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Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV‑2 2′‑O‑Methyltransferase

Journal of natural products (Washington, D.C.), 2024-02, Vol.87 (2), p.217-227

2024

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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.229-235

2001

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Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

Antimicrobial Agents and Chemotherapy, 2000-12, Vol.44 (12), p.3465-3472

2000

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Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Antimicrobial agents and chemotherapy, 2016-08, Vol.60 (8), p.4659-4669

2016

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Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

Bioorganic & medicinal chemistry, 2005-07, Vol.13 (13), p.4168-4175

2005

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Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.158-165

2001

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Randomized, Double-Blind, Multicenter Safety and Efficacy Study of Rifalazil Compared with Azithromycin for Treatment of Uncomplicated Genital Chlamydia trachomatis Infection in Women

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4014-4019

2014

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Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks

Antimicrobial Agents and Chemotherapy, 2000-06, Vol.44 (6), p.1757-1760

2000

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5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability : Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

Cancer chemotherapy and pharmacology, 2005-06, Vol.55 (6), p.541-551

2005

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Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1994-2001

2005

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Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans

Antimicrobial Agents and Chemotherapy, 1998-11, Vol.42 (11), p.2804-2809

1998

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Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

Molecular pharmacology, 1991-02, Vol.39 (2), p.258-266

1991

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Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

Antiviral therapy, 2011-01, Vol.16 (7), p.1123-1130

2011

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Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

Antiviral research, 2002-07, Vol.55 (1), p.141-150

2002

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Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of d- and l-D4FC-TP

Antiviral research, 2004-04, Vol.62 (1), p.57-64

2004

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Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.853-858

2000

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The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Antimicrobial Agents and Chemotherapy, 1992-12, Vol.36 (12), p.2686-2692

1992

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5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase

Biochemical pharmacology, 2000-09, Vol.60 (6), p.851-856

2000

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Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

Antimicrobial Agents and Chemotherapy, 1990-06, Vol.34 (6), p.1061-1067

1990

Volltextzugriff (PDF)

Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

Cancer chemotherapy and pharmacology, 2006-11, Vol.58 (5), p.692-698

2006

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Cell-Based and Animal Models for Hepatitis B and C Viruses

Antiviral chemistry & chemotherapy, 1999-05, Vol.10 (3), p.99-114

1999

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Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys

Antimicrobial Agents and Chemotherapy, 1999-04, Vol.43 (4), p.920-924

1999

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Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy

Cancer chemotherapy and pharmacology, 2001-08, Vol.48 (2), p.145-150

2001

Volltextzugriff (PDF)

Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26–10

Biochemical pharmacology, 2000-09, Vol.60 (5), p.687-692

2000

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Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Informatics and Computational Approaches for the Discovery and Optimization of Natural Product-Inspired Inhibitors of the SARS-CoV‑2 2′‑O‑Methyltransferase

Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

Randomized, Double-Blind, Multicenter Safety and Efficacy Study of Rifalazil Compared with Azithromycin for Treatment of Uncomplicated Genital Chlamydia trachomatis Infection in Women

Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks

5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability : Relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans

Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of d- and l-D4FC-TP

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase

Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

Cell-Based and Animal Models for Hepatitis B and C Viruses

Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys

Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy

Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26–10

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