counteract castration-resistant prostate cancer by inhibiting OATP2B1 uptake of dehydroepiandrosterone sulfate

Partial Agonistic Actions of Sex Hormone Steroids on TRPM3 Function

The effect of dehydroepiandrosterone sulfate and allopregnanolone sulfate on the binding of [ 3H]ifenprodil to the N-methyl- d-aspartate receptor in rat frontal cortex membrane

Dehydroepiandrosterone-sulfate is associated with cardiovascular reactivity to stress in women

In vitro modulatory effect of dehydroepiandrosterone sulfate on apoptosis and expression of apoptosis‐related genes in patients with systemic lupus erythematosus

ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells

Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor

Insulin and Metformin Regulate Circulating and Adipose Tissue Chemerin

Dehydroepiandrosterone (DHEA), DHEA Sulfate, and Aging: Contribution of the DHEAge Study to a Sociobiomedical Issue

Role of OAT4 in Uptake of Estriol Precursor 16α-Hydroxydehydroepiandrosterone Sulfate Into Human Placental Syncytiotrophoblasts From Fetus

DHEAS prevents pro-metastatic and proliferative effects of 17ß-estradiol on MCF-7 breast cancer cells

Dehydroepiandrosterone has strong antifibrotic effects and is decreased in idiopathic pulmonary fibrosis

Effect of Dehydroepiandrosterone on Muscle Strength and Physical Function in Older Adults: A Systematic Review

Neurosteroid‐mediated regulation of brain innate immunity in HIV/AIDS: DHEA‐S suppresses neurovirulence

Modulation of neurotransmitter systems by dehydroepiandrosterone and dehydroepiandrosterone sulfate: Mechanism of action and relevance to psychiatric disorders

Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice

Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ25–35 peptide-induced toxicity in vitro and in vivo in mice

Organic Anion Transporter 4-Mediated Transport of Olmesartan at Basal Plasma Membrane of Human Placental Barrier

Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase

Impairment of the Gnα11-controlled expression of claudin-1 and MMP-9 and collective migration of human breast cancer MCF-7 cells by DHEAS

Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors

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