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Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV‑2 2′‑O‑Methyltransferase

Journal of natural products (Washington, D.C.), 2024-02, Vol.87 (2), p.217-227

2024

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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.229-235

2001

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Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

Antimicrobial Agents and Chemotherapy, 2000-12, Vol.44 (12), p.3465-3472

2000

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In Vitro Anti-HIV Activity of Biflavonoids Isolated from Rhus succedanea and Garcinia multiflora

Journal of natural products (Washington, D.C.), 1997-09, Vol.60 (9), p.884-888

1997

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Relationship between Antiviral Activity and Host Toxicity: Comparison of the Incorporation Efficiencies of 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine-Triphosphate Analogs by Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Human Mitochondrial DNA Polymerase

Antimicrobial Agents and Chemotherapy, 2004-04, Vol.48 (4), p.1300-1306

2004

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Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Antimicrobial agents and chemotherapy, 2016-08, Vol.60 (8), p.4659-4669

2016

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Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

Bioorganic & medicinal chemistry, 2005-07, Vol.13 (13), p.4168-4175

2005

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Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.158-165

2001

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Antiviral and Anticancer Optimization Studies of the DNA-binding Marine Natural Product Aaptamine

Chemical biology & drug design, 2008-03, Vol.71 (3), p.205-215

2008

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Randomized, Double-Blind, Multicenter Safety and Efficacy Study of Rifalazil Compared with Azithromycin for Treatment of Uncomplicated Genital Chlamydia trachomatis Infection in Women

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4014-4019

2014

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Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks

Antimicrobial Agents and Chemotherapy, 2000-06, Vol.44 (6), p.1757-1760

2000

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5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability : Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

Cancer chemotherapy and pharmacology, 2005-06, Vol.55 (6), p.541-551

2005

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Synthesis and anti-viral activity of a series of d- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system

Bioorganic & medicinal chemistry, 2005-03, Vol.13 (5), p.1641-1652

2005

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Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes

Antiviral research, 1997-03, Vol.34 (1), p.27-37

1997

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Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro

Antimicrobial Agents and Chemotherapy, 1994-09, Vol.38 (9), p.2172-2174

1994

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Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1994-2001

2005

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Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans

Antimicrobial Agents and Chemotherapy, 1998-11, Vol.42 (11), p.2804-2809

1998

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Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates

Antimicrobial Agents and Chemotherapy, 1995-05, Vol.39 (5), p.1087-1092

1995

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Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

Molecular pharmacology, 1991-02, Vol.39 (2), p.258-266

1991

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Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

Antiviral therapy, 2011-01, Vol.16 (7), p.1123-1130

2011

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Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

Antiviral research, 2002-07, Vol.55 (1), p.141-150

2002

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Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of d- and l-D4FC-TP

Antiviral research, 2004-04, Vol.62 (1), p.57-64

2004

Volltextzugriff (PDF)

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.853-858

2000

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The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Antimicrobial Agents and Chemotherapy, 1992-12, Vol.36 (12), p.2686-2692

1992

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Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV‑2 2′‑O‑Methyltransferase

Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

In Vitro Anti-HIV Activity of Biflavonoids Isolated from Rhus succedanea and Garcinia multiflora

Relationship between Antiviral Activity and Host Toxicity: Comparison of the Incorporation Efficiencies of 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine-Triphosphate Analogs by Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Human Mitochondrial DNA Polymerase

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

Antiviral and Anticancer Optimization Studies of the DNA-binding Marine Natural Product Aaptamine

Randomized, Double-Blind, Multicenter Safety and Efficacy Study of Rifalazil Compared with Azithromycin for Treatment of Uncomplicated Genital Chlamydia trachomatis Infection in Women

Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks

5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability : Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

Synthesis and anti-viral activity of a series of d- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system

Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes

Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro

Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans

Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates

Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of d- and l-D4FC-TP

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

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